Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Oatp"”.
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Age-Associated Expression Patterns of OATP 1B1 and OATP 1B3 and Their Effect on the Disposition of Fexofenadine
… the biomembranes of the drug removal organs. OATP1B1 and OATP1B3 are transporters on the sinusoidal membrane of the liver which work in concert with the drug metabolizing enzymes as part of the drug removal process. It is known that the development of each drug metabolizing enzyme follows a …
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The significance of OATP and CYP450 in statin-flavonoid interactions
… myopathy and the possible significance of OATP transport, CYP450 metabolism and mevalonate synthesis” reviews what is currently know about how flavonoids may interact with statin hepatic transport and metabolism, identifies what flavonoids are inhibitors of these pathways, how this compares …
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Role of Membrane Transporters in Drug Delivery, Drug Disposition And Drug-Drug Interactions
… the role of hepatic uptake transporters (OATP-1B1 and -1B3) in governing the disposition of tyrosine kinase inhibitors (TKIs). Since selected TKIs are the substrates and/or inhibitors of OATP-1B1 and -1B3 expressed in hepatic tissue, these compounds can be regarded as molecular targets for …
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Targeting Organic Anion Transporting Polypeptide 1A4 (Oatp1a4) for Effective Drug Delivery at the Blood-Brain Barrier
… (i.e., organic anion transporting polypeptides (OATPs in humans; Oatps in rodents)) have been investigated as strategies that can improve blood-to-brain drug transport and optimize treatment of CNS diseases. Indeed, direct pharmacological inhibition of P-gp using small molecules or selective …
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Structural and functional investigation of the organic anion transporting polypeptide 1B1 (OATP1B1)
… The organic anion transporting polypeptides (OATPs) are a family of transport proteins expressed in a variety of tissues, including absorptive I excretory cells of the liver and kidney. OATPs transport an array of endogenous and xenobiotic compounds including bile salts, thyroid hormones, …
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Molecular mechanisms of thyroid hormone transport: the role of amino acid transporters
… cloned organic anion transporting polypeptide (OATP) family have<br/>been shown to transport TH. Inhibitor studies indicate that both the aromatic<br/>amino acid System T-type transporter, and the broad scope neutral amino acid<br/>transporter System L are mediators of TH uptake into various …
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Imaging Myelin Basic Protein expression in a model of remyelination by Magnetic Resonance Imaging using an Organic Anion Transporter Protein gene reporter system.
… that, by using a novel MRI gene reporter system; OATP, and controlling its expression under a Myelin Basic Protein promoter, OPCs can take up gadolinium based contrast, and be detected using T1 weighted MRI imaging in vitro and ex vivo. Using a constitutively active promoter, transplanted cells …
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Extracullular Atp Regulates Il-1beta Release From Microglial Cells Via Purinergic Receptor After In Vitro Trauma
… release by the purinergic receptor antagonists oATP and suramin decreased cell damage in uninjured mixed organotypic brain cell culture exposed to activated microglia. Taken together, these results suggest that interleukin-1Beta mediated inflammatory events are regulated in activated microglia …
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Docetaxel uptake and modulation of P-gpmediated docetaxel efflux by tyrosine kinase inhibitors in human lung carcinoma cell lines
… mechanism in A549. The contribution of the OATP (organic anion transporting polypeptides) family of transporters to docetaxel uptake in A549 could not be discounted. The existence of transporter-mediated docetaxel uptake in NSCLC cells represents an important new factor in determining the …
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FEXOFENADINE AND ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPs): TRANSPORT AND DRUG-DRUG INTERACTIONS
… was occurring at an enterocyte-expressed OATP. This interaction was reproduced and studied using in vitro model systems. In Specific Aim 1, a specific LC-MS/MS method was developed and validated for the quantification of fexofenadine and the other four probe drugs for use in the remaining …
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BIOCHEMICAL ACTIONS OF A NOVEL CIS-TERPENONE
… (OCT), organic anion transporters (OAT/OATP), and multi-drug-resistant efflux transporters eliminated effects of major groups of these transporters on AFB1 accumulation. The data indicated one or more unidentified proton dependent transport mechanism(s) modulate cellular accumulation of …
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Flaxseed Lignan Metabolites Modulate Hepatocellular Cholesterol Trafficking In HepaRG
… interaction at hepatic uptake transporters (OATP1B) which cannot be ignored as these transporters impact the pharmacokinetics and pharmacodynamics of statins. To address lignan mechanism of action, the effect of the mammalian lignan, enterolactone (ENL), and its metabolite, enterolactone …