Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Oesophageal squamous cell carcinoma"”.
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Analysis of driver gene mutations in oesophageal squamous cell carcinoma
Oesophageal cancer (OC) is the eleventh most diagnosed cancer and the seventh most common cause of cancer-related deaths worldwide. The two main subtypes are oesophageal adenocarcinoma (OAC) and oesophageal squamous cell carcinoma (OSCC). OAC is more common in North America and Europe, while OSCC …
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Investigating the role of growth hormone receptor in oesophageal squamous-cell carcinoma.
Squamous-cell carcinoma of the oesophagus is a formidable disease which poses a significant health risk in developing countries where incidence is high and survival is low. Investigating the poorly understood mechanisms involved in oesophageal tumourigenesis may provide a platform to develop …
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Investigating Prostaglandin E2 activation of the p38 pathway of oesophageal squamous cell carcinoma
Background, aim and objectives: Oesophageal squamous cell carcinoma (OSCC) is an endemic disease. Epidemiologic studies driven by investigation of Sammon in a region with one of the highest prevalence, linked a predisposition to develop OSCC to a high consumption of maize via reflux disease and …
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The analysis of genetic aberrations in South African oesophageal squamous cell carcinoma patients
… are gastrointestinal tract (GIT) cancers, with oesophageal cancer being the 8th most common cancer. Oesophageal squamous cell carcinoma (OSCC) occurs in the upper to mid oesophagus and is present at high incidence in developing countries including South Africa. There are no early symptoms, …
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Investigating the Role of Cigarette Smoke and Alcohol in Oesophageal Squamous Cell Carcinoma
… about 18.1 million new cancer cases worldwide; oesophageal cancer (OC) ranks seventh out of all incidence cases and sixth in mortality. OC has a poor 5-year overall survival rate of about a 15% (Arnal et al., 2015). This occurs as OC is largely asymptomatic and patients often seek medical …
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Identification of genetic polymorphisms associated with oesophageal squamous cell carcinoma risk in South Africa
Oesophageal squamous cell carcinoma (OSCC) is a complex disease, determined by the interaction of genetic factors with environmental risk factors. In South Africa, OSCC is a major malignancy occurring with high incidence in the Black and Mixed Ancestry populations. Previous studies by our research …
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Functional analysis of N-MYC downstream regulated gene 1 (NDRG1) in Oesophageal squamous cell carcinoma
Oesophageal squamous cell carcinoma (OSCC) ranks as one of the deadliest tumours with a high incidence in developing countries in the areas of Southern Africa, Middle East and Far East. Moreover, its unfavourable prognosis is further complicated by the lack of knowledge about the molecular biology …
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Enhancing Early Detection of Oesophageal Squamous Cell Carcinoma Through Shallow Whole-Genome Sequencing and Non-Endoscopic Sponge Sampling
The incidence of oesophageal squamous cell carcinoma (OSCC) remains high, accounting for approximately 90% of the nearly half-million annual cases of oesophageal cancer globally. Although effective, conventional upper endoscopy is invasive and costly, limiting its widespread use for screening …
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The role of viral sequences in genetic aberrations and malignant transformation
… Approximately 500,000 of these deaths are due to oesophageal squamous cell carcinoma (OSSC) alone, one of the major cancers in Eastern and Southern Africa, Latin America and Asia. Previous studies have shown HPV DNA to be integrated in nearly 40% of oesophageal tumours whereas it was present in …
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Investigation into the effects of the tobacco smoke procarcinogen benzo[a]pyrene on gene expression profiles in oesophageal cancer
… is a major risk factor in the development of oesophageal squamous cell carcinoma (OSCC). Benzo[a]pyrene (BaP) is a tobacco smoke procarcinogen that is metabolically activated into the carcinogenic benzo[a]pyrene diol-epoxide (BPDE) by the CYP1 family of cytochrome P450 enzymes. BaP is a ligand …
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Helicobacter pylori and its Association with Gastric and Oesophageal Carcinomas
… and the development of gastric and oesophageal carcinomas. Nested case-control studies were performed in the Malmö Preventive Medicine cohort consisting of 32,906 subjects. Tumour cases were identified by the Swedish National Cancer Registry. H. pylori infection was identified …
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Proliferative and survival pathways in oesophageal cancer
Oesophageal squamous cell carcinoma (OSCC) is the 8th most common cancer worldwide with high incidence in areas that include China, Iran and South Africa. The current treatment available for OSCC does not significantly enhance patient survival. A better understanding of proliferative and survival …
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Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer
Although the incidence and mortality due to the oesophageal squamous cell carcinoma (OSCC) in Black South Africans is extremely high, very little is known about the aetiology and molecular biology of the disease. In order to make a contribution to the understanding to the causes of this disease we …
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Altered protein expression patterns in oesophageal cancer
Oesophageal squamous cell carcinoma presents a significant health burden in South Africa. It is one of the most common causes of cancer-related mortality of South African black males, as a result of its asymptomatic progression leading to late diagnosis and poor prognosis. The aim of this study was …
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The role of human papillomavirus (HPV) E6 proteins as a risk factor for oesophageal cancer
Oesophageal squamous cell carcinoma (OSCC) is a major cancer in South Africa, affecting mainly black males. Several risk factors for OSCC have been reported but this study focuses on the role of human papilloma virus (HPV) in the development of OSCC. HPV is a well-known risk factor for cervical …
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Factors Influencing the Somatic Mutational Landscape of Ageing Squamous Epithelium
… is illustrated by keratinocyte skin cancers and oesophageal squamous cell carcinoma, which both develop from squamous epithelium, yet are remodelled during ageing by very different mutagenic processes and environmental exposures. In this thesis, I investigate the influence of cancer risk factors …
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Molecular mechanisms involved in the anticancer activity of BISPMB in oesophageal cancer cells
… 12 times more active at inhibiting the growth of oesophageal squamous cell carcinoma WHCO1 cells and displays selectivity for cancer cells over normal cells. BisPMB is therefore attractive as a potential cancer therapeutic. In this study, bisPMB was found to inhibit WHCO1 cancer cell proliferation …
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Epidemiological risk factors, related biomarkers and oesophageal adenocarcinoma survival
The demographics of oesophageal cancer have changed dramatically over the last 30 years. Oesophageal squamous cell carcinoma remains the predominant subtype worldwide, but in the western world the incidence of oesophageal adenocarcinoma has surpassed that of oesophageal squamous cell carcinoma and …
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Oesophageal squamous cell carcinogenesis : a study of cell cycle regulatory proteins by immunohistochemistry
Oesophageal squamous cell carcinoma (OSCC) is a highly malignant tumour that has a poor prognosis and shows marked regional variation in its incidence, implicating environmental factors. South Africa is one of several countries that has areas of high incidence. The exact aetiopathogenesis of OSCC …
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The Role of tRNA methyltransferases in Cancer
… have emerged as pivotal regulators of cellular homeostasis, stress adapta- tion, and disease, particularly within the context of cancer. Among these, tRNA modifications play a crucial role in maintaining translational fidelity and supporting cancer cell survival under adverse …
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