Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"OTUB1"”.
-
The regulation of TGFβ/BMP signalling by deubiquitylating enzymes
… (DUBs). A proteomic screen identified the DUBs OTUB1 and USP15 as potential novel regulators of the TGFß and BMP pathways respectively.<br/>Endogenous OTUB1 was recruited to the active phospho-SMAD2/3 complex only upon TGFß induction and OTUB1 had a crucial role in TGFß-mediated gene …
-
Detection and measurements of free ubiquitin in fixed cells and characterization of OTUB1 contribution to ubiquitin homeostasis
… of Ub homeostasis in vivo. The role of OTUB1 in Ub homeostasis has been hypothesized because its catalytic activity is affected by the ratio of [Ub~E2] to [E2] in response to free Ub concentration. Interaction between OTUB1 and a subset of E2s can stimulate OTUB1 isopeptidase activity, …
-
Characterising Novel Substrates of the Asparaginyl Hydroxylase FIH
… FIH. The final aim of this thesis was to analyse OTUB1, a non-ANK and non-HIF protein discovered by our collaborators as a putative novel substrate of FIH. The hydroxylation of OTUB1 on N22 by FIH in vitro was confirmed using synthetic OTUB1 peptides in CO₂ capture assays.