Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"OPLS-DA"”.
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Metabolomic modelling and applications in inflammatory bowel diseases
… experiments typically produce high dimensional data and its handling is an extremely important step in data pre-treatment. Metabolomics is an indispensable research tool for the identification and tracking of biomarkers in biological systems. In a typical metabolomics study, complex extracts or …
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Exploring recent innovations in ambient mass spectrometry to deliver a paradigm shift in food safety, security and authenticity
… analysis (PCA), linear discriminant analysis (LDA) and orthogonal partial least squares-discriminant analysis (OPLS-DA) chemometric models were built which demonstrated clear differences between some of the different production systems, most notably allowing those using different breeds of bird …
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Metabolic profiling of cyanobacterial extracts using multivariate data analysis for their anti-obesity properties
… aim of this study was to perform multivariate data analysis (MVDA) on 117 cyanobacterial extracts to identify potential biomarkers with anti-obesity properties. Methods. Obtained data from UPLC-QTOF-MS was preprocessed by MarkerLynx software to optimize the data evaluation. MVDA was performed …
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The use of metabolomics tools to assess the therapeutic natural products of honey and propolis from Malaysia and New Zealand
… is mainly composed of plant resins and exudates that bees gather. Many studies demonstrated anti-inflammatory, anti-bacterial, anti-oxidant and anti-proliferative properties of honey and propolis extract.;However the chemical profiling of Malaysian honey and propolis has not been well …
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The use of hair detect (and monitor) chronic hyperglycaemia
… to Latent Structures Discriminant Analysis (OPLS-DA) models between spectra obtained from hair of diabetic participants and spectraobtained from control hair show good separation and predictive ability. When ATR-FTIR spectra were analysed in four groups: children with natural hair, adults …
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Metabolomic comparison of selected Helichrysum species to predict their antiviral properties
… treatment of coughs, colds, fever, infection, headaches, menstrual pain and are very popular for wound dressing. Previous published research has shown that H. aureonitens has antiviral properties against Herpes simplex virus type 1 (HSV-1). In this study, further investigation into the Helichrysum …
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A metabolomics approach for targeted isolation and production of bioactive secondary metabolites in microbial isolates from extreme environments
Marine microorganisms produce unique secondary metabolites, which are responsible for a variety of biologically active molecules with a wide range of pharmaceutical properties. There is a lack of novel effective drugs for metabolic diseases, cancer and parasite infections as well as TNF-alpha …
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The Use of Hair Cortisol as a Biomarker of Chronic Stress in Patients with a recent Acute Myocardial Infarction
… is painless, provides a longer detection window (days to months depending on length) and is easy to store. Recent studies confirm good correlation between hair cortisol levels and validated stress questionnaires (i.e., hair cortisol is a biomarker of stress). It is unclear whether stress is a …
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La Metabolomica: una nuova era in Cardiologia. Le nostre esperienze originali nei campi dell' insufficienza cardiaca, della cardiopatia ischemica e dell' ipertensione polmonare
… failure (HF) is characterized by a series of maladaptive metabolic changes, which have recently been proposed as a new therapeutic target. A proton nuclear magnetic resonance (1H NMR)-based MBS analysis was performed on blood samples of 3 groups of individuals: nine control individuals (Group A); …
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Microbial, metabolic and molecular determinants of neonatal mortality in the rural areas of Limpopo Province, South Africa: umblical cord blood metabolomic profile and bacterial anaysis and their association with perinatal complications
… consent, questionnaires were used for data collection and umbilical cord blood samples were collected from 129 participants. Blood culture was done, and antibiotic susceptibility testing was conducted on the isolates. Additionally, genomic DNA was isolated from the blood samples for the …
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The application of metabolomics in human health and disease
… due to its inherent higher sensitivity and fast data acquisition, MS remains one of the most dominant analytical techniques used in metabolomics. In this project, metabolomics was employed in various studies to assess metabolite biomarkers associated with health and disease. All the studies …
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Metabolomic investigation of food matrices by 1H NMR spectroscopy
The present Ph.D. work shows some applications on the NMR-based metabolomic approach in food science. The investigated food matrices are largely different, from a manufactured product that undergoes only physical treatments (bottarga), to a manufactured product where biochemical transformations …
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Is there an association between frontal fibrosing alopecia and sunscreen actives?
… Partial Least Squares Discriminant Analysis (OPLS-DA). Secondly, immortalized human keratinocytes (HaCaTs) as well as fibroblasts derived from FFA site specific biopsies (normal scalp, active edge and scarred area) from 4 FFA patients were exposed to 5 common sunscreen actives viz: titanium …
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The Therapeutic Potential of Natural Products from <i>Vaccinium</i> Berries for Viral and Lung Diseases Through an Improved LC-MS-Based Chemometric Approach
… death worldwide. Analysis of publicly available data revealed that smoking prevalence rates among the youth in developing countries, especially in Bulgaria, are alarmingly high. The Bulgarian population has one of the highest percentages of smokers and the second highest rate among teenage girls. …
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Phytochemical, biological and toxicity studies of terminalia sericea burch. (Combretaceae)
… safety and efficacy of the plant material. To date, there are no available data on parameters that can be used to standardise the quality of T. sericea raw materials. The aim of this study was therefore to provide information on the variation of the chemical constituents that contribute to the …
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Investigation of the effects of emerging technologies on the kinetics of glycolytic and proteolytic enzymes relevant for meat quality
… pyruvate kinase. Proteolysis involves the degradation of key structural muscle proteins such as desmin and titin, which contributes to the tenderisation of muscle. Enzymes involved in proteolysis include calpains and cathepsins. Carcass interventions offer the potential to modulate these …