Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 88 for “"Odorant"”.
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Odorant receptors: regulation, signaling, and expression
… binding of odorous ligands to G protein-coupled odorant receptors, resulting in the activation of G protein and second messengers that culminates in the generation of action potentials to relay this signal to the brain for odor recognition. This signaling cascade comprises the primary olfactory …
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Concentration-dependent recruitment of mammalian odorant receptors
… of comprehensively identified sets of activated odorant receptors (ORs) across an odorant concentration range inside freely behaving animals. In mammals, this has recently become feasible with high-throughput sequencing-based methods that identify populations of odorant activated ORs in vivo. In …
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Precursors to the potent odorant wine lactone.
This thesis describes the synthesis, hydrolysis and analysis of menthiafolic acid, a precursor to wine lactone in wine. (R)-Menthiafolic acid was synthesised and then taken through acid hydrolyses to confirm its conversion to wine lactone under wine-like conditions and to determine the chirality of …
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Modulation and Ligand Selectivity of Mammalian Odorant Receptors
… of smell starts with the activation of odorant receptors (ORs) by volatile molecules in the environment. Mammalian genomes typically encode large numbers of ORs, with approximately 400 intact ORs in human and more than 1000 in mouse. Central to the question of how olfactory stimuli are …
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The Role of Drosophila Odorant Receptors in Odor Coding
… research, the expression patterns of fly's 62 odorant receptors (ORs) were largely unknown. I set out to understand the rules of connectivity of olfactory sensory neurons and the resulting properties of olfactory circuit. Consequently, we assembled maps of the olfactory neuron projections in …
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Mosquito Odorant Receptors: C-terminal Motifs, Subfamily Expansion, and Function
… olfactory signaling components such as mosquito odorant receptors. This hypothesis is supported by several lines of evidence including the highly divergent and lineage-specific nature of this receptor family. Likely these differences are subtle and will be identified in highly focused studies. …
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Odorant Responses and Courtship Behaviors Influenced by at4 Neurons in Drosophila
… specificity and function. Using a combination of odorant receptor mutant analysis, single sensillum electrophysiology and optogenetics, I have examined the chemical tuning and behavioral consequences of the three at4 olfactory neuron classes. My results indicate that one class, Or65abc neurons, …
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Mechanisms of Volatile Odorant Detection and Corresponding Behavioral Effects in Drosophila
… insect repellents, and food source-derived odorants by primary sensory neurons in Drosophila and the corresponding behaviors generated by these stimuli. To date, the only known volatile pheromone in Drosophila is the male-specific hydrocarbon 11-cis-vaccenyl acetate (cVA). I took a genetic …
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Averaged Evoked Responses to Light and Odorant Under Certain and Uncertain Conditions
… To determine if the averaged evoked response to odorants was similar to the late positive component in the averaged evoked response to lights, both light and odorant were presented under two conditions to see if they would both occur under the same experimental condition and both be absent under …
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Evaluating the Impact of Environmental Conditions on the Cocaine Odorant Methyl Benzoate
… benzoate is widely accepted as the primary odorant VOC in the headspace of cocaine. Currently, there is a dearth of research as to the role of environmental conditions on canine performance, however, a tangential gap in literature lies in the effects of controlled target odor emission in …
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Employing High Probability Gene Choice Elements to Understand Singular Odorant Receptor Expression
… olfactory sensory neurons (OSNs), which express odorant receptors (ORs) that bind to chemical odors in the environment. In order to increase specificity and sensitivity, an essential property in olfaction is for each OSN to express an OR in a monogenic and monoallelic fashion. Out of a large …
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Evolution of the Gr family of gustatory and odorant receptors in mosquitoes
The ability to detect chemical information from the environment is of critical importance to insects, whose ecological and evolutionary boundaries typically revolve around taste and smell. Of the receptors involved in chemoperception, the gustatory receptor (Gr) protein family comprises most of the …
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Two Odorant-Binding Protein Genes in Mosquitoes: Comparative Genomics, Expression, and Function
Insect Odorant-Binding Proteins (OBPs) are small, water-soluble molecules that solubilize hydrophobic odorant molecules in the sensillum lymph and transport them to their cognate receptors in the olfactory receptor neurons. With the availability of the genome sequence of the African malaria …
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A Novel Role for Odorant Binding Proteins in Deactivation of Drosophila Olfactory Neurons
In insects, odorant binding proteins are a large and diverse group of low molecular weight proteins secreted into the fluid bathing olfactory and gustatory dendrites. The best-characterized OBP, known as LUSH, is required in Drosophila melanogaster for the detection of physiological levels of the …
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Getting at the Surface: A Promoter and Coding Sequence Characterization of an Odorant Receptor
<p>Odorant receptors (ORs) are expressed by mature olfactory sensory neurons (OSNs), in a monogenic and monoallelic fashion (singular gene choice). It has been repeatedly published that the singular expression of ORs is a consequence of epigenetic regulation. The model invokes the depositing of …
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Methoxypyrazine removal in grape juice: Development of a removal system using odorant and pheromone binding proteins coupled with bentonite fining
… methoxypyrazines from grape juice. The piglet odorant binding protein (plOBP) and mouse major urinary protein (mMUP) were identified, cloned and expressed in the Pichia pastoris expression system. Protein expression was induced using methanol and the proteins were subsequently purified from the …
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Discovery and Phylogeny of the Odorant Binding and Chemosensory Proteins of Diabrotica Virgifera Virgifera (Coleoptera: Chrysomelidae) and Rhagoletis (Diptera: Tephritidae)
… and their evolution. Evidence suggests that both odorant-binding proteins (OBPs) and neuronal receptor proteins play roles in odorant recognition. One hypothesized function of chemosensory proteins (CSPs) and OBPs is to bind and transport specific odorants to olfactory receptors, thereby acting as …
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Olfactory identification, detection thresholds, and sensitivity in kidney disease patients
… thresholds or elevated thresholds for one odorant, but not others. The current study evaluated the olfactory abilities with participants diagnosed with Kidney Disease for numerous odorants. No significant differences were found in olfactory identification, detection thresholds, or …
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Olfactory working memory: the role of perceived odor name-ability
… the relationship among three factors: perceived odorant name ability, whether the odorant was ingested through a single nostril or both nostrils, and how the odorant is represented in working memory. Participants smelled odorants through the left or right nostril or with both nostrils and then …
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