Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"ORCA/LRWD1"”.
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Role of ORCA/LRWD1 in the maintenance of telomere integrity
… how Origin Recognition Complex-associated (ORCA/LRWD1), regulates telomere integrity in Alternative Lengthening of Telomeres (ALT) -positive cells. In the absence of Telomere Maintenance Mechanism (TMM), the end replication problem will lead to the loss of telomere length through each round …
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ORCA/LRWD1, a novel player in the initiation of eukaryotic DNA replication
… and WD40 repeat domain-containing protein 1 (LRWD1) or ORC-associated (ORCA). It interacts with ORC and modulates its chromatin association. ORCA co-localizes with ORC, shows similar cell cycle dynamics, and efficiently recruits ORC to chromatin. Depletion of ORCA in human primary cells and …
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Role of ORCA and ORC in chromatin organization and DNA replication
… protein Origin Recognition Complex-Associated (ORCA/LRWD1), preferentially localizes to heterochromatic regions in post-replicated cells. The role of ORCA and ORC in heterochromatin organization remained elusive. In Chapter II, I describe my efforts to understand the significance of ORCA-ORC’s …