Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 75 for “"Oesophagus"”.
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The involvement of bacteria in the progression of Barrett’s oesophagus to adenocarcinoma of the oesophagus
Barrett's oesophagus (BO) arises from chronic gastro-oesophageal reflux disease(GORD). Patients have an increased risk of adenocarcinoma (ADC), which is the sixth most common cause of cancer mortality in the UK. All ADC develop from BO, and over the last twenty years there has been a marked …
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Clonal Dynamics in Barrett's Oesophagus and Oesophageal Adenocarcinoma
… has a metaplastic pre-cursor lesion, Barrett’s oesophagus (BO), which can be monitored and effectively treated if dysplasia develops. Screening for BO could improve outcomes but needs to be balanced with the consequences of over-diagnosis and over-treatment since most BO will not progress. BO is …
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Biomarkers of Progression from Barrett's Oesophagus to Oesophageal Adenocarcinoma
Barrett’s oesophagus (BO) is a pre-malignant condition for oesophageal adenocarcinoma (OAC) [1], the incidence rate of which has been rising dramatically over the last four decades in the western world [2, 3]. Survival of an OAC affliction is poor, and one of the ways to improve this would be by …
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Peptic ulceration of the oesophagus in combination with partial thoracic stomach
The subject - "Peptic Ulceration of the Oesophagus in combination with Partial Thoracic Stomach" - is one which has been recognised only within the past few years. It has been my fortune, as radiologist to a large teaching hospital, to find over twenty cases during the past five years. The thesis …
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Investigating the origins of polyploidy in Barretts oesophagus and oesophageal adenocarcinoma
… the origin(s) of polyploidy in Barrett’s oesophagus and Oesophageal adenocarcinoma. Oesophageal adenocarcinoma (OEAC) is preceded by the condition Barrett’s oesophagus (BE), in which the stratified squamous mucosa of the oesophagus becomes damaged from exposure to stomach acid, resulting …
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Characterisation of Copy Number Changes in the Progression of Barrett’s Oesophagus
… of oesophageal adenocarcinoma is Barrett’s oesophagus (BE). To diagnose those patients who will progress to cancer early to improve the dismal survival rate of oesophageal adenocarcinoma, patients with BE undergo regular endoscopic surveillance. The vast majority of patients, however, will …
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Defining Epithelial Cell Fate Dynamics of the Oesophagus during Postnatal Development and Homeostasis
… I was able to identify that the postnatal oesophagus is defined by a differential growth, leading to the build-up of longitudinal mechanical strain as the tissue matures. To further study the relevance of tissue strain for epithelial cell behaviour, I developed and applied an in vitro …
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Monitoring Tissue Function Dynamics in vitro with Bioelectronics: Towards Understanding Barrett’s Oesophagus Pathogenesis
Barrett’s oesophagus (BE) is a non-malignant, specialised intestinal metaplasia of the oesophageal mucosa and a precursor of oesophageal adenocarcinoma (EAC). EAC is a particularly aggressive cancer with a high mortality rate, and as such, early intervention and prevention is considered to be …
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Effectiveness of palliative measures in treatment of dysphagia of cancer of the oesophagus
Cancer of the oesophagus,one of the most common cancers amongst the black population in South Africa with "cure" in this condition often considered as a "fortunate accident" by many experts in the field of oncology due to its late presentation and common occurrence of metastasis at presentation. …
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SIGNALLING TISSUE RENEWAL AND CRYPT SURVIVAL IN THE HUMAN COLONIC EPITHELIUM AND BARRETT’S OESOPHAGUS
… cancer and inflammatory diseases. Barrett’s oesophagus is an intestinal metaplasia arising in response to inflammation and ulceration provoked by gastroesophageal reflux. Detailed knowledge of the processes and signalling pathways involved in tissue renewal in Barrett’s oesophagus is still …
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Integrating Epidemiological and Genomic Factors to Inform Outcomes in Barrett’s Oesophagus and Oesophageal Adenocarcinoma
… and its prognosis remains poor. Barrett’s oesophagus (BO) is considered the precursor to OAC, however, BO is not apparent adjacent to tumour in nearly half of OAC patients. We have previously demonstrated that patients with BO-adjacent tumours (BO+ve OAC phenotype) have a favourable …
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‘A World Where People No Longer Fear Cancer’: An Anthropology of Barrett’s Oesophagus in the UK
… a new device used to screen people for Barrett’s oesophagus (a condition that increases a person’s risk of oesophageal cancer), as an example of one such cancer control practice. On the basis of long-term ethnographic fieldwork with professionals working to implement this test in the NHS and with …
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Multi-omic characterisation of Barrett’s oesophagus reveals a molecular continuum in the progression to oesophageal adenocarcinoma
Barrett’s oesophagus (BE) is the main risk factor for the development of oesophageal adenocarcinoma (OAC) yet only 0.4%/year of non-dysplastic (ND) BE cases progress to cancer (Bhat et al., 2011). In this thesis I present the first comprehensive, multi-omics study comparing indolent, …
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The Use of 2D and 3D Models to Study Competition in the Context of Barrett’s Oesophagus and Oesophageal Adenocarcinoma
… an identifiable pre-cursor stage, Barrett’s Oesophagus (BO). BO can progress via the accumulation of further genetic and morphological changes into low-grade and then high-grade dysplasia. This development process is believed to take place over many years or decades and offers multiple …
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Exploring the role of BCL11A in the oesophagus and mammary gland using in vivo lineage tracing and 3D organoid models.
In the pursuit of effective cancer therapy, extensive disease heterogeneity remains one of the largest problems facing researchers. NGS sequencing has helped to identify specific markers of disease to deconvolute some of this heterogeneity, indeed it has also enabled the similarities of some …
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A Study to Investigate Factors Involved in the Development of Oesophageal Carcinoma
… patients with the precursor lesion, Barrett's oesophagus. The current study considered the hypothesis that patients with Barrett's oesophagus were deficient in antioxidants compared to reflux patients without evidence of Barrett's oesophagus.<br/><br/>Bcl-2 is an inhibitor of apoptosis or …
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