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Showing 1 to 2 of 2 for “"Ocular Angiogenesis"”.

  1. The molecular mechanism of action of the antiangiogenic natural product, cremastranone

    Prevention of pathological angiogenesis is a key strategy for treatment of common blinding ocular diseases such as retinopathy of prematurity, proliferative diabetic retinopathy, and wet age-related macular degeneration. The current treatment strategies are associated with partial vision loss and …

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  2. Mechanistic and therapeutic evaluation of a novel antiantiogenic small molecule

    … repeated injections of anti-VEGF drugs can cause ocular and systemic side effects, and about 30% of wet AMD patients are non-responsive. There is thus an unmet need to develop VEGF-independent antiangiogenic molecules to complement or combine with existing medications. I studied SH-11037, a novel …

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