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Showing 1 to 1 of 1 for “"ORTHOTOPIC MICE"”.
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Functional contribution of epithelial to mesenchymal transition program on KRASG12D targeting efficacy in pancreatic cancer
… (TF) <em>Zeb1</em> (Zeb1<sup>cKO</sup>) and orthotopic models with conditional deletion of the EMT TFs <em>Snail</em> and <em>Twist</em> (ST<sup>cKO</sup>) to evaluate the role of EMT transcription factors in the efficacy of MRTX1133. We further probed the efficacy of Kras inhibition and …