Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"OPCs"”.
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Exploring the methylome and transcriptome of young adult and aged OPCs
… are the Oligodendrocyte Progenitor Cells (OPCs). Similar to other regenerative processes, remyelination efficiency declines with ageing. It is still unknown how much of this decline can be attributed to intrinsic changes in the OPCs themselves rather than environmental changes arising from …
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Investigation of mitigation and detection methods of Open Phase Conditions (OPCs) in nuclear power plants based on the operating experience
… dissertation is about Open Phase Conditions (OPCs), which occur when one or two of the three electrical phases are lost or open circuited, e.g. one circuit breaker phase doesn’t open or close. The study of this condition is important, as it can affect important-to-safety equipment, which is …
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Automated Identification and Tracking of Motile Oligodendrocyte Precursor Cells (OPCs) from Time-lapse 3D Microscopic Imaging Data of Cell Clusters in vivo
… migration of Oligodendrocyte precursor cells (OPCs) and its role in the central nervous system. However, current practice of image-based OPC motility analysis heavily relies on manual labeling and tracking on 2D max projection of the 3D data, which suffers from massive human labor, subjective …
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Oligodendrocyte precursor cell states and their regulation
Oligodendrocyte precursor cells (OPCs) differentiate into myelinating oligodendrocytes throughout life, allowing the formation of myelin during early development, but also following learning or demyelinating injuries. A number of factors are thought to regulate OPC proliferation and …
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Molecular interventions to overcome the ageing of CNS stem cells
Oligodendrocyte progenitor cells (OPCs) are the dominant tissue-specific stem cell of the central nervous system (CNS). In the adult, OPCs primarily differentiate into oligodendrocytes, the cell type that wraps neurons with myelin allowing for efficient signal transduction down the axon. …
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An improved method for generating oligodendrocyte progenitor cells from murine induced pluripotent stem cells
… iPS cell is an ideal source for derivation of OPCs, as it offers the advantage of autologous transplants, and a model to study the biology and pathology of OPCs and oligodendrocytes. Existing protocols for deriving OPCs from mouse iPS cells, although a valuable model, are inefficient and not …
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Rejuvenation of CNS Progenitors via Partial Reprogramming
… with age. Oligodendrocyte progenitor cells (OPCs) are the largest population of stem cells in the adult CNS and give rise to oligodendrocytes. OPCs play a critical role in myelin regeneration (remyelination), but, like all stem cells, their regenerative capacity declines with age. OPCs …
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Functional heterogeneity of oligodendrocyte progenitor cells in the central nervous system
… called oligodendrocyte progenitor cells (OPCs). Oligodendrocyte lineage cells (OLCs) have been implicated in the pathophysiology of various diseases including not only demyelinating diseases (eg. Multiple Sclerosis (MS) or Pelizaeus-Merzbacher disease (PMD)), but also psychiatric disorders …
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Role of the Neurotransmitter Glutamate in Neural Stem and Progenitor Cells Differentiation into Oligodendrocytes
… NSPCs into oligodendrocyte precursor cells (OPCs) using various driving factors (PDGFα and NT-3) and the neurotransmitter (NT) glutamate. Glutamate is one of the main NTs in the central nervous system (CNS) hence, it may have a role in the differentiation of NSPCs into OPCs. My results …
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Changes in the Oligodendrocyte Progenitor Cell Nuclear Lamina During Ageing
… the OPC microenvironment, with exposure of aged OPCs to mechanically softer microenvironments enhancing their regenerative properties. However, the mechanisms underlying this phenomenon remain unclear. The purpose of this thesis was to explore a possible role of the nuclear lamina (a …
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Imaging Myelin Basic Protein expression in a model of remyelination by Magnetic Resonance Imaging using an Organic Anion Transporter Protein gene reporter system.
… endogenous oligodendrocyte progenitor cells (OPCs) responsible for remyelination or 2) transplantation of myelinogenic cells (including OPCs). The first approach is appropriate for diseases with no defect in the myelinating cells, such as multiple sclerosis (MS), while the second approach is …
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Investigating neuroectodermal transdifferentiation: How do CNS progenitors form Schwann cells?
… progenitors, oligodendrocyte progenitor cells (OPCs), can produce SCs in vivo. The mechanisms underlying this damage-induced plasticity of OPC fate choice remain incompletely understood. Therefore, in this thesis I sought to understand how changes in the lesion environment alter the …
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Development of Nontargeted Screening Algorithms for Indoor Contaminants
… products of organophosphorus compounds (OPCs). By further expanding the R package to incorporate in silico MS2 fragmentation prediction, 40 OPCs were detected in 23 house dust samples among which 24 OPCs were predicted to be formed through indoor reactions (Chapter 4). To systematically …
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Oligodendrocytes of the adult hypothalamic median eminence
… Both immature oligodendrocyte precursor cells (OPCs) and mature myelinating oligodendrocytes (MOLs) are found in this region in adults. While proliferation of ME OPCs has been shown to be involved in bodyweight maintenance, not much is known about the functions of other subtypes of …
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Development and implementation of a microresonator impactor for atmospheric particulate sensing
… As a result, optical particle counters (OPCs) have risen in popularity given their ability to consistently size and count individual particles. OPCs have limitations, however, in their inability to detect ultrafine particles (considered the most influential to human health) or to measure …
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Regulation of oligodendrocyte lineage cell function by the RXR$\gamma$ nuclear receptor
… process are oligodendrocyte progenitor cells (OPCs), a widespread population of CNS progenitor cells which persist into adulthood. Remyelination is impaired in patients with chronic demyelinating conditions such as Multiple Sclerosis, and as with other regenerative processes, its efficiency …
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DISEASE-MODIFYING APPROACHES TO MULTIPLE SCLEROSIS: DESIGN AND SYNTHESIS OF NOVEL POTENTIAL THERAPEUTIC AGENTS
… of the Oligodendrocyte Progenitor Cells (OPCs) and plays a key role in remyelination. Thus, we focused on the modulation of the activity of GPR17. We planned new ligands by connecting the haptophoric fragments of potent derivatives, which are however endowed with intrinsic low specificity …
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Altering Inhibitory Extracellular Matrix Promotes Remyelination
… accomplished by oligodendrocyte precursor cells (OPCs) that proliferate, migrate, and differentiate into myelin-forming oligodendrocytes. A number of lesion-associated factors have been identified that interfere with the remyelination response. Chondroitin sulfate proteoglycans (CSPGs) are a …
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Drug repurposing against the store-operated calcium entry (SOCE) pathway and subsequent exploration of SOCE in oligodendrocyte progenitor cells
… Since oligodendrocytes progenitor cells (OPCs) play important role in MS due to their myelin forming ability upon differentiation, SOCE was characterized in OPCs using single cell Ca2+ imaging approach and effect of some SOCE inhibitory compounds were then evaluated for any role in OPC …
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DEVELOPMENT OF NEW OLIGODENDROCYTE-BASED MODELS TO IDENTIFY PHARMACOLOGICAL AGENTS WITH REMYELINATING ACTIVITY
… from oligodendrocyte precursor cells (OPCs) to their most mature form (mOLs). At intermediate stages, immature OLs (iOLs) transiently express in their cell membrane the G protein-coupled receptor 17 (GPR17). This expression is essential for their correct maturation; however, it needs to …
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