Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 92 for “"Oedema"”.
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On Brain Oedema
… flow and oxygenation. In this thesis, brain oedema and its origins are investigated in experimental models of brain trauma and bacterial meningitis, and in patients suffering severe head injury. The studies are focused on fluid therapy, blood-brain barrier permeability changes, and their …
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Plasma proteins and cardiac oedema
One of the factors in the causation of cardiac oedema is a depletion of the plasma proteins which results in a fall in the colloid osmotic pressure of the blood. This depletion is due principally to malnutrition, and it is suggested that cases of cardiac oedema should be given diets containing the …
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Diabetic macular oedema: the role of steroids and VEGF
… in controlling diabetes, diabetic macular oedema remains the leading cause of blind registration in the working population in England and Wales. The only proven effective treatment for diabetic macular oedema is laser photocoagulation. However this treatment has limited benefits since it …
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The impact of post operative oedema on clinical recovery and its potential causes
… manifest clinically as central and or peripheral oedema. The incidence of oedema in patients undergoing routine major abdominal surgery (MAS) is unknown and there are no objective means of quantifying or monitoring its presence. Furthermore, the aetiological factors responsible for post-surgical …
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Characteristic distribution of peripapillary retinal nerve fibre layer oedema in acute methanol-induced optic neuropathy
… of peripapillary retinal nerve fibre layer oedema in acute methanol-induced optic neuropathy (Me-ION). Methods: This retrospective case series study included four adult patients with acute Me-ION treated at Groote Schuur hospital in Cape Town during the national alcohol ban amid the COVID-19 …
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An investigation into the prehospital diagnosis, patient characteristics and treatment of cardiogenic acute pulmonary oedema (APO) patients: A scoping review
… and treatment of Cardiogenic Acute Pulmonary Oedema (CAPO) in the prehospital setting and to also discuss the application and relevance of these findings to low to middleincome countries (LMICs). Specific practice guideline elements that were reviewed included clinical presentation, timely …
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The role of substance P in experimental intracerebral haemorrhage.
… main SP receptor (neurokinin-1 (NK1)) reduces oedema and improves functional outcome in both settings. As this thesis details, we hypothesised that SP plays a similarly deleterious role following intracerebral haemorrhage (ICH). We further hypothesised that the post-ICH effects of intracerebral …
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The mechanisms of aquaporin expression and translocation in cerebral pathologies
… range of physiologies and pathologies including oedema, hypertension, diabetes insipidus and cancer. Consequently, AQPs have been highlighted as key drug targets. AQP4 is the most abundant AQP in the central nervous system (CNS), predominantly in CNS glial cells, particularly astrocytes and at …
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Characterising the role of substance P in acute ischaemic stroke.
… stroke therapeutic remains elusive. Cerebral oedema is widely recognised as a common and often fatal complication of stroke that is associated with worsened outcome. However, the exact mechanisms of oedema formation remain unclear, with current therapies largely ineffective in addressing the …
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Routine cranial CT before lumbar puncture in HIV positive adults presenting with seizures at Mitchells Plain Hospital in Cape Town
… lesion that has a measurable volume) or cerebral oedema. Multivariate analysis showed a CD4 count < 50 (p=0.033) to be a statistically significant predictor of patients with a space occupying lesion (SOL) and cerebral oedema. Univariate analysis showed focal signs (p=0.0001), neck stiffness …
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Hypoxia and vascular nitric oxide bioavailability: Hypoximplications for the pathophysiology of high-altitude illness
… mountain sickness (AMS), high-altitude cerebral oedema (HACE) and high-altitude pulmonary oedema (HAPE), though data to date remains scarce. Therefore, there is a clear need for further work to address the role of NO in the pathogenesis of high-altitude illness.Aims: There were two primary aims …
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Pharmacological modulation of insulin resistance - benefits and harms
… of TZDs; (ii) risk factors for TZD-associated oedema in T2DM; and (iii) the potential for metformin as adjunct therapy in T1DM.<br/><br/>Methods: (i) A small clinical study characterising TZD tolerant and intolerant<br/>individuals with T2DM; (ii) A population-based epidemiological study of TZD …
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Aetiologie, Klinik und Prognose bei männlichen Rindern mit Harnröhrenverschluss
… with a distended urinary bladder or subcutaneous oedema or intraperitoneal urine accumulation are considered to be diagnostic. Not only the parameters of the special but also of the general physical examination turned out to be important in the evaluation of the stage of the disease and the …
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The retinal microvasculature as an early indicator of chronic disease risk in older populations
… for the treatment of diabetic macular oedema and neovascular age-related macular degeneration, on long-term renal outcomes was evaluated in a cohort with diabetic macular oedema. <br/><br/>There was no evidence detected to suggest that regular long-term intravitreal vascular endothelial …
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Lymphoedema in a remote and rural area: An investigation into the prevalence of lymphoedema and its effect on daily living and quality of life in a remote and rural area in the far north of Scotland.
… to the study: The long term maintenance of lymphoedema depends on a daily regime of these physical therapies, which lend themselves to self-management by those with the condition (Lymphoedema Framework, 2006). It has been widely recognised in the literature for many years, e.g. Rose et al (1991) …
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The role of mast cells in a mouse model of focal cerebral ischaemia
… in blood brain barrier (BBB) permeability, oedema and neutrophil recruitment. Therefore the hypothesis of this thesis was that mast cells are active in the acute phase of experimental focal cerebral ischaemia, and interact with the brain to potentiate ischaemic pathology by release of a …
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Evaluation of the antinociceptive, anti-inflammatory and antipyretic activities of Ruta Graveolens L. in mice and rats
… test and hot-plate test, the carrageenan rat paw oedema test, and the E. coli-induced pyrexia test, respectively; to investigate the possible mechanisms of the antinociceptive, anti-inflammatory and antipyretic activities of the plant using interaction studies; to determine some secondary …
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Histopathogenesis of eczma
… in the epidermis and exudative in the dermis. Oedema fluid and lymphocytes from the upper dermis then force their way into the weakened epidermis to form vesicles. The degree of the reaction varies considerably in intensity from case to case.
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