Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"OVA peptide"”.
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Staphylococcal Enterotoxin B Induced Clonal Anergy in αβ T Cell Receptor Transgenic Mice
… cells to a superantigen was followed by priming ovalbumin (OVA) specific αβ T cell receptor transgenic mice with SEB. Cells from these mice appeared to be anergic in that they were hyporesponsive to OVA peptide as well as to SEB. The anergic cells could respond to PMA and ionomycin suggesting …
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Development of a hydrogel-based microfluidic model of the lymph node
… an antigen specific immune response to an OVA peptide. In the final part of the thesis, I modelled a TDLN in vitro. The LN device was incubated with tumour conditioned media (TCM) and IL-7 downregulation was observed, similarly to in vivo murine melanoma models. Then, to increase the …
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Modulation of dendritic cells by human neutrophil elastase and its inhibitors in pulmonary inflammation
… DCs were less efficient at presenting ovalbumin (OVA) peptide to naïve OVAspecific transgenic (D011.10) T cells. In addition, immature DCs (iDC) simultaneously treated with LPS and NE failed to mature fully and produced significantly less IL-12 and TNF-α than DCs matured in the presence …
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Anti-Nucleic Acid Antibody-Mediated Cross Presentation of An Antigen and Its CD8+ T Cell Activation
… 3D8. As the CD8-T cell epitopes, chicken ovalbumin amino acid 257-264 (OVA257-264-SIINFEKL) and 250-264 (OVA250-264-SGLEQLESIINFEKL) were used for 3D8 scFv fusion partners. Purified 3D8 scFv-OVA fusion proteins with ~95% purity retained DNA-binding, DNA-hydrolyzing, cell-penetrating, and …