Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Olanzapine"”.
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Mechanism of Action of Antipsychotics, Haloperidol and Olanzapine in vitro
… resulting in movement disorders in patients. Olanzapine, a new atypical neuroleptic, seems to have better efficacy, with less severe adverse effects. There has been increasing evidence of the role of reactive oxygen species (ROS) and oxidative stress in the pathogenesis of Schizophrenia. We …
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Chronic Olanzapine Treatment Eliminates Cognitive Deficits Produced by Neonatal Quinpirole Treatment.
<p>This study evaluated the effects of chronic olanzapine treatment on cognitive performance and neurochemical function in a rodent model of schizophrenia. Animals were neonatally treated with quinpirole, a dopamine D<sub>2</sub> receptor agonist, or saline. Quinpirole treatment produces an …
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An Investigation of Sleep Architecture and Consequent Cognitive Changes in Olanzapine Treated Patients with Depression
Objective: Primarily, to determine the effect of olanzapine augmentation therapy on sleep architecture, specifically slow wave sleep (SWS), in the treatment of depression. Secondarily, to determine the effect of olanzapine augmentation therapy on illness severity and cognitive function. Finally, to …
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Estudo comparativo entre antipsicóticos atípicos no tratamento da esquizofrenia e sua influência na qualidade de vida dos pacientes
… the influence of atypical antipsychotics, olanzapine and risperidone on the quality of life and on their adverse effects in schizophrenic patients. For this we analyzed the quality of life of patients with implementation of EuroQol-5D-3L instrument and performing biochemical and hormonal …
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Antipsychotic drugs for the treatment of acute schizophrenia after the first episode
… weight gain (p=0.003) and akathisia (p=0.005); olanzapine and quetiapine for weight gain (p<0.001), risperidone and quetiapine for increased duration of sleep (p=0.02), olanzapine and risperidone for weight gain (p=0.03), olanzapine and haloperidol for weight gain (p<0.001) and akathisia …
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Multiple Memory Systems in People With Schizophrenia: Possible Effect of Atypical Anti-Psychotic Medications
… that patients with schizophrenia treated with olanzapine would have a poorer performance on the IGT, but not the PCL, when compared with controls. This study aimed to clarify conflicting results from prior experiments observing the effects of olanzapine on implicit memory in people with …
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Prediction of In-Vivo Antimuscarinic Activity (AMA) by In-Vitro Receptor Binding Assessment and PK/PD Modeling For Prototypical Drugs
… receptors, was performed. Prototypical drugs olanzapine, diphenhydramine, paroxetine were selected for the analysis. Scopolamine and darifenacin were included as positive and negative controls, respectively. Physiochemical properties, pharmacokinetic data, and clinical incidence of AMAEs for …
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STRATEGIES TO TARGET HUMAN D-ASPARTATE OXIDASE AND MODULATE ENDOGENOUS D-ASPARTATE LEVELS IN SCHIZOPHRENIA
… of D-Asp. 5-aminonicotinic acid (5-ANA) and olanzapine are mild inhibitors of human DASPO (hDASPO), thus new potential inhibitors were synthetised starting from the latter and their efficacy was tested in the Amplex UltraRed inhibition assay. While 5-ANA derivatives resulted inactive on …
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Experimental and computational approaches for control and prediction of solid-state of pharmaceuticals
… forms of clozapine and 16 novel solid forms of olanzapine were obtained by utilising a total of only ~640 mgs of API and ~65 ml of solvents. A statistical model with ~70% prediction accuracy has been built for predicting the crystallisability of small organic molecules. This model is first of …
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Unravelling Variability in Antidepressant Outcomes using Pharmacogenetic and Pharmacokinetic Strategies
… depression were treated with sertraline and olanzapine for up to 20 weeks, followed by a randomized phase of 36 weeks when participants received sertraline and olanzapine or sertraline and placebo. Using genome-wide association studies (GWAS), we identified suggestive genomic associations for …
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Variability in Pricing of Generic Antipsychotic Medications Used in the Treatment of Schizophrenia at Community Pharmacies in the Kansas City Metropolitan Area
… antipsychotic medications (risperidone, olanzapine, quetiapine, ziprasidone, and aripiprazole) recommended for first line therapy in the treatment for schizophrenia is lacking. Pharmacy-level variability in retail cash pricing for five generically available second-generation and one …
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The impact of antipsychotic drugs on the expression of genes associated with obesity
… expression was also altered by treatment with olanzapine in most obesity-related genes tested but only in one gene when treated with risperidone. Treatment with 5-HT promoted an increase in mRNA expression of some obesity-related genes, which was similar to the treatment with 0.25 μg/ml …
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The Discriminative Stimulus Properties of the Atypical Antipsychotic Clozapine in C57BL/6 Mice
… data show that the atypical antipsychotics olanzapine, risperidone, ziprasidone but not the typical antipsychotic haloperidol fully substitutes for clozapine. The present study demonstrated that the atypical antipsychotics quetiapine, sertindole, zotepine, iloperidone, melperone fully …
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A Description of Psychotropic Medication Use in Institution and Community Settings in Ontario.
… antipsychotics were risperidone, quetiapine and olanzapine.
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Drug-cyclodextrin complexes: an approach to enhance the solubility and dissolution properties of poorly soluble drugs
… indomethacin and methyl-β-cyclodextrin; olanzapine and methyl-β-cyclodextrin; flurbiprofen and methyl-β-cyclodextrin) in order to enhance the apparent solubility and dissolution properties of drugs. Specifically, the effectiveness of supercritical carbon dioxide processing for the …
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A NOVEL PIPELINE FOR DRUG DISCOVERY IN NEUROPSYCHIATRIC DISORDERS USING HIGH-CONTENT SINGLE-CELL SCREENING OF SIGNALLING NETWORK RESPONSES EX VIVO
… treatment with the atypical antipsychotic olanzapine. We then validate the abnormal cell signalling responses in PBMCs from an independent cohort of drug-naïve first-onset schizophrenia patients (n=25) relative to controls (n=25) and investigate the specificity of the abnormal PBMC …
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Investigation of the Effects of Antipsychotics on CNS Insulin-mediated Brain Glucose Uptake using 2DG Autoradiography
… autoradiography. We discovered that olanzapine attenuated central insulin-mediated cerebral glucose uptake across various regions of the brain. We also investigated whether this was a class or dopamine 2 receptor (D2R) antagonism driven effect by using four additional APs …
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Investigation of Psychotropic Drugs for the Treatment of Glioblastoma
… of the drugs and indicated that treatment with olanzapine extended the life-span of the rats beyond that of temozolomide. Investigation of the mechanism of action of these drugs indicated that they affect intracellular cholesterol trafficking and the intermediates of the cholesterol synthesis …
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Nucleation and growth of pharmaceutical crystals
… characterisation of prenucleation clusters in olanzapine (OZPN) aqueous solutions, their role in non-classical heteronucleation of OZPN hydrates and during crystal growth mechanism.;Atomic force microscopy studies of the (100)OZPNI face of OZPN I crystals in contact with water show the …
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The gut microbiota as a contributing factor to antipsychotic-induced weight gain and metabolic dysfunction
… antibiotics can attenuate certain aspects of olanzapine and risperidone–induced metabolic dysfunction, in particular fat deposition and adipose tissue inflammation. Mechanisms underlying this novel link appear to involve energy utilization via expression of lipogenic genes as well as reduced …
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