Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Offspring health"”.
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The Impact of Antenatal Exercise in Overweight and Obese Women on Maternal and Offspring Health
… obesity in pregnancy is associated with adverse health outcomes in both the mother and the offspring. It is not well established whether antenatal exercise can improve these outcomes. Hypothesis We hypothesized that antenatal exercise in overweight and obese women could improve offspring and …
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The impact of mouse placental endocrine function on fetal resource allocation and adult offspring health
… as postulated by the Developmental Origins of Health and Disease (DOHaD) hypothesis, abnormalities in fetal nutrient supply and growth can programme the offspring to develop altered metabolic health in later life. Despite this, little is known about the role of the endocrine placenta in fetal …
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The Role of Mouse Placental Endocrine Function on Offspring Metabolic Health
… mellitus (GDM). The Developmental Origins of Health and Disease (DOHaD) theory suggests that adversity in prenatal and early life, influence offspring health. Multiple studies have now shown that the maternal environment (GDM, diet and stress) can affect placental growth, birthweight, and …
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Examining the placenta’s role in neurodevelopment in the context of maternal obesity
… likely contributes to programming of long-term offspring health, in particular neurodevelopment. Various maternal exposures, such as psychosocial stress, diabetes, infection, and high body mass index (BMI) are associated with higher risks of impaired neurodevelopment in the offspring. One third …
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Impacts of maternal dietary fat intake on fetal development in an ovine model
… development and may have lasting effects on offspring health and disease risk trajectory. Intake of dietary fatty acids has been a major focus in the biomedical and epidemiological literature given concerns about the adverse effects of excessive fat intake on cardiometabolic risk and the …
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Enduring Effects of Early Life Inflammation on Stress-related Microglial, Neuronal and Behavioral phenotypes
… neonatal infections, however effects on offspring health resulting from the combination of these stressors have yet to be investigated. GR expression in neurons and microglia regulate anxiety behaviors and their densities can influence this regulation. Microglia, neuro-immune cells, …
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Fetal Programming of Newborn TL
<p>Healthcare costs associated with treatment of the most prevalent age-related diseases is astronomical, approximately $568 billion in 2010. As these costs are projected to rise as the older-adult population grows, it is of increasing urgency to elucidate the origins of these diseases. Telomere …
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The neurodevelopmental impact of stress and inflammation during pregnancy: influence of the maternal microbiome and gut health
… optimal neurodevelopment of the fetus. The health of the developing fetus is also determined by the maternal microbiome, which has been previously shown to shape and modulate long-term offspring outcomes. The unique bidirectional relationship between the maternal microbiome and immune system …
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Placental (Mal)Adaptation in Maternal Obesity: Immune-Mediated Regulation of Placental Nutrient Partitioning and Fetal Growth
… during pregnancy and can programme the offspring for elevated risk of non-communicable diseases. Obesity is also linked with chronic low-grade inflammation. The placenta plays a central role in mediating metabolic and inflammatory effects of the gestational environment on fetal growth …
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Nestling Diet, Quality, and Post-fledging Survival: Comparing Two Species of Aerial Insectivores in a Gradient of Agricultural Intensity in Saskatchewan, Canada
… terrestrial) can be an important determinant of offspring health and development which, in turn, can have lasting effects on future life-stages, including the post-fledging transitional period to independence. In 2020 and 2021, using a comparative approach between two sympatric species, Barn …
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Influence of a physical exercise program, physical activity, sedentarism, body composition and physical fitness during pregnancy on body composition, physical fitness and neurocognition of the offspring: the gestafitos project
… during pregnancy to improve maternal and offspring health outcomes, as it has been shown to contribute positively to a better metabolic intrauterine environment. Body composition is a strong determinant of birth complications and future diseases. Exercise during pregnancy has been shown to …
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Maternal rumen-protected methionine supplementation alters dairy calf development, postnatal growth, plasma biomarkers, and liver one-carbon metabolism
… of the most important factors that can affect offspring health and performance. Methionine, besides being the first limiting amino, is an important precursor of antioxidants and methyl donor. Therefore, our objectives were to investigate if increasing methionine (Met) supply during …
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Effect of Inflammation in Pregnancy on Maternal and Offspring Cardiovascular Systems
… with an increased risk of future maternal and offspring cardiovascular disease (CVD). Murine studies have revealed that inflammatory pregnancies are associated with the acquisition of risk factors for CVD, but not overt disease. Therefore, a second inflammatory stimulus, such as one induced by …
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Exploring the sex-specific programming of cardiovascular disease by maternal obesity and assessing potential interventions to the mother
… is known to have a negative impact on maternal health, pregnancy outcome, and the long-term cardiometabolic health of her offspring. Maternal interventions in obese pregnancy are needed to prevent transmission of poor cardiometabolic outcomes between mother and child. Maternal exercise in obese …
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Using human genomics to decipher biological mechanisms underlying reproductive ageing and fertility in women
… timing is highly variable and can impact health outcomes in later life. One in 100 women experience menopause before the age of 40. As natural fertility begins to decline 10 years prior to menopause, the age of menopause impacts reproductive options for many women, leading to increased …