Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"OSCC"”.
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Perineural Invasion in Oral Squamous Cell Carcinoma and Salivary Gland Malignancies: Incidence, Prognostic Impact and Molecular Insight
… invasion (PNI) in oral squamous cell carcinoma (OSCC) and salivary gland malignancies (SGMs) worldwide. PNI exhibited by some OSCC and SGMs has been known as an independent predictor of poor prognosis and an indicator of aggressive behaviour. Furthermore, the literature suggests a possible …
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Analysis of driver gene mutations in oesophageal squamous cell carcinoma
… (OAC) and oesophageal squamous cell carcinoma (OSCC). OAC is more common in North America and Europe, while OSCC predominantly occurs in Eastern Asia, Sub-Saharan Africa and Latin America. Over 80% of the OSCC cases and deaths worldwide occur in less developed regions, including Sub-Saharan …
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Proliferative and survival pathways in oesophageal cancer
Oesophageal squamous cell carcinoma (OSCC) is the 8th most common cancer worldwide with high incidence in areas that include China, Iran and South Africa. The current treatment available for OSCC does not significantly enhance patient survival. A better understanding of proliferative and survival …
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Functional analysis of N-MYC downstream regulated gene 1 (NDRG1) in Oesophageal squamous cell carcinoma
Oesophageal squamous cell carcinoma (OSCC) ranks as one of the deadliest tumours with a high incidence in developing countries in the areas of Southern Africa, Middle East and Far East. Moreover, its unfavourable prognosis is further complicated by the lack of knowledge about the molecular biology …
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EVALUATING THE CHEMOTHERAPEUTIC EFFECTS OF SR9009 AND ESOMEPRAZOLE ON ORAL SQUAMOUS CELL CARCINOMA USING CIRCADIAN-TAILORED INNOVATIVE THERAPEUTIC APPROACHES
… rate of 66%, is oral squamous cell carcinoma (OSCC). New potential triggers, including circadian clock disruption that is caused by multiple lifestyle traits such as chronic gastroesophageal reflux and human papillomavirus (HPV) infection are emerging new causal factors that might be …
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Role of extracellular vesicles from periodontopathogens in serum resistance and oral cancer
Oral squamous cell carcinoma (OSCC) is the most common cancer encountered in the head and neck area. Oral dysbiosis and periodontopathogens induce periodontitis, an inflammatory disease of the teeth-supporting tissues. Recent evidence supports that the oral microbiota and dysbiosis are linked to …
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The role of human papillomavirus (HPV) E6 proteins as a risk factor for oesophageal cancer
Oesophageal squamous cell carcinoma (OSCC) is a major cancer in South Africa, affecting mainly black males. Several risk factors for OSCC have been reported but this study focuses on the role of human papilloma virus (HPV) in the development of OSCC. HPV is a well-known risk factor for cervical …
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Enhancing Early Detection of Oesophageal Squamous Cell Carcinoma Through Shallow Whole-Genome Sequencing and Non-Endoscopic Sponge Sampling
… of oesophageal squamous cell carcinoma (OSCC) remains high, accounting for approximately 90% of the nearly half-million annual cases of oesophageal cancer globally. Although effective, conventional upper endoscopy is invasive and costly, limiting its widespread use for screening high-risk …
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Investigating the Role of Cigarette Smoke and Alcohol in Oesophageal Squamous Cell Carcinoma
… problem. Oesophageal Squamous Cell Carcinoma (OSCC) is the more common subtype of and accounts for about 90% of incident oesophageal cancers every year (Abnet et al., 2018) with the majority of OSCC cases occur in developing countries. The objective of this study was to investigate cigarette …
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Identification of genetic polymorphisms associated with oesophageal squamous cell carcinoma risk in South Africa
Oesophageal squamous cell carcinoma (OSCC) is a complex disease, determined by the interaction of genetic factors with environmental risk factors. In South Africa, OSCC is a major malignancy occurring with high incidence in the Black and Mixed Ancestry populations. Previous studies by our research …
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Oesophageal squamous cell carcinogenesis : a study of cell cycle regulatory proteins by immunohistochemistry
Oesophageal squamous cell carcinoma (OSCC) is a highly malignant tumour that has a poor prognosis and shows marked regional variation in its incidence, implicating environmental factors. South Africa is one of several countries that has areas of high incidence. The exact aetiopathogenesis of OSCC …
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The analysis of genetic aberrations in South African oesophageal squamous cell carcinoma patients
… cancer. Oesophageal squamous cell carcinoma (OSCC) occurs in the upper to mid oesophagus and is present at high incidence in developing countries including South Africa. There are no early symptoms, resulting in late diagnosis and poor prognosis. In this study, tumour and blood DNA was …
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The Role of the Aryl Hydrocarbon Receptor in Tumor Growth and Chemoresistance
… progression in oral squamous cell carcinomas (OSCC), and other cancers. The AHR is activated by environmental toxins, including polycyclic aromatic hydrocarbons, which are commonly found in cigarette smoke. It is hypothesized that activation of the AHR by these environmental toxins can …
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The expression and role of Migration Stimulating Factor (MSF) in oral tumours
… value of MSF in oral squamous cell carcinoma (OSCC; chapter 4), and salivary gland tumours (SGT; chapter 5).<br/>• To identify the putative MSF receptors in oral tumour cell lines (chapter 6).<br/><br/>For tissue culture studies, the effects of rhMSF (wild type and mutant proteins) were …
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Mecanosensibilidad mediada por PIEZO2
… En los órganos sensitivos cutáneos complejos (OSCC), en la periferia de los mecanorreceptores de bajo umbral (MRBU), se originan los estímulos nerviosos mecánicos en virtud de un proceso denominado mecanotransducción, que consiste en la conversión de estímulos mecánicos en señales eléctricas; …
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PARP inhibition in combination with radiation therapy for the treatment of feline oral squamous cell carcinoma
Feline oral squamous cell carcinoma (FOSCC) is a devastating tumor frequently palliated with radiation therapy (RT). Disappointingly, RT typically exerts marginal and transient tumor regression and new strategies to enhance RT efficacy are needed. Poly (ADP-ribose) polymerase (PARP) is a key …
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Development of Electrochemical Immunosensor for Oral Cancer: Initial Outcome
Oral Squamous Cell Carcinoma (OSCC), accounting for nearly 90% of head and neck malignancies, continues to pose a global health challenge with over 250,000 new cases annually, especially in developing nations. Its frequent progression from precancerous lesions such as oral leukoplakia (OL) …
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Expression and regulation of N-Myc Downstream- Regulated gene 1 in squamous cell carcinoma of the oesphagus
… (NDRG1) in oesophageal squamous cell carcinoma (OSCC) tissue compared to normal tissue in a cohort of South African cancer patients. Despite more than ten years of research into the role of NDRG1 in cancer, the precise function of this protein remains enigmatic. Reports have been contentious, …
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Innovating surgery for oral squamous cell carcinoma with targeted fluorescent and magnetic tracers
Oral squamous cell carcinoma (OSCC) is characterised by its locally aggressive nature and its high propensity to metastasise to regional lymph nodes (LN)s. It is well-established that margin status and the presence of LN metastases are two of the most important factors affecting prognosis. While …
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Investigation into the effects of the tobacco smoke procarcinogen benzo[a]pyrene on gene expression profiles in oesophageal cancer
… of oesophageal squamous cell carcinoma (OSCC). Benzo[a]pyrene (BaP) is a tobacco smoke procarcinogen that is metabolically activated into the carcinogenic benzo[a]pyrene diol-epoxide (BPDE) by the CYP1 family of cytochrome P450 enzymes. BaP is a ligand for the aryl hydrocarbon receptor …
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