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Showing 1 to 5 of 5 for “"Oligoadenylate Synthetase 1"”.

  1. The Evolution of the Viral RNA Sensor OAS1 in Old World Monkeys and Cetartiodactyls

    Fish, IanThe Graduate School and University Center of The City University of New York2017

    … to detect and respond to viral infection. The oligoadenylate synthetase family of enzymes comprises a crucial part of this innate immune response, directly signaling endonuclease activity responsible for inhibiting viral replication. Oligoadenylate synthetase 1 plays a vital role in animal …

    cuny-grad Repository record

  2. Prenylation in cell-intrinsic innate immunity to positive-strand RNA viruses

    Soveg, Frank William2021

    … zinc finger antiviral protein (ZAP) and oligoadenylate synthetase 1 (OAS1). The long isoform of ZAP, ZAP-L, is prenylated and targeted to endosomes and lysosomes. This localization is critical for its antiviral activity against alphaviruses, which use those compartments for RNA …

    washington Repository record

  3. Cancer Cell Antiviral Signaling Amplifies Transcription Output Through Chromatin Alterations To Drive Therapy Resistance

    Melidosian, Bihui2020

    … an RNA pattern recognition receptor (PRR), 2’-5’-oligoadenylate synthetase 1 (OAS1). OAS1 amplifies the IFN-I pathway in cancer cells, which increases multiple immune inhibitory genes. Accordingly, abrogating IFN-I signaling in cancer cells restores IFN signaling in immune populations and broadly …

    penn Repository record

  4. The Role of Interferon Stimlated Genes in Resistance and Immunity to Hepatitis C Virus Infection

    Erickson, Andrea Kaup2010

    … biological relevance of a genetic variant of the oligoadenylate synthetase 1 (OAS1) gene in resistance to HCV infection, an integrated approach of epidemiology, molecular genetics, and functional biology was used. Genetic and epidemiologic analyses identified a single-base mutation in OAS1 that …

    utswmed Repository record

  5. Effects of mannan oligosaccharide on immune function and disease resistance in pigs

    Che, Tung M.University of Illinois at Urbana-Champaign2010

    … complement system-associated molecules and 2’,5’-oligoadenylate synthetase-1. The downregulation of inflammatory responses regulated by MOS at d 7 PI was associated with several important canonical pathways such as triggering receptor expressed on myeloid cells-1 signaling, hypoxia signaling, IL-4 …

    uiuc Repository record