Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"OX40"”.
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Cd4 T Cell Activation And Ox40 Agonist Immunotherapy In Tuberculosis
… expressed co-stimulatory genes including Tnfrsf4/OX40 and were functionally more protective than Nur77-GFPLO. Nur77-GFPLO cells more often expressed markers of terminal exhaustion, cytotoxicity, and the trafficking receptor S1pr5, associated with vascular localization. A short course of …
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Characterizing The Effect of Dasatinib On Anti-Tumor Immune Response and Exploring The Potential of Combining Targeted Therapy and Immunotherapy In A C-Kit Mutant Mastocytoma Model
… and IL-10. When dasatinib was combined with anti-OX40, an agonistic antibody that provides T cells with a potent costimulatory signal, we found that the two agents together gave a much better therapeutic effect compared with either therapy alone, leading to complete tumor eradication in most of …
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A HIF-INDEPENDENT PROGRAM SUSTAINS TUMOR TREG FUNCTION IN OXYGEN-DEPRIVED ENVIRONMENTS
… bioenergetics. Similarly, flow cytometry showed OX40 and CTLA4 upregulation at protein level in 3% O2, reverted to baseline by RBPJ inhibition. Suppression assay showed Treg suppressive function was accordingly dependent upon RBPJ activity in 3% O2. We validated our findings in tumor explants, a …
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Factors influencing the development of protective and pathological responses to Trichinella spiralis infection
… demonstrated that co-stimulation via ICOS and OX40 can modulate the development of Th2 responses and the development of T. spiralis induced enteropathy and mastocytosis. The failure of TNFα/LTα -/- mice to expel T. spiralis from the small intestine despite developing a more severe enteropathy, …
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A mouse model for the pathogenesis of immunodeficiency virus infection
… CCR5, the co-receptor for HIV and SIV, or CD134 (OX40, TNFRSF4), the cellular receptor for FIV. Activated CD4+ T cells were depleted by conditional reactivation of diphtheria toxin gene mediated by Tnfrsf4-driven Cre recombinase expression. Conditional ablation of activated CD4+ T cells resulted …
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Combination of Oncolytic Adenoviruses, T-Cell Activation, and Blockade of Ido Metabolic Circuitry For The Treatment of Glioma
… be enhanced by adding immune agonists, namely OX40L, which engages the OX40 receptor to co-stimulate activated T cells for enhanced proliferation. Hence, we produced the next generation of Delta-24-RGD, called Delta-24-RGDOX, which expresses OX40L. Our previous publications exhibited enhanced …
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Signals for B cell activation in antibody response
… as IL-6, IL-10, IL-21, costimulatory signals OX40, CD30 deficient mice show that these signals can affect the development of these early IRF4\(^+\) plasmablasts on the GC-T zone interface in the TD antigen response.