Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"OSMR"”.
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Relevanz der Transmembran- und Intrazellulärregion von gp130, LIFR und OSMR für deren Liganden-induzierte Signaltransduktion
… to transmit signals into cells: gp130, LIFR and OSMR. Here it could be demonstrated that the signal transducing capacities of LIFR and gp130 are highly redundant. The box1/2 region of the LIFR recruits the Janus kinases Jak1, Jak2 and Tyk2; the membrane distal tyrosine residues are sufficient for …
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Oncostatin M Receptor Overexpression Promotes Tumour Progression in Squamous Cell Carcinoma, via Hypoxia Signalling and Multiple Effects on the Tumour Microenvironment
… 5p. In this region, copy number gain of the OSMR gene was found to correlate significantly with adverse outcome independent of the tumour stage (p=0.046). Furthermore, this copy number gain correlated with Oncostatin M receptor (OSMR) overexpression and sensitised these cells to Oncostatin M …
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Effects of Oncostatin-M Receptor overexpression on cervical squamous cell carcinoma cells and their extracellular vesicles
… novel therapies. The oncostatin-M receptor (OSMR) frequently undergoes copy-number gain and overexpression in squamous cell carcinomas (SCC) at multiple sites, consistently associated with an adverse overall survival independent of tumour stage. OSM-OSMR signalling activates STAT3 and …
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Die Regulation der Expression des humanen Oncostatin-M-Rezeptors durch Januskinasen
The oncostatin M receptor (OSMR) is part of a heterodimeric receptor complex which mediates signal transduction of the pleiotropic cytokine OSM. Like other cytokine receptors, the OSMR does not contain intrinsic kinase activity and therefore signalling events are mediated by members of the family …
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Charakterisierung der Oncostatin-M-vermittelten STAT5-Aktivierung : Beitrag des Rezeptorkomplexes und der Januskinasen
… complex containing the subunits gp130 and OSMR. This leads to activation of the JAK/STAT pathway. Our study shows that OSM is characterized by a strong activation of STAT5 in different cell lines; this is not the case for IL-6 or LIF. Recruitment of STAT5 is mediated by the specific OSMR …
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Bedeutung der Lipopolysaccharidstrukturen bei pathogenen Vibrio cholerae Stämmen für die Ausbildung von Cholera und Abgrenzung zu Umweltisolaten
… VCA0565 das putative Zwei-Komponentensystem OsmRK dar. Transkriptomanalysen von osmR/ K-Mutanten lieferten keine Erklärung des Wachstumsdefekts unter hypertonischen Bedingungen, zeigten aber eine Vernetzung der durch OsmR/ K regulierten Gene mit dem ToxR-Regulon auf. Analysen der Außenmembran …
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Bedeutung von Interleukin-6, Oncostatin M und Interleukin-31 für die biochemische und immunologische Barrierefunktion der Haut
… Despite the expression of the OSM receptor (OSMR) we could not observe an increased expression of MRP-3 in keratinocytes while MRP-1 mRNA levels were elevated. On the other hand OSM turned out to be a more effective stimulator of MRP synthesis in dermal fibroblasts. Both cytokines induced a …
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Negative Regulation der Oncostatin M-vermittelten Signaltransduktion
… the role of the specific Oncostatin M receptor (OSMR) in the SOCS3 mediated inhibition of the OSM pathway is analyzed. The obtained results point to a new mechanism of the inhibitory action of SOCS3. We could show that OSM induces the expression of SOCS3 much more efficiently than IL-6 due to a …
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Cytokine resistance in melanoma
… Although the relevant receptors gp130 and OSMR are expressed at the cell surface of these cells, cytokine stimulation hardly led to activation of Jak1, STAT3 and STAT1. I found a high level constitutive expression of SOCS3 that did not further increase after cytokine treatment. Importantly, …