Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 139 for “"Oligodendrocytes"”.
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Oligodendrocytes of the adult median eminence
Oligodendrocytes (OLs) are the myelin forming cells of the CNS. Once thought to be generated exclusively during development, recent advances have shown that new OLs are generated in the adult brain from oligodendrocyte progenitor cells (OPCs) in response to physiologically relevant stimuli such as …
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Oligodendrocytes of the adult hypothalamic median eminence
… precursor cells (OPCs) and mature myelinating oligodendrocytes (MOLs) are found in this region in adults. While proliferation of ME OPCs has been shown to be involved in bodyweight maintenance, not much is known about the functions of other subtypes of oligodendrocytes (OLs) in the region and …
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Cohesin Promotes the Myelination Transcriptional Program in Oligodendrocytes
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis
Selektiver Transfer von Exosomen von Oligodendrozyten zu Mikroglia durch Makropinozytose Oligodendrozyten sind die Myelin-bildenden Zellen des zentralen Nervensystems. Dieser Zelltyp bildet während der aktiven Phase der Myelinisierung große Mengen an Zellmembran aus. Zusätzlich werden …
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Role of the Neurotransmitter Glutamate in Neural Stem and Progenitor Cells Differentiation into Oligodendrocytes
… main cell types found within the brain: neurons, oligodendrocytes (OLs), and astrocytes. Adult NSPCs can be driven to specific cells of interest which can be used to replace lost myelin in some cases of neurodegenerative diseases such as multiple sclerosis (MS) or insults such as spinal cord …
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Stab Wounds to Rat Brains : Demyelination, Remyelination and the Cellular Response, Particularly of Oligodendrocytes
… is incomplete and controversial. The role of oligodendrocytes, the cells involved in phagocytosis, the stages of demyelination, and the evidence for remyelination are of interest. Following stab wounds to rat brain cortex, corpus callosum and hippocampus, the animals were examined at …
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Developing a selective sphingosine-1-phosphate-5 (s1p5) radiotracer to image oligodendrocytes using preclinical positron emission tomography (PET)
… sheathing around neurons, which are produced by oligodendrocytes) degenerate, leading to a loss of function, neuronal degeneration and disability. Although there have been advances in recent years, there is still no cure for MS or even a method to facilitate imaging oligodendrocytes activity in …
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Identification and Characterization of the Expression Profile of Oligodendrocyte-Derived and Associated Proteins via Unilateral X-Irradation of the Rat Optic Nerve
… profile of proteins derived from or regulated by oligodendrocytes can be elucidated. Specifically, we have demonstrated that oligodendrocytes can be selectively eliminated from one optic nerve of a rat by treating the animal with a unilateral exposure of X-irradiation at the time of birth. …
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Cytoarchitectural Defects Secondary To Experimentally Induced Oligodendrocyte Death In The Adult And Developing Central Nervous System
… the dynamic relationship between axons and oligodendrocytes has been the development of models in which oligodendrocytes can be experimentally eliminated from living tissues. However, confounding factors inherent in each of the existing models complicate data interpretation. Limitations …
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The oligodendrocyte lineage of the median eminence in the adaptation to diet-induced obesity
… degree of plasticity; Typically, populations of oligodendrocytes are long-lived, supporting their role in myelinating neuronal axons and providing trophic support to neurons. Meanwhile, oligodendrocyte progenitor cells (OPC) display continuous but modest proliferation, maintaining the OPC …
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Myelination diseases of the central nervous system: Artificial Axons as in vitro models of chemomechanical cues
… biological process wherein glial cells such as oligodendrocytes wrap myelin around neuronal axons, forming an insulative sheath that accelerates signal propagation down the axon. A major obstacle to understanding myelination is the challenge of visualizing and reproducibly quantifying this …
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Axon-glia interactions during central nervous system myelination
… resulting in a significant reduction of mature oligodendrocytes in the posterior region of mutants at the onset of myelination. Since the anterior spinal cord of mutants is indistinguishable from wildtype, these results demonstrate that reticulospinal axons provide a mitogenic and a survival …
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The Role of Neuronal Activity in Adult Myelin Plasticity
In the central nervous system, oligodendrocytes wrap membranes around axons to produce myelin. Their functional roles include rapid neurotransmission, synchronization, and functional maintenance. In the adult brain, 5% or more of the total cellular population consists of oligodendrocyte precursor …
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Autotaxin: A Regulator of Oligodendrocyte Differentiation
… to differentiate into fully mature, myelinating oligodendrocytes, they must be specified at the correct times and undergo coordinated changes in both gene expression and morphology. As oligodendrocytes differentiate, they transition from a bipolar morphology into a morphology characterized by a …
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The Role of Specific Integrase Strand Transfer Inhibitors (INSTIs) in the Alteration of Oligodendrocyte Maturation and Myelination in Hand
… to determine how the myelin sheath or the oligodendrocytes that synthesize the sheath are damaged. Thus, we hypothesized that the administration of ART contributed in part to the myelin loss in the CNS of HIV-positive patients. Previously, we have reported that the protease inhibitor class …
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An improved method for generating oligodendrocyte progenitor cells from murine induced pluripotent stem cells
… progenitor cell (OPC) gives rise to functional oligodendrocytes following transplantation into dysmyelinated regions of the central nervous system, and as such represents a candidate for potential therapeutic applications. It can be generated by directed differentiation of a variety of …
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The effects of increased Plp1 gene dosage on expression and processing of myelin proteins
… effects. These transient changes suggest the oligodendrocytes at low gene dosage retain the ability to regulate expression, production and incorporation of proteins into myelin thus maintaining the normal process of myelination. At high increased gene dosage (homozygous), oligodendrocytes in …
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Conductive PEDOT:PSS fibres for modelling and assessing oligodendrocyte ensheathment
Oligodendrocytes are recognised for their capacity to ensheath neuronal axons with tightly packed, multi-layered cell membranes, forming the myelin sheath. This myelin sheath plays a pivotal role as an insulating layer surrounding neuronal axons. It effectively segregates the conductive …
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