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Showing 1 to 18 of 18 for “"OMV"”.
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Bacterial Outer Membrane Vesicles. Mediators of virulence and antibiotic resistance.
Outer membrane vesicles (OMV) have the size of nanoparticles and are released from the outer membrane of most Gram-negative bacteria. The OMV reflect the composition of the bacterial outer membrane, including lipids and virulence factors specific for the pathogen, and are involved in pathogenesis …
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Brucella abortus Strain RB51 Outer Membrane Vesicles as a Vaccine Against Brucellosis in a Murine Model
… to prevent diseases caused by bacterial species. OMV are constantly released from Gram-negative bacteria. They are comprised principally of the outer membrane components and periplasmic proteins from the bacterial cell envelope. The research in this thesis examined the adjuvant property of …
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Studies on the synergistic protective activity of cancer antigens associated to engineered bacterial Outer Membrane Vesicles
Introduction Bacterial Outer Membrane Vesicles (OMVs) are naturally produced by all Gram-negative bacteria and are emerging as an attractive vaccine platform. The exploitation of OMVs in cancer immunotherapy was tested by decorating them with cancer epitopes and by following their capacity to …
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DUAL TARGETING OF RFAP AND FIMH IMPAIRS AIEC INTRACELLULAR SURVIVAL AND LIMITS OMV-DEPENDENT IL-23/PTH17 AXIS ACTIVATION, OFFERING A NOVEL THERAPEUTIC STRATEGY FOR CROHN¿S DISEASE
… we demonstrated for the first time that OMVs released by LF82 are sufficient to drive the pathogenic skewing of protective cTh17 cells into pathogenic IFN-γ-producing Th17 cells, thereby revealing a previously unrecognized mechanism through which AIEC promotes mucosal immune …
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Inhibition of extracellular vesicle release enhances cancer chemotherapy and inhibition of outer membrane vesicle release sensitises bacteria to antibiotic and bacteriophage therapy
… chemotherapy. Outer membrane vesicles (OMVs) are released by bacterial cells upon activation. Isolation and characterisation of these vesicles was carried out using differential centrifugation, ultrafiltration and nanoparticle tracking analysis. The presence of an arginine deiminase …
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Optimal Open Loop and Nonlinear Feedback Control for Remote Orbital Capture (multi-Body Dynamics, Recovery, Satellite Servicing, Payload Handling)
… a teleoperator or orbital maneuvering vehicle (OMV), can return the target satellite to low-Earth orbit for servicing and repair. The dynamics of the coupled two-body system are described with equations of motion derived from an Eulerian formulation (the Hooker-Margulies equations). Two degrees …
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Construction and characterization of proteome-minimized OMVs from E. coli and their exploitation in infectious disease and cancer vaccines
Bacterial Outer Membrane Vesicles (OMVs) are naturally produced by all Gram-negative bacteria and play a key role in their biology and pathogenesis. Over the last few years, OMVs have become an increasingly attractive vaccine platform for three main reasons. First, they contain several …
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Bacterial outer membrane vesicles (OMVs) as a platform for personalized cancer vaccines
… patients. Bacterial Outer Membrane Vesicles (OMVs) are naturally produced by all Gram-negative bacteria. They contain several Microbe-Associated-Molecular Patterns (MAMPs), crucial for stimulating innate immunity and promoting adaptive immune responses. The ability to engineer OMVs with cancer …
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Outer Membrane Vesicle Production in Escherichia coli Relieves Envelope Stress and is Modulated by Changes in Peptidoglycan
<p>Bacterial outer membrane vesicles (OMVs) are spherical buds of the outer membrane (OM) containing periplasmic lumenal components. OMVs have been demonstrated to play a critical part in the transmission of virulence factors, immunologically active compounds, and bacterial survival, however …
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The characterisation of Ornithogalum mosaic virus
Ornithogalum mosaic virus (OMV) is the most serious pathogen of commercially grown Ornithogalum and Lachenalia species in South Africa. Although omithogalum mosaic disease was first reported as early as 1940, attempts to purify or characterise the virus(es) were not successful. The extremely …
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Identification and characterization of a novel capsule-like complex surface antigen of Francisella tularensis
… of outer membrane vesicles and tubules (OMV/T). These OMV/T appeared to be self-aggregating into what I visualized through TEM as the CLC. LVSΔ1423-22 was attenuated in the mouse model, and BALB/c mice immunized with CLC and adjuvant were protected against challenge with LVS. In addition …
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Deep Reinforcement Learning for Multirotor Flight Control: A Comparative Study of Sim-to-Real Training and Real-World Performance
… to an omnidirectional multi-rotor vehicle (OMV). For the OMV, a learned Multi-Layer Perceptron (MLP) controller outperformed both adaptive and PID-based baselines when commanded to track a complex reference attitude, demonstrating stable six-degree-of-freedom trajectory tracking in …
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Bacteroides fragilis outer membrane vesicles are used for secretion of a discrete subset of bacterial RNAs that stimulate an immune response in colonic epithelial cells.
… as cargo in bacterial outer membrane vesicles (OMVs). The mechanisms by which human extracellular RNAs elicit immune responses have been well established, while the contribution of bacterial sRNA to host physiology remain unclear. We hypothesize that pathogenic and commensal microbes use …
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Analysis and optimization of immune responses elicited by Outer Membrane Vesicles (OMVs)
Outer membrane vesicles (OMVs) are spheroidal particles released from all gram-negative bacteria and exert different biological functions. OMVs carry many microbe-associated molecular patterns (MAMPs) such as peptidoglycan, lipopolysaccharide (LPS), and lipoproteins and can be decorated with …
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EM field effects on the surface of polluted HV insulators
… parallel to the insulator surface, up to 2. OMV/m. The contact angle between droplet and surface was varied by controlling the physical properties of the droplet and by inclining the insulator plane from the horizontal. A theoretical model is developed which shows that it is possible to …
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Abrasion-corrosion and stress corrosion resistance of a 9Cr-2Ni-0.7Mo steel in simulated mine water
… boundaries. Anodic potentials in the excess of OmV induced tunnel-like corrosion pitting attack. Fractographical evidence of sec at the base of these pits indicates the development of the conditions necessary for sec within the pit confines. This is cited as evidence in support of the hypothesis …
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Survival strategies of the human respiratory tract pathogen Haemophilus influenzae
… we also show that outer membrane vesicles (OMV) secreted by the bacteria carry Hsf, and that Hsf is secreted into the extracellular milieu. IgD-binding is another important feature of encapsulated H. influenzae type b. By using a series of different IgD chimeric proteins, the site on the IgD …
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Characterization of OmpT: An outer membrane vesicle protease Escherichia coli that attenuates blood coagulation.
… OmpT as part of outer membrane vesicles (OMVs), which inactivates coagulation Factor V and in so doing, induces a hemorrhagic state. To further characterize the effect of OmpT on the coagulation, this study has employed a genetic approach using wild type, an OmpT deletion mutant, and an …