Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Ocular Tissues"”.
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Rheological Studies of Injectable Thermoresponsive Biodegradable Hydrogels and Porcine Ocular Tissues
… and P(NIPAAm-co-HA-AEMA)], and (ii) biological tissues (porcine ocular tissues). </p> <p>A series of thermoresponsive and biodegradable in situ hydrogel based on N-isopropyacrylamide (NIPAAm) monomer and hydrolytically degradable oligolactate Dextran-lactate-HEMA or Hyaluronic acid (HA)-AEMA …
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Biopharmaceutic and Pharmacokinetic Evaluation of Hesperidin and Hesperetin for Ocular Delivery
… characteristics of hesperidin and hesperetin for ocular delivery, especially with respect to the distribution of these compounds to the posterior segment of the eye. Hesperidin and hesperetin were found to be water insoluble compounds. Although they demonstrated good permeability across the ocular …
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Investigation of ocular drug metabolism and pharmacokinetics using multi-omics and in-situ microdialysis
Ocular drug disposition is governed by a complex interplay of anatomical barriers, local metabolic activity, transporter expression, and tissue-specific physiological processes. However, quantitative understanding of drug-metabolizing enzymes and transporters in ocular tissues remains limited, …
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Lipid Based Frameworks And Topical Ocular Inserts For The Delivery Of Small Molecule Therapeutics To The Posterior Segment Of The Eye
Lipid based systems and topical ocular inserts of various drugs were developed for the intervention/treatment of posterior segment ocular complications. Indomethacin (IN) was developed into solid lipid nanoparticles (SLNs) and Nanostructured lipid carriers (NLCs). Effect of surface …
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Stereoisomeric Prodrugs to Improve Ocular And Oral Absorption of Prednisolone
… D-valine-L-valine-prednisolone (DLP) to improve ocular and oral absorption of prednisolone. These prodrugs have been examined for their interaction with various influx and efflux transporters commonly expressed on corneal and intestinal epithelium. They have been evaluated for their …
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Ocular Iontophoresis of Nanocarriers for Sustained Drug Delivery to the Eye
… study of a corticosteroid in the ocular tissues after transscleral iontophoretic delivery of the mixed micelles was performed. To evaluate the safety of transscleral iontophoresis of the mixed micelles, histological examination of the eye tissues was performed after the mixed …
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Characterisation of 11beta hydroxysteroid dehydrogenase 1 in ocular and orbital tissues
… inflammation. The first line of defence in the ocular tissues includes the mucosal barrier and expression of receptors that recognise pathogen. These mechanisms activate the innate immune response during inflammation, however, in the ‘normal’ eye, immunomodulatory components exist to promote …
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Non-invasive drug delivery to the posterior segment of the eye: Development of formulation strategies and evaluation of ocular distribution and pharmacological activity
… standards for the treatment of posterior segment ocular diseases, they are associated with pain, inflammation, endopthalmitis and infection. So there is a necessity to develop novel noninvasive drug delivery strategies to treat the posterior segment ocular diseases.</p> <p>In the present study, we …
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Inhibition of excitatory neurotransmitter activity by hydrogen sulfide in bovine retina, in vitro
… and signaling molecule that can reduce intraocular pressure (IOP) in normotensive and glaucomatous rabbits in the anterior segment of the eye. Initial studies support a modulatory role for the fast H2S donor compounds, NaHS and Na2S on excitatory neurotransmitter release in the posterior …
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Development and Characterization of Fluocinolone Acetonide Loaded Nanosized Lipid Carriers for Ocular Delivery via Subconjunctival Route: Synergistic Effect of Vitamin a Palmitate
… the delivery of therapeutic molecules into deep ocular compartments has always been a challenging task. In this regard, the main objective of our current investigation was to develop and evaluate the fluocinolone acetonide (FA) loaded nanostructure lipid carrier (FA-NLC) in situ gel for improved …
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Effect of metabolic insult on amino acids in the ciliary epithelium, lens, and retina
Ischaemic insult deprives ocular tissue of oxygen and essential metabolites leading to anatomical and functional changes. One way to gauge the effect of ocular ischaemia is to determine changes in amino acids likely to be modified due to the intricate interrelationship between cellular metabolism …
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Topical Clear Aqueous Nanomicellar Formulations For Anterior And Posterior Ocular Drug Delivery
… high drug concentrations to back-of-the-eye tissues with topical eye drop application to rabbits. Negligible drug levels were quantified in systemic circulation. These nanomicellar constructs efficiently utilize their hydrophilic corona and evade the wash-out into the systemic circulation …
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The Role of Hyaluronan in the Ocular Surface
… matrix (ECM) has a vital role in all tissues of the body, including maintaining ocular surface homeostasis. Hyaluronan (HA) is found in the extracellular matrices of the corneal limbus and meibomian gland (MG). This dissertation evaluated the role of hyaluronan in ocular tissues, …
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Novel Folic Acid Targeted Nanomicelles For Delivery Of Hydrophobic Drugs To The Back Of The Eye
… acid transporters/receptors are expressed in ocular tissues. We conjugated folic acid to vitamin E TPGS to target the receptors in order to increase bioavailability. Structure was confirmed by NMR studies. The size of drug loaded targeted micelles was ~ 12nm. Morphological structure of …
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Development and Characterization of a Topical Ocular Delivery System for Hydrogen Sulfide for the Treatment of Glaucoma
Glaucoma, an ocular neuropathy, is characterized by progressive degeneration of retinal neurons which can ultimately lead to blindness if left untreated. The current therapies for glaucoma provide only symptomatic management by reducing intraocular pressure (IOP), a prominent risk factor for …
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Comparison of conjunctival pedicle flap to corneal adhesion achieved by Tisseel® fibrin glue, ethyl cyanoacrylate adhesive, ReSure® hydrogel sealant, and conventional suturing with 8-0 VICRYL® suture
… a number of sutureless techniques to affix ocular tissues are being explored. Specifically, these approaches include synthetic tissue adhesives, bioadhesives, and hydrogel sealants. The proposed advantages of adhesives over suture, include reduced operative times, watertight seals, decreased …
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Relationships between subtle ocular changes and microvascular complications in people with type 2 diabetes
… damage, is a microvascular bed accessible for ocular imaging, which has developed rapidly over recent years. There is a need for integrated investigations employing new methods to examine changes across different ocular tissues in individuals with T2DM and microvascular complications. Aims: 1) …
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Robotics and Virtual Reality for Optical Coherence Tomography-Guided Ophthalmic Surgery and Diagnostics
… in visualization and manipulation of small ocular tissues or in interpreting intraoperative imaging to guide their actions. This dissertation therefore seeks to advance the state-of-the-art in ophthalmic surgery with regards to manipulation, visualization, and interpretation.</p><p>First, we …
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Investigation of the role of Glil+ cells in retinal angiogenesis and fibrosis.
Background: In ocular diseases such as Age-related Macular Degeneration (AMD) and diabetic retinopathy, dysregulated inflammation in the retina can lead to the formation of a fibrovascular membrane, which can cause severe structural damage to the retina thus leading to severe visual defects and …
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Investigating the functions of PGC-1 isoforms in retinal pigment epithelia metabolism and their implications on age-related macular degeneration
… did not cause cataracts or other damage to the ocular tissues. While statistical significance in gene expression changes was limited due to the small sample size, anti-oxidants GPX1 and TXN2, and electron transport chain gene, ATP50, were found to be potentially induced in the neuro-retina, …
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