Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"OXTR"”.
-
The Role of TET Proteins in the Epigenetic Regulation of Neural Gene Expression and Behavior
… the Tet1Δe4 mouse brain. The oxytocin receptor (OXTR), a neural gene implicated in social behaviors, is suggested to be epigenetically regulated by an unknown mechanism. Interestingly, several human studies have found associations between OXTR DNA hypermethylation and a wide spectrum of …
-
The Diversity of Cortical Interneurons
… Cre lines for candidate marker genes, Rbp4 and Oxtr, to investigate their cell types and functional roles by using Cre/loxP system. Both Rbp4 and Oxtr Cre are heterogeneous in terms of their neurochemical profiles, but DRP analysis on Oxtr Cre neurons suggested their potential to be a …
-
Novel hypothalamic G protein-coupled receptors involved in the control of reproduction
… of interest were identified; oxytocin receptor (OXTR) and Y4 neuropeptide Y receptor (NPY4R). Both receptors have been shown to have a role in reproduction, however, mutations in neither have been previously implicated in causing KS/nCHH respectively. The aim was to determine whether identified …
-
ASSESSMENT OF RELEVANT MOLECULAR TARGETS WITH THERAPEUTIC SIGNIFICANCE IN CANINE NEOPLASMS.
… FAP, EDB+FN, KIT (CD117), PDGFR-β, and OXTR. These molecules are involved in tumor progression, stromal remodeling, angiogenesis, and hormonal regulation. Results confirm that canine tumors can harbor multiple therapeutically relevant molecular targets. FAP and EDB+FN are promising …
-
Neurotransmitter Modulation of Alcohol-Induced GABAergic Signaling in the Central Amygdala
… mRNA expression levels of oxytocin receptor (OXTR), CRF, and serotonin receptors (5-HT1A, 5-HT1B, and 5-HT2C) within the CeA. Electrophysiological findings revealed distinct sex-dependent and subregion-specific mechanisms of modulation. In males, both naïve and dependent, acute alcohol …
-
The Evolutionary Origins of Autism Associated Genes and Their Role in Great Ape Socio-Communicative Behavior
… with ASD. For this study, the focus is on OXTR, AVPR1A, and FOXP2. OXTR is reported to regulate empathy and stress reactivity while AVPR1A is reported to regulate stress management and territorial aggression, as well as social bonding and recognition. FOXP2 is one of the first genes to be …
-
Impact of genetics and phosphorous nutrition on bone metabolism
… not LB, pigs. A trend of increased expression of OXTR was seen in P deficient animals in both genetic backgrounds. Expression of RANKL, BGLAP, OPG, ARAF1, and IGFBP5 was not affected by genetic background or diet. These data suggest that HB pigs were more responsive to dietary P restriction than …
-
Oxytocin and Social Sensitivity: Implications for Vulnerability to Stress and Depressive Symptoms
… a genetic variant on the oxytocin receptor gene (OXTR) moderated the influence of early-life events in relation to later depressive symptoms. In the absence of this polymorphism individuals who experienced early-life maltreatment displayed high levels of depressive symptoms, but this was not …
-
Oxytocin and Genetic Links with Eating Behaviours and Relevant Endophenotypes
… polymorphisms (SNPs) on the OXT receptor gene (OXTR), associated with overeating and relevant behaviours. The present study expanded on this work by analyzing SNPs of the LNPEP, CD38, and OXTG genes. Additionally, sex differences were also examined. A pre-existing data set consisting of 460 …
-
Modulation of Prefrontal Cortex activity and sociability by local interneurons expressing corticotropi-releasing hormone
… circuit. Oxytocin receptor interneurons (OxtR-INs), a subset of somatostatin interneurons first discovered and characterized by Drs. Miho Nakajima, Kun Li, Ines Ibañez-Tallon, and Nathaniel Heintz, were found to mediate prosocial and anxiolytic effects through the release of …
-
Dietary Supplementation of Omega-3 Fatty Acids Influences the Equine Maternal Uterine Environment and Embryonic Development
… greater IL10 (P< 0.001), PTGFS (P=0.05), OXTR (P=0.05) and PLA2G3 mRNA (P= 0.009) and had a tendency for increased SAA (P= 0.08), PTGES (P=0.10) and SLCO2A1 (P=0.10) mRNA abundance. Supplemented mares bred but not pregnant at day 12 in cycle 3 had reduced expression of PTGER2 (P=0.001) and …
-
A multipronged approach to understanding how genes contribute to social behavior in threespine stickleback
… acidic protein (GFAP), oxytocin receptor (OXTR) and tyrosine hydroxylase (TH) in the brain. To enable direct manipulation of genes for social behavior, we focused on aggression. Male sticklebacks demonstrate stereotypical aggressive behaviors during an easily-induced territorial defense. …
-
STUDIO DELL¿ASSOCIAZIONE TRA INQUINAMENTO ATMOSFERICO E DISTURBO DEPRESSIVO MAGGIORE: RUOLO DI MARCATORI BIOLOGICI ED EPIGENETICI
… strong symptoms of anxiety”. Hypermethylation of OXTR was associated with more severe “melancholic / psychotic / no prevalent” type depression. CONCLUSIONS: Exposure to PM10 and PM2.5 did not exert a direct effect on the severity of depressive symptoms, while their influence emerged more clearly …