Global ETD Search
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Showing 1 to 1 of 1 for “"ORP5"”.
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Targeting Plasma Membrane Phosphatidylserine Content to Inhibit Oncogenic Kras Function
… oncogenesis. Oxysterol-related binding proteins ORP5 and ORP8 exchange PtdSer synthesized in the ER for phosphatidylinositol-4-phosphate (PI4P) synthesized in the PM. We show that depletion of ORP5 or ORP8 reduced PM PtdSer levels, resulting in extensive mislocalization of KRAS from the PM. …