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Showing 1 to 17 of 17 for “"Oct-4"”.
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Part One. Synthesis and Reactivity of Tetracyclo(3.3.0.0(3,6).0(2,8))oct-4-Yl Derivatives. Part Two. Reactivity and Degenerate Rearrangement of Tricyclononadienyl Derivatives
Made available in DSpace on 2014-12-10T23:01:29Z (GMT). No. of bitstreams: 1 7310092.pdf: 3960750 bytes, checksum: 8bd9c4c96c502d23f1824a807dc30114 (MD5) Previous issue date: 1972
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Biology of adult human normal and leukaemia CD133+ stem cells
… presence of CD133 and embryonic stem cell marker Oct-4 positive stem cells in adult human normal and malignant tissues, including normal brain tissues, normal and malignant bone marrow stem cells; and evaluated the anti-acute myeloid leukaemia (AML) effect of 5 novel synthetic ajoene compounds …
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SF-1, BUT NOT DAX-1, PREVENTS P19 CELLS FROM DIFFERENTIATING TO EITHER TROMA-1 OR TUJ1 POSITIVE CELLS UPON RA-TREATMENT
… prevented the RA-dependent loss of Oct-4, DAX-1 and the increase in COUP-TFI, COUP-TFII, and Ets-1 mRNA levels during the commitment stages of both endodermal and neuronal differentiation. Surprisingly, continued expression of SF-1 for seven days caused a RA-independent loss of Oct-4 …
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Fundamental differentiation and growth characterization of murine embryonic stem cells in varied culture conditions
… fluorescent protein (GFP) co-expressed by an Oct-4 promoter was analyzed by fluorescence-activated cell sorter (FACS) to obtain such profile. As Oct-4 is an ES cell differentiation marker whose expression varies with pluripotency, GFP expression could simply be measured in these cells to …
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Signaling pathways regulating self-renewal, differentiation, and multipotency of CD133+ umbilical cord blood stem cells
… that grow without differentiating, we focused on Oct-4, a transcription factor essential for self-renewal in ESCs that we previously reported expression in UCBSCs. During our studies, new challenges in the field arose. Two isomers of Oct-4 were discovered, Oct-4A and Oct-4B 3, in which only Oct-4A …
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Analyses of hematopoiesis and lineage commitment from ES and iPS cells
… durch ektopische Expression von Sox-2, Oct-4 und Klf-4 generiert worden waren, aufgrund ihres epigenitischen Gedächtnisses in vitro effizienter in hämatopietische Zellen differenzieren als ES-Zellen. Erstaunlicherweise war die Effizienz der Differenzierung von iPS-Zellen im Vergleich zu …
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Management of summer grazed alfalfa
… great. There were no differences in IVDMD. On 1 Oct., 4-week and conventional grazing systems had reduced yields, plant height, tiller number, and root total nonstructural, but had no significant effect on forage quality. Conventional grazing resulted in the least damage to yield and productivity …
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REGULATION OF TELOMERASE EXPRESSION IN STEM CELL REPROGRAMMING
… of genes associated with pluripotent cells, Oct-4, SOX2, and NANOG. Together, our data suggest that while the cell surface profile of ASCs do not distinguish them from normal fibroblasts and their lack of telomerase shows their limited proliferation capacity, the expression of genes closely …
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Development of 3D multicellular liver organoids derived from human induced pluripotent stem cells to model antiretroviral therapy induced liver injury
… ALB and HNF4-α), reduction in pluripotency (OCT-4, Nanog, and Sox2) and the definitive endoderm (SOX17 and GSC) markers. Flow cytometry using EpCAM, CD166 and CD68 antibodies indicated that HLOs comprise of 60,4% EpCAM+ cells, 11,2% EpCAM-/CD166+ cells and 5% EpCAM-/CD68+ cells, respectively. …
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The effects of environmentally relevant toxicants on female reproduction and embryo development
… stages. Also, embryo fragmentation was assessed. Oct-4 expression (4 cell stage), E-cadherin (8-cell and blastocyst), micronucleation (4-cell, 8-cell, blastocyst), and blastocyst cell populations of the inner cell mass (ICM) and trophectoderm (TE) was analyzed by immunofluorescence (IF) staining …
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Investigating The Roles of The P63 Isoforms In The Microrna Biogenesis Pathway
… markers of pluripotency, including Sox2, Oct 4 and Nanog; however, genome-wide analysis revealed a novel profile of genes that are common between <em>ΔNp63 <sup>-/-</sup> </em>epidermal cells and embryonic stem cells. I also found that mouse cells depleted of <em>ΔNp63</em> form chimeric …
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COMPARISON OF EQUINE BONE MARROW-, UMBILICAL CORD MATRIX-, AMNIOTIC FLUID- AND TENDON-DERIVED PROGENITOR CELLS
… presence of antigens such as CD44, CD105, CD29, Oct-4, c-Myc, SSEA4 and HLA-ABC, whereas they were negative for CD34 and HLA-DR. These cells, differentiated into osteogenic, adipogenic, chondrogenic and tenogenic lineages confirming the nature of mesenchymal stem cells. These findings suggest …
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Fibronectin peptides and murine embryonic stem cells : an in vitro study
… there was a transient increase in the number of Oct-4, Brachyury and Nestin transcripts. Up regulation of these genes is known in some cases to come from a pro differentiation signal. However concomitant with these transcriptional up regulations, the levels of Nanog, the gene well known to resist …
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Developmental Regulation of Prion Expression in Cattle and Mouse Embryonic Stem Cells
… negatively correlated with pluripotency marker Oct-4 (r= -0.85) confirming that mESC had indeed differentiated. To provide a more robust system for assessing the role of PrPC in neural differentiation, mESC were cultured with or without retinoic acid (RA) to encourage differentiation into neural …
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Hypoxia regulated pathways in urological malignancies
… genes (BNIP3, CAIX, CyclinD1, GLUT1, LDH5, Oct-4 and VEGF) was assessed.<br/>Comparison was made with tumour angiogenesis (CD31), tumour stage, Fuhrman grade,<br/>maximum tumour diameter and patient survival. Further work in this thesis analysed a series of<br/>paired VHL (functional and …
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Oct4 and Sox2 regulate methylation at the Igf2/H19 imprinting control region
… correlated with mutations in one of the pair of octamer binding sites within the ICR. Using a tissue culture system, we found that both octamers were required for transgene hypomethylation in F9 cells and that Oct4 was present at the endogenous ICR. In addition, each of the octamers is flanked by …
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Phenotypic analysis of human stem cells and their differentiation potential towards pancreatic cells
… also expressing the stem cell markers Nestin and Oct-4. Several CB-HSCs expressed SOX-17, GPR40, and Nestin. ASCs expressed SOX-17, in addition to the characteristic ASC stem cell markers CD29 and CD90. The expression of pancreatic markers by undifferentiated HASCs, CB-HSCs, and ASCs indicates …