Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Oligodendrocyte precursor cells"”.
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Automated Identification and Tracking of Motile Oligodendrocyte Precursor Cells (OPCs) from Time-lapse 3D Microscopic Imaging Data of Cell Clusters in vivo
… and investigation into the migration of Oligodendrocyte precursor cells (OPCs) and its role in the central nervous system. However, current practice of image-based OPC motility analysis heavily relies on manual labeling and tracking on 2D max projection of the 3D data, which suffers from …
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Altering Inhibitory Extracellular Matrix Promotes Remyelination
… sheaths after injury, and is accomplished by oligodendrocyte precursor cells (OPCs) that proliferate, migrate, and differentiate into myelin-forming oligodendrocytes. A number of lesion-associated factors have been identified that interfere with the remyelination response. Chondroitin sulfate …
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Oligodendrocytes of the adult hypothalamic median eminence
… respond to nutrient availability. Both immature oligodendrocyte precursor cells (OPCs) and mature myelinating oligodendrocytes (MOLs) are found in this region in adults. While proliferation of ME OPCs has been shown to be involved in bodyweight maintenance, not much is known about the functions …
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Role of the Neurotransmitter Glutamate in Neural Stem and Progenitor Cells Differentiation into Oligodendrocytes
… of undifferentiated neural stem and progenitor cells (NSPCs) which persist from development, all throughout adulthood. These cells can differentiate into the three main cell types found within the brain: neurons, oligodendrocytes (OLs), and astrocytes. Adult NSPCs can be driven to specific cells …
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Developmental myelination and myelin plasticity during spatial working memory task acquisition
… neuronal impulses. Myelin sheaths are created by oligodendrocytes, which stem from oligodendrocyte precursor cells. During development neurons become myelinated, and this process can be modulated by environmental factors, ageing and various neurological disorders. The notion that myelin plays a …
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Oligodendrocyte precursor cell states and their regulation
Oligodendrocyte precursor cells (OPCs) differentiate into myelinating oligodendrocytes throughout life, allowing the formation of myelin during early development, but also following learning or demyelinating injuries. A number of factors are thought to regulate OPC proliferation and …
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Elucidating the role of bone morphogenetic protein-4 in regulating secondary injury mechanisms following traumatic spinal cord injury
… of BMP4 on spinal cord neural stem/progenitor cells (NPCs), oligodendrocyte precursor cells (OPCs), astrocytes and neurons. Here, for the first time, we demonstrate that BMP4 promotes cleaved caspase-3 expression in cultured neurons and oligodendrocytes and that acute BMP inhibition attenuates …
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Proneural Genes in Neocortical Development
… the formation of GABAergic interneurons and oligodendrocyte precursor cells (OPCs). However, little was understood about the regulatory controls that governed Neurog2 and Asc11’s proneural activities. During my PhD study, I first found that the proneural activity of Neurog2 declined at later …
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The Role of Neuronal Activity in Adult Myelin Plasticity
In the central nervous system, oligodendrocytes wrap membranes around axons to produce myelin. Their functional roles include rapid neurotransmission, synchronization, and functional maintenance. In the adult brain, 5% or more of the total cellular population consists of oligodendrocyte precursor …
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Mitochondrial metabolism and CNS myelination
… the onset of myelination, a process in which oligodendrocyte precursor cells (OPCs) differentiate and engage with axons to invest them with complex multilamellar sheaths. Myelin sheaths enable rapid saltatory signal propagation, synchronised signal conduction, and provide metabolic support to …
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The Role of Specific Integrase Strand Transfer Inhibitors (INSTIs) in the Alteration of Oligodendrocyte Maturation and Myelination in Hand
… to determine how the myelin sheath or the oligodendrocytes that synthesize the sheath are damaged. Thus, we hypothesized that the administration of ART contributed in part to the myelin loss in the CNS of HIV-positive patients. Previously, we have reported that the protease inhibitor class …
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Structural and functional heterogeneity of cells in the rat hippocampus
… and function of hippocampal neurons and glial cells. We found that 1) the excitability of CA1 pyramidal neurons exhibits a rhythm in resting membrane potential which is coupled to its near-24-h intrinsic redox oscillation, 2) the membrane potential of DG granule neurons displays oscillation …
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DEVELOPMENT OF NEW OLIGODENDROCYTE-BASED MODELS TO IDENTIFY PHARMACOLOGICAL AGENTS WITH REMYELINATING ACTIVITY
… date, drugs do not target the myelin-producing cells of the central nervous system: oligodendrocytes (OLs). To produce myelin and remyelinate, OLs must differentiate from oligodendrocyte precursor cells (OPCs) to their most mature form (mOLs). At intermediate stages, immature OLs (iOLs) …
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THE EFFECTS OF MYOCARDIAL INFARCTION ON NEUROINFLAMMATION: FOCUS ON THE ROLE OF EXTRACELLULAR VESICLES
… phase after MI. The activation of microglial cells in terms of inflammatory signaling pathways was significantly upregulated in the sub-chronic phase. Moreover, the chronic phase showed an elevation in the number of oligodendrocyte precursor cells (OPCs), as well as the maturation and …
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Elucidating the Principles of Brain Network Organisation through Neurosurgery
… analyses revealing that connector hubs, oligodendrocyte precursor cells (OPCs), and proto-oncogenes are uniquely enriched in the MD system making it vulnerable to oncogenesis. When investigating the cognitive impact of gliomas infiltrating the MD system, the data reveals long-term …
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LIPID COMPOSITION OF MICROGLIAL CELLS AND EFFECTS OF A REMYELINATION-PROMOTING ANTIBODY ON THE SPHINGOLIPID PATTERNS
… adults (Lemus et al., 2018). Myelin damage and oligodendrocyte death are caused by the autoimmune attack of T cells that cross the blood-brain barrier resulting in the formation of sclerotic plaques (Pearce, 2005, Lubetzki and Stankoff, 2014). In the early stages of the disease, damaged myelin …
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Impacts of developmental exposures to the harmful algal bloom toxin domoic acid on neural development and behavior
… I assessed DomA-induced alterations in cells required for the startle response. I found no differences in the number of sensory neuromasts or in the sensory cranial ganglia structures that detect the acoustic stimuli. However, the majority of DomA-treated larvae lacked one or both …