Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Oleanolic acid"”.
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Oleanolic Acid Improves Different Aspects of Wound Healing
Entre los compuestos naturales bioactivos, los triterpenoides pentacíclicos son conocidos por sus efectos farmacológicos y gran versatilidad, entre los cuales, el ácido oleanólico (AO), es conocido por sus propiedades antitumorales, antiinflamatorias, antioxidantes o hepatoprotectoras. La …
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Ursolic acid and oleanolic acid as novel therapeutic agents in breast cancer
… treatment. The effects of non-toxic triterpenes, oleanolic acid and ursolic acid and the role of autophagy and apoptosis as mechanisms to overcome drug resistance in breast cancer were studied in vitro in MCF-7 breast cancer cells and MCF10A breast cells. In this study the first aim was to …
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Design, synthesis, and biological evaluation of Antimycobacterial agents from plant derived Betulinic acid, Oleanolic acid and their derivatives
… develop potent hit/drug leads for TB, betulinic acid (BA) and oleanolic acid (OA) were isolated respectively from Curtisia dentata and Syzigum aromaticum. The 3-O- acetyl analogue of BA and OA were synthesized. The cinnamic acid conjugates at C-28 position of the four (4) synthesized compounds …
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Antimycobacterial, docking and molecular dynamic studies of pentacyclic triterpenes from Buddleja saligna leaves
… Africa. Two isomeric pentacyclic triterpenes, oleanolic acid and ursolic acid, were isolated from the leaves of B. saligna using silica gel column chromatography. Compounds oleanolic acid and ursolic acid were subjected to derivatization with acetic anhydride in the presence of pyridine to …
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Pharmacognostic study of 5 medicinal plant species from Western Cape Province (South Africa) for anti-tubercular activity
… of pentacyclic triterpenoids, ursolic acid (UA) and oleanolic acid as major antitubercular constituents of B. saligna, L. gnaphaloides, and 1. graveolens. The in vitro cytotoxicity assays of the isolated bioactive constituents showed no cytotoxicity against Chinese Hamster Ovarian (CHO) …
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Anti-platelet aggregation activity of melaleuca bracteata var.revolution gold derived betulinic acid and its derivatives
… cardiovascular diseases. In this study, betulic acid (BA) and a mixture of betulinic acid and oleanolic acid (BA/OA) isolated from Melaleuca bracteata leaf extract and their acetyl derivatives (3-β acetylbetulinic acid) (BAA), (3-β acetylbetulinic acid and 3-β acetyloleanolic acid mixture) …
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Protecting Healthy Cells Against the Negative Effects of Radiation Therapy for Lung Cancer
Although radiation therapy is a commonly used treatment for many human diseases including cancer, ionizing radiation produces reactive oxygen species that can damage both cancer and healthy cells. Synthetic triterpenoids, including CDDO-Me, act as anti-inflammatory, antioxidant modulators primarily …
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ASSESSMENT OF CELL AND METABOLIC IMPACT OF MICROTUBULE TARGETING AGENTS (MTA) IN NEURODEGENERATION AND NEURON MODELS.
… we observe an overall reduction in amino acids consumption upon differentiation, probably due to the increased mitochondrial fission, which may fit the assumption that energy requirements for differentiated cells are reduced compared to growing cells, being mostly post-mitotic and blocked …
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Anti-inflammatory and anti-colon cancer potential of yerba mate (Ilex paraguariensis St. Hilaire) bioactive constituents
… extract, decaffeinated MT extract, chlorogenic acid (CHA), caffeine from MT (matein), mate saponins, quercetin, ursolic and oleanolic acids were tested by measuring their ability to inhibit COX-2/PGE2 and iNOS/NO pathways. Quercetin was the most potent inhibitor of pro-inflammatory responses at …