Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Oligodendrocyte progenitor cells"”.
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Stereological Analysis of Oligodendrocyte Progenitor Cells In the Adult Mouse Brain
… histological analysis of these closely apposed cells, corresponds to experiment 4.
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Functional heterogeneity of oligodendrocyte progenitor cells in the central nervous system
Oligodendrocytes are the myelinating cells of the central nervous system (CNS), whose function is to optimise neuronal transmission and preserving axonal integrity. Oligodendrocytes are derived from a stem cell population, called oligodendrocyte progenitor cells (OPCs). Oligodendrocyte lineage …
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An improved method for generating oligodendrocyte progenitor cells from murine induced pluripotent stem cells
… leukodystrophies, to traumatic CNS injury. The oligodendrocyte progenitor cell (OPC) gives rise to functional oligodendrocytes following transplantation into dysmyelinated regions of the central nervous system, and as such represents a candidate for potential therapeutic applications. It can be …
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Drug repurposing against the store-operated calcium entry (SOCE) pathway and subsequent exploration of SOCE in oligodendrocyte progenitor cells
… the proliferation of different lung cancer cells namely H520, H1752, and LK2. In agreement with previous studies with bona fide SOCE inhibitors, the chosen drugs significantly reduced proliferation of those lung cancer cells. Interestingly, the anti-proliferative activity of most of the …
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Rejuvenation of CNS Progenitors via Partial Reprogramming
Adult stem cells become less efficient at maintaining tissue integrity and repairing tissue damage with age. Oligodendrocyte progenitor cells (OPCs) are the largest population of stem cells in the adult CNS and give rise to oligodendrocytes. OPCs play a critical role in myelin regeneration …
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Establishment of the white matter stroke model in rats to study oligodendrogenesis
… transcription factors enhances proliferation of oligodendrocyte progenitor cells and promotes differentiation into mature oligodendrocytes in the injured spinal cord. The present study aims to test a hypothesis that the same approach would improve oligodendrogensis in the white matter stroke …
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Imaging Myelin Basic Protein expression in a model of remyelination by Magnetic Resonance Imaging using an Organic Anion Transporter Protein gene reporter system.
… by 1) pharmacologically targeting endogenous oligodendrocyte progenitor cells (OPCs) responsible for remyelination or 2) transplantation of myelinogenic cells (including OPCs). The first approach is appropriate for diseases with no defect in the myelinating cells, such as multiple sclerosis …
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The brain microenvironment and its role in oligodendrocyte progenitor cell ageing
… between the brain extracellular matrix (ECM), oligodendrocyte progenitor cells (OPCs) and astrocytes. During ageing the resident brain progenitors undergo cellular arrest causing a diminished regenerative response. Increasing research evidence supports the notion that the ageing brain ECM not …
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Exploring the methylome and transcriptome of young adult and aged OPCs
… adult mammals, including humans. The principal cells which participate in remyelination are the Oligodendrocyte Progenitor Cells (OPCs). Similar to other regenerative processes, remyelination efficiency declines with ageing. It is still unknown how much of this decline can be attributed to …
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Retinoid X Receptor activation reverses age-related deficiencies in myelin debris phagocytosis and CNS remyelination
… through the formation of myelin sheaths by oligodendrocytes, which are recruited as oligodendrocyte progenitor cells (OPCs) after demyelination in diseases such as Multiple Sclerosis (MS).A key environmental factor regulating OPC differentiation is the fate of myelin debris generated during …
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Regulation of oligodendrocyte lineage cell function by the RXR$\gamma$ nuclear receptor
… axons. Key players in this process are oligodendrocyte progenitor cells (OPCs), a widespread population of CNS progenitor cells which persist into adulthood. Remyelination is impaired in patients with chronic demyelinating conditions such as Multiple Sclerosis, and as with other …
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The Role of Transcription Factors in Regulating Adult Neurogenesis after Excitotoxic Brain Injury
… is well documented in many injury models, cells of the correct lineage for endogenous repair are not always regenerated. To understand why, the molecular profile of subventricular zone (SVZ)-derived neural progenitor cells (NPCs), and their response to injury was investigated. Expression of …
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The role of ATM responding to DNA damage induced by Xrcc1 deficiency during oligodendrocyte genesis
… characterized by differentiation defect of oligodendrocytes, also known as leukodystrophy. We found that neurons and astrocytes in the Xrcc1nes-cre; Atm-/- brain underwent normal differentiation and maturation in vivo and in vitro. But, fully mature oligodendrocyte markers, MBP, PLP and …
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Investigating neuroectodermal transdifferentiation: How do CNS progenitors form Schwann cells?
… central nervous system (CNS) are myelinated by oligodendrocytes. However, in response to demyelination, Schwann cells (SCs), the myelinating glia of the peripheral nervous system (PNS), can contribute to CNS remyelination. Although CNS-resident SCs were previously thought to have migrated into …
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Oligodendrocytes of the adult median eminence
Oligodendrocytes (OLs) are the myelin forming cells of the CNS. Once thought to be generated exclusively during development, recent advances have shown that new OLs are generated in the adult brain from oligodendrocyte progenitor cells (OPCs) in response to physiologically relevant stimuli such as …
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CNS Remyelination and the Gut Microbiota
… Our commensal microbes communicate with host cells at epithelial barriers, stimulate neural and endocrine axes and directly produce a plethora of long-range signalling molecules. Critically, the development and maintenance of the immune system depend on signals from the microbiota, and we know …
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