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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 59 for “"OXPHOS"”.

  1. Oxidative Phosphorylation: A Critical Feature and Novel Therapeutic Target In Melanoma Brain Metastases

    Fischer, Grant, <p>https://orcid.org/0000-0003-3730-9004</p>2021

    … higher expression of oxidative phosphorylation (OXPHOS) genes (including <em>PPARGC1A</em> or <em>PGC1α</em>) than patient-matched extracranial metastases (ECMs). <strong>Thus, the central hypothesis of this dissertation is that </strong><strong>OXPHOS plays a critical role in the pathogenesis of …

    uthsc Repository record

  2. OXIDATIVE PHOSPHORYLATION IN MELANOMA BRAIN METASTASES: A REGULATOR of THE TUMOR IMMUNE LANDSCAPE

    Guerrieri, Renato A, <p>0000-0003-4762-4905</p>2025

    … inhibition of oxidative phosphorylation (OXPHOS) results in increased expression of genes consistent with activated anti-tumor immune responses. <strong>The central hypothesis of this dissertation is that OXPHOS plays a critical role in the pathogenesis and immune regulation of melanoma …

    uthsc Repository record

  3. Genetic and epigenetic influence on oxidative phosphorylation, islet function and type 2 diabetes in humans

    Olsson, Anders HDepartment of Clinical Sciences, Lund University2012

    … ATP production by oxidative phosphorylation (OXPHOS) is known to play a critical regulatory role in glucose stimulated insulin secretion (GSIS). The overall aim of this thesis was to explore the influence of genetic and epigenetic variation on OXPHOS, islet function and T2D in humans. In study …

    lund Repository record

  4. PRUNE_1 INVOLMENT IN TNBC ENHANCING CANCER METABOLISM

    ASADZADEH, FATEMEHUniversità degli Studi di Milano2025

    … high glycolytic and oxidative phosphorylation (OXPHOS) activity, contributing to poor prognosis and metastasis. The ATP5A1 protein, a key component of mitochondrial ATP synthase, plays a central role in energy metabolism and is linked to cancer-specific metabolic alterations, including the …

    milano Repository record

  5. Disassembly of electron transport chain complexes drives macrophage TLR responses by reprogramming metabolism and translation

    Su, YangMassachusetts Institute of Technology2020

    Metabolic switch from oxidative phosphorylation (OxPhos) to glycolysis is a key feature of inflammatory response in macrophages, but how this switch occurs in response to inflammatory signals and how it precisely contributes to macrophage function is still obscure. Here we show that stimulation of …

    mit Repository record

  6. Integrated Analysis of Molecular and Clinical Features in Melanoma Patients with Brain Metastases

    Kumar, Swaminathan, <p>https://orcid.org/0000-0002-9358-787X</p>2026

    … by decreased oxidative phosphorylation (OXPHOS) and increased immune infiltration signatures compared to MBMs from patients with concurrent ECMs. To further characterize the role of OXPHOS in MBM progression, intra-patient variation in OXPHOS gene expression was studied using bulk RNA-seq …

    uthsc Repository record

  7. Significance of DNA base excision repair in the maintenance of mitochondrial function in Saccharomyces cerevisiae /

    Fang, Fang.Brock University2008

    … of ATP production via oxidative phosphorylation (OXPHOS). Accumulation of mtDNA mutations have been linked to the development of respiratory dysfunction, apoptosis, and aging. Base excision repair (BER) is the major and the only certain repair pathway existing in mitochondria that is in …

    brock Repository record

  8. INTERPLAY BETWEEN MDM2 AND TFAM REGULATES OXIDATIVE PHOSPHORYLATION IN DRUG-RESISTANT ONCOGENE-ADDICTED CANCERS

    EU JIE QING2022

    … of resistance. There is mounting evidence of OXPHOS dependency as a mechanism of TKI resistance, but the cause of this metabolic switch remains elusive. Here, we report a novel mechanism involving mitochondria-bound MDM2 (mtMDM2) in driving OXPHOS regulation in TKI-resistant cancers through an …

    nus Repository record

  9. Pyrimidine nucleotide carrier 1 in mitochondrial homeostasis and cancer

    Coleman, MichaelUniversity College Cork2017

    … cells, and restore oxidative phosphorylation (OXPHOS) activity to these cells. These data suggest that the mitochondrial dysfunction present in these cells is partially due to their low PNC1 expression. Conversely, we observed that suppression of PNC1 in MCF-7 cells suppresses OXPHOS. …

    cork Repository record

  10. Effects of Trimethylamine N-Oxide on Mouse Embryonic Stem Cell Properties

    Barron, Catherine MaryVirginia Tech2020

    … upon inhibition of oxidative phosphorylation (OxPHOS). It also significantly increased the rate of OxPHOS, maximal respiratory capacity, and respiratory reserve. These findings indicate that TMAO induced a metabolic switch of mESCs from high glycolytic activity to greater OxPHOS activity to …

    vt Repository record

  11. Energy metabolism in Arbidopsis thaliana: TCA cycle evolution, amino acids degradation and alternative pathways

    Cavalcanti, João Henrique FrotaUniversidade Federal de Viçosa2015

    … of the mitochondrial oxidative phosphorylation (OXPHOS) system and its alternatives pathways under energy limitation remains elusive. Thus, this thesis, which is focused on the function of respiration within the context of the role of the TCA cycle as well as the function of alternative electron …

    brazil-ufv Repository record

  12. Identification and Characterization of Mitochondrial DNA Variants in Alzheimer's Disease

    Hamblet, Natasha Singh2019

    … establish altered oxidative phosphorylation (OXPHOS) and ATP synthesis in AD tissue. ATP demand is most prevalent in the brain; damage to OXPHOS could severely impair brain metabolism, thereby leading to a decline in cognitive function. Four out of five complexes in the OXPHOS pathway are …

    odu Repository record

  13. An investigation into the novel effects of melatonin treatment on differentiated C2C12 myotubes in the absence and presence of pathology

    Wentley, Garth NicholasStellenbosch : Stellenbosch University2026

    … attenuates mitochondrial oxygen consumption and OXPHOS in myotubes by limiting oxygen wastage via an oxygen-sparing action. Moreover, in the pre and curative setting, MEL upregulated mitochondrial fusion. General Methods: For papers 1-3, we have employed an in vitro approach, where differentiated …

    stellenbosch Repository record

  14. Investigating how mitophagy is regulated by the metabolic context

    Montava Garriga, LambertUniversity of Dundee2020

    … dependencies between either a glycolytic or OXPHOS metabolic status. I implemented this metabolic modulation to address the aim in this thesis of identifying new factors regulating mitophagy by the metabolic context, which may provide new insights on the regulation of basal mitophagy in vivo. …

    dundee Repository record

  15. Investigating Cell-Type-Specific Vulnerability in Mitochondrial Disease Using Stem Cell-Derived Neuronal Models

    Zarate Mendez, MarianaUniversity of Cambridge2025

    … observed in patient-derived cells, including OXPHOS deficiency and mtDNA depletion, while revealing distinct adaptive and pathological responses between neuronal subtypes. MTRFR loss triggered cell-type-specific stress responses. Cortical neurons activated compensatory mechanisms such as …

    cambridge Repository record

  16. LINEAGE TRACING REVEALS PAEP AS A CHEMOTHERAPY-INDUCED METASTATIC DRIVER AND EXPOSES METABOLIC VULNERABILITIES OF CIRCULATING TUMOR CELLS IN BREAST CANCER

    DALMASSO, ALBERTOUniversità degli Studi di Milano2025

    … phenotype: single‐cell RNA‐seq showed strong OXPHOS enrichment, yet targeted metabolomics revealed global nutrient depletion, high NADPH utilization, and glutathione turnover, consistent with severe oxidative stress. Seahorse assays demonstrated suppressed respiration in CTCs relative to lung …

    milano Repository record

  17. Fbxw7 Triggers Degradation Of Kmt2d To Favor Growth Of Mature B-Type Malignant Cells

    Saffie, Rizwan2020

    … and genes related to oxidative phosphorylation (OXPHOS) in diffuse large B-cell lymphoma (DLBCL) and multiple myeloma (MM) cells. Consistently, loss of FBXW7 inhibits DLBCL cell growth and further sensitizes these cells to OXPHOS inhibition. Our findings elucidate a novel mechanism of regulation …

    penn Repository record

  18. Genetic Engineering as a Tool to Investigate Mitochondrial Gene Expression

    Mutti, ChristianUniversity of Cambridge2023

    … energy through the oxidative phosphorylation (OXPHOS) machinery. In mammals, mitochondria contain their own genome that encodes thirteen essential polypeptides for the OXPHOS system, alongside mitochondrial rRNAs and tRNAs required for their expression. Gene expression in mitochondria is …

    cambridge Repository record

  19. Investigating the anti-leukaemic effect of tamoxifen in the myeloproliferative neoplasms

    Fang, ZijianUniversity of Cambridge2023

    … subjects showed a high baseline expression of OXPHOS-related genes and their specific reduction after 24-week tamoxifen treatment in tamoxifen responders, compared with non-responders, suggesting that tamoxifen exerts a metabolic inhibition on OXPHOS in responder HSPCs. The suppression of …

    cambridge Repository record

  20. THE DEVELOPMENT OF SELECTIVE PHOTOSENSITIZERS TO TARGET PATHOGENIC T CELLS AND PREVENT GRAFT-VERSUS-HOST DISEASE

    McIver, ZachariahWake Forest University2017

    … the ability to target oxidative phosphorylation (OXPHOS) in pathogenic and malignant T cells. The photosensitizers are also potent stimulators of P-glycoprotein (P-gp). Enhanced P-gp activity promotes the efficient removal of photosensitizer not sequestered in mitochondria, and protects resting …

    wfu Repository record

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