Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"OTX2"”.
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Patterning the Xenopus neurectoderm : the role of otx2 in the determination of cement gland and anterior neural fates
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
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Effects of the OTX2ECR2 enhancer & PROX1 overexpression in murine retina development
… retinal progenitor cells that upregulate the <em>OTX2</em> gene in the developing retina of the mouse. OTX2 is a homeobox transcription factor important for the development of photoreceptors and bipolar cells. If OTX2 is knocked out, photoreceptors and bipolar cells fail to differentiate. In order …
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Understanding Genomes Through Engineered Structural Variation
… loxPsym sites into the regulatory region of the *OTX2* developmental transcription factor. Cre recombinase induced stochastic deletions and inversions across the recombinase sites, and created diverse and novel enhancer arrangements. By endogenously fusing *OTX2* with a fluorophore and sorting, I …
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Genesis of the human germline
… germ cell competence. I found the inhibition of OTX2 increased the efficiency of human PGCLC specification, which is consistent with a transient reduction in OTX2 in the germline competent PreME against rising levels of EOMES. The OTX2 levels continue to increase in ME cells that gain competence …
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Optimizing CRISPR/Cas9 Gene Targeting to Investigate Cone Photoreceptor Development in the Chick Retina
… mutagenesis of two key transcription factors, Otx2 and Nr2e3, on retinal progenitor cells and cone photoreceptors throughout the development of the retina. This study also explores optimization of the CRISPR/Cas9 system to target specific cell populations.</p>
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Integrin signalling in pluripotent cells acts as a gatekeeper of mouse germline entry
… of the PGC transcriptional repressor, Otx2, during a critical window of competence. Therefore, integrin signalling restricts mouse germline entry, pointing to a mechanism through which the loss of basement membrane contact by epiblast cells *in vivo* acts as a morphogenetic fate switch …
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Role of Xenopus Pitx3 during early development.
… expression of Pax6, Six3, Rx, betaB1-crystallin, Otx2, and Lens1. Similar effects are obtained using antisense morpholino oligonucleotide-mediated translation knockdown. Reciprocal grafting experiments using wildtype and morpholino treated tissues demonstrate that xPitx3 in the presumptive lens …
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Temporal and spatial controls of cell fate specification in the cerebellum
… of early genetic regional determinants (Otx2), I demonstrate that this expanded region of Atoh1 is dependent upon the isthmus for its induction and maintenance. I also demonstrate the role of the isthmic gene, Fgf8, in the maintenance of the expanded domain through in ovo electroporation …
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Funktionsanalyse des Irx1-Gens
… bedeutsamer Gene wie BMP4, Brachyury, Gbx2 oder Otx2 gezeigt werden. Sie sind die genetischen Marker für das extraembryonale Mesoderm, den Primitivstreifen oder das anteriore viszerale Endoderm. Anhand dieser Daten konnte gezeigt werden, daß Irx1 eine essentielle Rolle während der Gastrulation …
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Valproic Acid-Induced Teratogenesis in Japanese Rice Fish (Oryzias Latipes) Embryogenesis
… the genes involved with neurogenesis (wnt1, otx2 and nlgn3b) and regulation of cell division (shh and ccna2) shodevelopmental stage-specific alteration after valproate exposure. This study indicates that valproate is able to induce some phenotypic features in Japanese rice fish which are …
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Developing a stem-cell system of embryonic development organised by a morphogen signaling centre
… as seen by an upregulation in POU3F1, EN1, OTX2, IRX6, and SCUBE1. Interestingly, gastruloids cultured in polyethylene glycol-acrylate-sulfhydryl hydrogels had no change in morphology. Confocal imaging confirmed the localization of brachyury, a primitive streak marker in some gastruloids. …
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The role of notch signaling in the development of the hypothalamic-pituitary axis and arcuate nucleus
… crucial to pituitary development, such as OTX2 and Fgf10, coincident with reduced survival of pituitary progenitors. Taken together, our results indicate that Rbpjκ- dependent Notch signaling within the developing hypothalamus is not necessary for pituitary development, but persistent Notch …