Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Olfactory ensheathing cells"”.
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Migration of olfactory ensheathing cells grafted into adult rat spinal cord
Olfactory ensheathing cells (OECs) are non-myelinating glial cells that provide ensheathment for axons of the olfactory nerve in vivo. OECs have been shown to facilitate the regeneration of CNS axons, to assemble a myelin sheath around demyelinated axons, and it has been suggested OECs migrate very …
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A Comparative Analysis of the Neurochemical Properties of Olfactory Ensheathing Cells and their Biocompatibility in Various Biomatrices
Olfactory ensheathing cells (OECs) are the chief glial population of the mammalian olfactory nervous system and are thought to be responsible for the successful directional growth of new olfactory axons throughout the life of adult mammals. Due to this unique property, OECs have been targeted as a …
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The role of complex gangliosides in glial cell biology
… as well as the regeneration of the olfactory system and myelination were studied using mice lacking enzymes involved in ganglioside biosynthesis. Regeneration of the olfactory system in ganglioside knockout mice was similar to that of wild-type mice. However, proliferation of …
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A toxicological analysis of the cyanotoxin β-methylamino-L-alanine at multiple neural levels and identification of novel modes of activity
… presumably via activation of NMDA receptors. Rat olfactory ensheathing cells (OECs) were also challenged with exogenous BMAA resulting in elevated cell death. Significant increases in Ca2+ influx, enhanced production of ROS, and disruption to mitochondrial activity were observed in OECs. This is …
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Olfactory ensheathing cell mediated mechanisms of neurite outgrowth and axon regeneration
The capacity of the olfactory neuraxis to undergo neuronal replacement and axon targeting following injury, has led to scrutiny concerning the molecular and physical determinants of this growth capacity. This is because injury to the central nervous system, in contrast, leads to permanent …
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Identification, regulation and lineage tracing of embryonic olfactory progenitors
… zone and dentate gyrus in the brain, and olfactory epithelium (OE) in the periphery. Cell replacement after death or injury, occurs to varying degrees in neural tissue, and is thought to be dependent upon the biological responses of stem and/or progenitor cells. Despite the progress made …
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Directly induced Neural Stem Cells transplantation and prospects for stem cell-based therapy
… and (iii) replace the damaged myelin in PMS. Olfactory Ensheathing Cells (OECs) are a special population of glial cells known to exert neuroprotective mechanisms and capable of promoting neuroprotection. Using in vitro models of neuron-like cells, I have demonstrated that OECs exert their …
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Olfactory Ensheathing Cell Development: A Transcriptome Profiling Approach
Olfactory ensheathing cells (OECs), the glia of the olfactory nerve, are promising candidates for patient-specific cell-mediated repair of both peripheral nerves and the spinal cord. The recent discovery that OECs originate from the neural crest, rather than the olfactory epithelium as previously …
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The glial cell line-derived neurotrophic factor family in the olfactory system and brain
… Two regions of the brain were studied -- the olfactory system, a unique region of the nervous system that supports lifelong neurogenesis; and the substantia nigra (SN), the site of DA neuron degeneration in PD. Expression of GDNF, NTN, GFRα1 and GFRα2 was previously characterized in the …
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Contribution of microglial reactivity to olfactory ensheathing cell migration in vivo
Olfactory ensheathing cells (OECs) are glial cells that are an attractive candidate for neural repair after spinal cord injury and for remyelination of axons in diseases such as multiple sclerosis. OECs appear to migrate within the adult mammalian central nervous system (CNS) in animal models of …
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Grelina e cellule olfattive: effetti sulla modulazione del food-intake, come supporto trofico e suo possibile ruolo nel differenziamento.
La grelina (Ghre), ormone peptidico responsabile della comunicazione tra intestino e cervello, ed il suo recettore (GHS-R 1a) sono espressi in diverse parti dell’organismo, come ad esempio a livello dei bulbi olfattivi (OB). Nel sistema nervoso centrale, Ghre è stata osservata principalmente nei …
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Promoting bridging axonal regeneration after spinal cord injury
Olfactory ensheathing cells (OECs) are amongst the best candidates for cell transplantation into lesions of the central nervous system. These specialised glial cells are found in the olfactory system and are associated with the physiological restoration of neuronal circuitry in the first cranial …