Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Olig2"”.
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Regulation of Oligodendrogenesis in a Rat Contusive Spinal Cord Injury
… recombinant retroviruses encoding Olig1 or Olig2 with enhanced green fluorescent proteins (eGFPs) were directly injected into the injured rat spinal cord immediately after contusive injury. Surprisingly, introduction of Olig2 led to a marked hyperplasia of GFP+ cells at 1 week after SCI. …
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Expression Analysis and Stem Cell Engineering
… Unexpectedly, neural genes: Sox1, Olig1, and Olig2 were unmethylated in non-neural cells and tissues. The correlation between methylation and silencing was not universal; it was gene specific. In the third study, ES cells were genetically engineered to permit drug selection of subset of ES …
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Establishment of the white matter stroke model in rats to study oligodendrogenesis
… showed that overexpression of both Olig1 and Olig2 transcription factors enhances proliferation of oligodendrocyte progenitor cells and promotes differentiation into mature oligodendrocytes in the injured spinal cord. The present study aims to test a hypothesis that the same approach would …
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The Dual Role of Notch Signaling During Motor Neuron Differentiation
Throughout the developing spinal cord, Olig2+ progenitors in the motor neuron progenitor domain give rise to an impressive array of motor neurons, oligodendrocytes and astrocytes. Motor neurons are further diversified into motor columns and pools based on cell body settling position, general axonal …
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The Role of Transcription Factors in Regulating Adult Neurogenesis after Excitotoxic Brain Injury
… the transcription factors Mash1, Dlx2, Pax6 and Olig2 in transitamplifying- precursor cells (TAPs) and neuroblasts was examined following quinolinic acid (QA) lesioning of the adult rat striatum. It was demonstrated that TAPs responded to lesioning in a heterogeneous manner, with expansion …
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Implicaciones pronósticas de la relación subventricular en el gliobastoma multiforme: caracterización clínica, radiológica y patológica
… análisis de la inmunoexpresión de los marcadores Olig2, PGFA, EGFR, p53, MGMT, NFP, IDH1 e YKL-40 sobre una muestra de 204 pacientes, estratificados por grupos ( I, II, III, IV y V) en función de la relación subventricular, los cuales a su vez se subdividieron en profundos (I, II, V) y …
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Investigating neuroectodermal transdifferentiation: How do CNS progenitors form Schwann cells?
… external pathways can directly interact with Olig2 and Sox10, which are critical regulators of cell fate in oligodendroglial cells and SCs. I then showed that OPCs can be directly reprogrammed toward a SC fate by manipulating the expression levels of Olig2 and Sox10. To further characterise …
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Low Reactive Oxygen Species and High Glycolysis In Glioblastoma Stem Cells:Mechanisms and Therapeutic Implications
… down-regulation of molecules including SOX2, and Olig2, and Notch1 that are important for stem cell function and an upregulation of mitochondrial superoxide dismutase SOD2 that converts O<sub>2</sub><sup>-</sup> to H<sub>2</sub>O<sub>2</sub>. Neutralization of ROS by antioxidant N-acetyl-cysteine …
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Recording Transcription Factor Binding During Development
… early binding events of the transcription factor Olig2 during neural differentiation. In summary, this dissertation presents a useful method for recording transcription factor binding during development.</p>
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Effects of the OTX2ECR2 enhancer & PROX1 overexpression in murine retina development
… studies of retinal progenitor cells that are OLIG2+ that give rise to both rod photoreceptors and amacrine cells, we decided to test if these same cells would have a history of <em>OTX2ECR2</em>. In this study we report that OLIG2+ retinal progenitor cells showing activity of the <em>OTX2ECR2 …
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CNS Neural/Glial Progenitors as Targets of HIV-1 and Opiates: Effects on Proliferation and Population Dynamics May Alter Behavior Outcomes.
… the proliferation and population of Sox2+ and Olig2+ cells in the absence of cell death. The interactive effects of morphine and either Tat or supernatant from HIV-1SF162 infected monocytes varied depending on outcome measure and time of exposure, but interactive effects occurred primarily on …
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The effect of aging on myelinating gene expression and oligodendrocyte cell densities
… decrease in the number of OL lineage cells (Olig2Nuc+ve/GFAP-ve cells) in the RCC of both control mice and mice recovering from cuprizone-induced demyelination. My results also show there was an age-related impaired recruitment of progenitor cells to replace lost OLs even though there was no …
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The Role of Glutamine and Mevalonate Pathway In Affecting The Stemness and Viability of Glioblastoma Stem Cells
… patients and expressed stem cell markers CD133, Olig2 and SOX2, to explore their bioenergetics by monitoring the oxygen consumption as an indication of mitochondrial respiration cultured in serum-free medium in comparison with that incubated in medium containing FBS. We found that GSC11 and GSC23 …
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Removal of Pax6 from cortical progenitors renders them abnormally likely to switch fate in response to Sonic Hedgehog activity
… showed significant increases of Gsx2+, Dlx1+ Olig2+ cells in parallel with the increase of Shh agonist concentrations. We also investigated the possibility that these cells matured into interneurons (INs) after exposure to SAG, if they do have electrical properties akin to specific type of …
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A multi-dimensional microfluidic platform recapitulating chemotactic and morphogenic chemical gradients
… neural tube transcription factors (Nkx2.2, Olig2, and Pax6) - is inhibition of Nkx2.2 expression and p3 progenitor domain specification. On the basis of our new model, we postulate that the two opposing influences of Wnt on Sonic hedgehog signaling have distinct but dependent functions: …
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Quantifizierung und zelluläre Lokalisation von Eisen in der Substantia nigra bei Patienten mit Parkinsonscher Erkrankung und gesunden Kontrollen
… Marker (anti-HuC/D, -IBA-1, -GFAP, -CNPase, -OLig2, -MBP, -Ferritin, -HLA) nach Standardprotokoll mit einer Ni-DAB Verstärkung. Histochemische Färbungen nach Perls und Turnbull wurden zum semiquantitativen Eisennachweis durchgeführt. Als Methode zur ortsaufgelösten quantitativen …
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Molecular and cellular regulation of motoneuron differentiation of human neural stem cells
… developmental transcription factors including Olig2, Ngn2, Islet1 and Hb9.\r\nvi.\r\nWe also found that the motoneuron determinant, Hb9, was induced in hNSCs in bFGF-dose and time-dependent manner and that blockade of bFGF signaling reduced Hb9 expression. Furthermore, bFGF treatment did not …
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Merlin Regulation of Mouse Spinal Cord Neural Precursor Cell Function
… was observed, Nf2 gene inactivation in GFAP or Olig2 transgene-positive cells did not lead to increased gliogenesis or tumor formation. These observations suggest that other temporal and or cooperative genetic events are necessary for SC ependymoma development.</p>
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Investigating the expression of plasma membrane calcium ATPase (PMCA) in patient-derived glioblastoma cultures
… cultures using markers such as CD44 and Olig2 confirmed the coexistence of mesenchymal and proneural features within individual patient-derived cultures, reinforcing the intratumoral heterogeneity observed in clinical glioblastoma. The results of this study provide evidence that PMCA …
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Molecular Interplay of Chromatin Remodeling Factor BRG1 and Transcription Factor STAT3 Regulates Stemness, Chemosensitivity and Tumorigenicity of Glioma Tumor Initiating Cells
… and S100, as well as the oligodendroglial marker Olig2. These findings indicate that BRG1 loss in GICs resulted in a transition towards a more differentiated fate. Targeted microarrays identified several genes that are dependent on BRG1 in GICs. One of these genes is TXNIP, a major redox regulator …
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