Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Olig1"”.
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Regulation of Oligodendrogenesis in a Rat Contusive Spinal Cord Injury
… cells, recombinant retroviruses encoding Olig1 or Olig2 with enhanced green fluorescent proteins (eGFPs) were directly injected into the injured rat spinal cord immediately after contusive injury. Surprisingly, introduction of Olig2 led to a marked hyperplasia of GFP+ cells at 1 week after …
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Establishment of the white matter stroke model in rats to study oligodendrogenesis
… We previously showed that overexpression of both Olig1 and Olig2 transcription factors enhances proliferation of oligodendrocyte progenitor cells and promotes differentiation into mature oligodendrocytes in the injured spinal cord. The present study aims to test a hypothesis that the same approach …
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Expression Analysis and Stem Cell Engineering
… and tissues. Unexpectedly, neural genes: Sox1, Olig1, and Olig2 were unmethylated in non-neural cells and tissues. The correlation between methylation and silencing was not universal; it was gene specific. In the third study, ES cells were genetically engineered to permit drug selection of …
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The role of ATM responding to DNA damage induced by Xrcc1 deficiency during oligodendrocyte genesis
… of the oligodendrocyte transcription factor, Olig1. Taken together, our data demonstrate Atm is critical for the proper development of cerebellum and neural cell differentiation, especially oligodendrocytes.
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Autotaxin: A Regulator of Oligodendrocyte Differentiation
… early and later stages of development such as olig1 and myelin basic protein (mbp), respectively. Data from our laboratory demonstrate that autotaxin (ATX), also referred to as phosphodiesterase Iα/autotaxin (PD-Iα/ATX), is involved in all of these processes as a multifunctional protein by …
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Conditional Multifactorial Contingency (CMC) Model and Its Applications
… truth, in addition to the previously known TFs, Olig1 (ranks 2nd), Olig2 (ranks 3rd), and Sox10 (ranks 4th), we successfully identified Ppp1r14b (ranks 1st) and Zfp36l1 (ranks 6th) that function in oligodendrocyte lineage development, which was validated via biological knock-out experiments and, …