Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Ocular Delivery"”.
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Biopharmaceutic and Pharmacokinetic Evaluation of Hesperidin and Hesperetin for Ocular Delivery
… characteristics of hesperidin and hesperetin for ocular delivery, especially with respect to the distribution of these compounds to the posterior segment of the eye. Hesperidin and hesperetin were found to be water insoluble compounds. Although they demonstrated good permeability across the ocular …
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Design and Development of Solid Lipid Nanoparticles for Ocular Delivery of Acyclovir
Background and aim: Ocular infections caused by Herpes keratitis remain the leading cause of infectious blindness in the developed world and there is a need for the development of a novel drug delivery system to improve treatment options. The complex structure of the eye poses several challenges …
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Development and Characterization of a Topical Ocular Delivery System for Hydrogen Sulfide for the Treatment of Glaucoma
Glaucoma, an ocular neuropathy, is characterized by progressive degeneration of retinal neurons which can ultimately lead to blindness if left untreated. The current therapies for glaucoma provide only symptomatic management by reducing intraocular pressure (IOP), a prominent risk factor for …
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Development and Characterization of Fluocinolone Acetonide Loaded Nanosized Lipid Carriers for Ocular Delivery via Subconjunctival Route: Synergistic Effect of Vitamin a Palmitate
… have embarked as an emerging tool for drug delivery applications, the delivery of therapeutic molecules into deep ocular compartments has always been a challenging task. In this regard, the main objective of our current investigation was to develop and evaluate the fluocinolone acetonide …
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Design of nanoplatforms for ocular delivery of SIRT1 agonists in diabetic retinopathy [Progettazione di nanopiattaforme per la somministrazione oculare di agonisti di SIRT1 nella retinopatia diabetica]
… ruolo fondamentale nella protezione dei tessuti oculari, come il nervo ottico e la retina. La ridotta espressione di SIRT1 rappresenta un fattore chiave nella DR, portando a una degenerazione del segmento posteriore dell'occhio sia a livello vascolare che neuronale. Studi presenti in letteratura …
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Development of Polymeric Microparticle-Based Drug Delivery System for Sustained Delivery of H2S for Treatment of Glaucoma
… therapies primarily target to reduce intraocular pressure (IOP), they remain unsuccessful in preventing neurodegeneration associated with glaucoma progression. Therefore, there is a need of a better treatment that can target both - reducing IOP and providing retinal neuroprotection. …
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Exploration of Hypotensive Effects of Novel Hydrogen Sulfide Donors: Mechanisms and Their Delivery
… worldwide, largely influenced by increased intraocular pressure (IOP), which is the most critical modifiable risk factor. Existing therapies frequently focus on a particular pathway, which may limit their long-term effectiveness and reduce patient compliance. This study assessed a multi-targeted …
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Lipid Based Frameworks And Topical Ocular Inserts For The Delivery Of Small Molecule Therapeutics To The Posterior Segment Of The Eye
Lipid based systems and topical ocular inserts of various drugs were developed for the intervention/treatment of posterior segment ocular complications. Indomethacin (IN) was developed into solid lipid nanoparticles (SLNs) and Nanostructured lipid carriers (NLCs). Effect of surface …
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Development of Random Triblock Copolymer Based Nanoparticulate Formulation for Sustained Release of Macromolecules/Biologics in Treatment of Posterior Segment Ocular Diseases
… were synthesized and developed for sustained delivery of macromolecules to the posterior segment of the eye. RTB copolymers of different composition and molecular weights were synthesized. The polymers were evaluated for their molecular weight, purity, crystallinity, functionality, …
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Long Term Ocular Drug Delivery with Novel Pentablock Copolymers; Part I: Composite Nanoformulation of Macromolecules For Back of the Eye Diseases, Part II: Dexamethasone Nanoparticle to Develop an In Vitro Model for Glaucoma
… have been successfully synthesized for long term delivery in the treatment of posterior segment ocular diseases. PB copolymers are comprised of FDA approved biodegradable polymer such as polyethylene glycol (PEG), polycaprolactone (PCL), polylactic acid (PLA) and polyglycolic acid (PGA). PB …
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Non-invasive drug delivery to the posterior segment of the eye: Development of formulation strategies and evaluation of ocular distribution and pharmacological activity
… standards for the treatment of posterior segment ocular diseases, they are associated with pain, inflammation, endopthalmitis and infection. So there is a necessity to develop novel noninvasive drug delivery strategies to treat the posterior segment ocular diseases.</p> <p>In the present study, we …
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SELECTION OF TARGETING MOIETIES DRIVING NANOPARTICLE PENETRATION THROUGH SQUAMOUS PLURISTRATIFIED EPITHELIA
Drug delivery through stratified squamous epithelia is crucial for treating various local and systemic conditions. Nevertheless, the administration through these kinds of epithelia, like the skin, the esophageal membrane, and the corneal membrane, poses significant challenges due to their complex …