Global ETD Search
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Showing 1 to 3 of 3 for “"ORB2"”.
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Role of Drosophila Orb2 (CPEB) in Synaptic Protein Synthesis
… is to determine how Drosophila neuronal CPEB, Orb2, regulates protein synthesis and how conversion to the aggregated state effects its function. Combining in vitro and in vivo studies we find that the monomeric Orb2 represses, while the amyloidogenic oligomeric Orb2 enhances translation and …
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Drosophila CPEB, Orb2, a Putative Biochemical Engram of Long-term Memory
… aggregation of the RNA-binding protein CPEB/Orb2 is one of the candidate mechanisms of memory maintenance. Here, using tools that allow rapid and reversible inactivation of Orb2 protein I find that Orb2 activity is required for encoding and recall of memory. Blocking the Orb2 oligomerization …
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The Role of the ORB2 RNA-binding Protein in Post-transcriptional Regulation
… the study of these mechanisms. In Drosophila, ORB2 is an RBP expressed in the early embryo. It has been shown to regulate translation of bound mRNAs, but relatively little is known about what RNAs it targets in early embryogenesis and the mechanisms by which it confers this regulation. In this …