Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"OPRM1"”.
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Exploring the role of mu opioid receptor (OPRM1) and CYP2B6 gene variations for methadone pharmacogenomics. Can these variations be used to advance toxicological interpretation post-mortem?.
… toxicity and CYP2B6 and mu (μ) opioid receptor (OPRM1) single nucleotide polymorphisms (SNPs). Using SNP genotyping, the association between OPRM1 A118G and CYP2B6 T750C, G516T, and A785G variations and post-mortem methadone concentrations were investigated. The allele frequencies of OPRM1 and …
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The biological bases of social deficits: the roles of social motivation, theory of mind, and selected genotypes (OPRM1, 5-HTTLPR) in autism spectrum disorder
… theories, namely the mu-opioid receptor gene (OPRM1) and the serotonin transporter promoter length polymorphism (5-HTTLPR) respectively. For the first study of this protocol, I assessed the possible relationships between social motivation, OPRM1, and the ASD phenotype. For the second study, I …
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Transcriptional regulation of human mu-opioid receptor gene: functional characterization of activating and inhibitory transcription factors
… al., 2003). The human mu-opioid receptor gene (OPRM1) promoter is of the TATA-less type and has clusters of potential binding sites for different transcription factors (Law et al. 2004). Several studies, primarily focused on the upstream region of the OPRM1 promoter, have investigated …
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The Relationship between methylation and genes associated with opioid response in humans.
… region methylation of ABCB1/MDR1, CYP2D6 and OPRM1 genes were analysed by pyrosequencing in smoking, opioid exposed and control pilot populations. Genetic variations within ABCB1/MDR1, COMT, CYP2B6, CYP2D6 and OPRM1 genes were also investigated. Tissue opioid concentrations were determined by …
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The relationship between genes associated with the pain pathways and the development of chronic shoulder pain and disability in South African breast cancer survivors
… rs1128503 G>A), (II) Opioid Receptor, Mu 1 Gene (OPRM1); (rs1799971 A>G; rs540825 T>A) and (III) Catechol-O-Methyl Transferase Gene (COMT); (rs6269 A>G; rs4633 C>T; rs4818 C>G; rs4680 G>A) and the prevalence of chronic pain and disability. iii. Evaluate the gene-gene interaction and association …
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The effect of genotype on attention bias in rhesus macaques, Macaca mulatta, as a welfare indicator.
… 6- and 7-repeat allele) and mu-opioid receptor (OPRM1; C and G allele). Additionally, sequencing was utilised to identify novel SNPs in the dopamine receptor D4 (DRD4). The 5-HTTLPR short-, TPH2 long-, MAOA 7-repeat and OPRM1 G-allele are low-expressing alleles leading to lower levels of …
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Quantitative Genexpressionsanalyse im respiratorischen Netzwerk an Mausmodellen für das Rett-Syndrom
… und als Aktivator auf Grin2d (P7), Drd4 (P7), Oprm1 (P40) wirken könnte. Sehr starke Evidenzen weisen daraufhin, dass Htr5b und Foxp2 ebenfalls Zielgene von MeCP2 sind und dass MeCP2 supprimierend auf deren Expression wirkt. Um die Zusammenhänge zwischen MeCP2 und seinen Zielgenen und damit …
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Genetic factors associated with neuropathic pain
… with NP, and that SNPs in neither COMT nor OPRM1 were associated with NP. he GWAS using dispensed medication records identified a novel genome-wide significant NP susceptibility locus near PRL, and replicated this in UKBB. The largest meta-analysis of the discovery GWAS of NP using …
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Effetto dell’esposizione cronica volontaria di eroina e WIN55,212-2 sull’espressione di micro RNA nelle aree cerebrali coinvolte nella dipendenza da sostanze d’abuso
… NOS1, FC=11.05; MECP2, FC=11.03; SIRT1, FC=6.30; OPRM1, FC=3.89) and 1 downregulated (BDNF, FC=-2.23). We identified only 1 gene downregulated in the prefrontal cortex (BDNF, FC=-2.15). No changes were observed in NAc shell. Protein expression analysis revealed that the levels of BDNF, MeCP2 and …
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Pharmacogenomics of sickle cell disease therapeutics: pain and drug metabolism associated gene variants and hydroxyurea-induced post-transcriptional expression of miRNAs
… P = 0·027; FAAHrs4141964, P = 0·003; OPRM1- rs1799971, P = 0·031; ADRB2-rs1042713; P < 0·001; UGT2B7-rs7438135, P = 0·037). The 3·7 kb HBA1/HBA2 deletion correlated with increased VOC (P = 0·002). HbF-promoting loci variants correlated with decreased hospitalisation (BCL11A-rs4671393, …