Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"OHC"”.
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Development and validation of liquid chromatography mass spectrometry (L/C/MS/MS) assay for the determination of plasma 4betahydroxycholestrol and cholesterol in HIV infected children in Africa
4β-hydroxycholesterol (4β-OHC) is a metabolite of cholesterol formed by Cytochrome (CYP) 3A4/5/7 enzymes. It has recently been proposed as an endogenous biomarker forCYP3A4/5/7 activity. This may be useful in prediction of drug-drug interactions and other metabolic processes affected by regulators …
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Membrane tether formation from outer hair cells with optical tweezers
… mechanical properties of the outer hair cells (OHCs) lateral wall are essential to elucidate the mechanism of OHC electromotility. Optical tweezers were used to characterize the mechanical properties of OHC plasma membrane (PM) by pulling tethers. A greater force was required for tether …
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Developmental Alterations in the Distribution of Specific Lateral Wall Proteins Modify Outer Hair Cell Mechanical Properties
… mammalian cochlea, specialized outer hair cells (OHCs) housed within the organ of Corti exhibit nonlinear, mechanical responses to auditory stimulation [1]. These electromotile responses increase hearing sensitivity 100-fold (40 dB) and are responsible for frequency selectivity in the mammalian …
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The Signaling Pathway of Oxysterol Induced Apoptosis in Chinese Hamster Ovary (CHO)-K1 Cells.
… a potent oxysterol, 25-hydroxycholesterol (25-OHC). In the present study, we find that oxLDL can induce apoptosis in any cell types if cells present the specific receptors on their surface to take up oxLDL, and that apoptosis-inducing activity is associated with oxysterol components in oxLDL. …
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Effect of oncomodulin on cytoskeletal actin dynamics.
Cochlear outer hair cells (OHCs) contribute to the fine sensitivity of the mammalian auditory system by serving as a feedback mechanism in response to sound. Regulation of filamentous and globular actin may contribute to the reversible shape changes critical to OHC function. Previous studies have …
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Low-frequency bias-tone effects on auditory-nerve responses to clicks and tones : investigating multiple outer-hair-cell actions on auditory-nerve firing
Active motility in outer hair cells (OHCs) amplifies basilar-membrane (BM) and auditory-nerve (AN) responses to low-level sounds. The recent finding that medial olivocochlear (MOC) efferents (which innervate OHCs) inhibit AN initial peak (ANIP) responses from mid-to-high-level clicks, but do not …
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D-METHIONINE (D-MET) MECHANISMS UNDERLYING OTOPROTECTION FROM NOISE- AND AMINOGLYCOSIDE-INDUCED HEARING LOSS
… threshold shift analysis and outer hair cell (OHC) quantification. D-met doses ranging from 25-200 mg/kg/dose were administered to chinchillas every 12 hours five times each before and after steady state noise exposure totaling 10 D-met doses. Results demonstrated optimal, sub-optimal, and …
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Measurements and models of electrically-evoked motion in the gerbil organ of Corti
… inner ear, the outer hair cell. Outer hair cell (OHC) motility can occur at acoustic frequencies and play a key role in mammalian cochlear frequency selectivity and hearing sensitivity. To date, the mechanism of cochlear amplification is not well understood and remains a matter of controversy. In …
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Oral history and human rights: the archive and disability at Winnipeg's Oral History Centre
… practicum placement at the Oral History Centre (OHC), I was able to interview Sosa as well as immerse myself in the theoretical and practical aspects of the production of oral history archives. Working at the intersection of human rights and oral history, I realized that although I previously …
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Outcome measurement in articular cartilage repair: exploring the patient perspective
… to ACRpatients from an online health community (OHC) using a clinical impact methodology. The emergent pattern was one of function in sports and recreation activities being important for people who had undergone ACR, more than an anterior cruciate ligament reconstruction (ACLR) cohort from the …
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Investigating the suppressive effects of a low-frequency bias-tone on auditory-nerve responses to tail-frequency tones
… amplification from cochlear outer hair cells (OHCs). Specifically, sound vibrates the cochlear basilar membrane and this motion is transmitted to the OHC mechano-electric transduction function which produces a voltage change in the OHCs. This voltage change, through OHC electromotility, feeds …
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Factors associated with loss to follow-up after occupational HIV exposure among health care workers attending the Groote Schuur Hospital Occupational Health Clinic
… referral hospital’s Occupational Health Clinic (OHC) in Cape Town, South Africa, for post-exposure prophylaxis (PEP) during a period when tenofovir (TDF) was available. Data was obtained from an existing database maintained by the OHC. Our primary outcome was to identify factors associated with …
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Characterisations of Different El Nino Types, their Physical Causes and Predictions
… in locations of positive Ocean Heat Content (OHC) anomalies. Intensity, longitudinal coverage and duration of a WWB, the strength of the OHC anomaly and gradient influence the amplitude of Kelvin waves as they propagate. Synoptic pattern analysis suggests that most WWBs are caused by cyclones …
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Evidence-informed policy development and enactment: A policy content evaluation of a provincial policy for improving the educational outcomes of youth in out-of-home care in Ontario
… of students living in out-of-home care (OHC) throughout Ontario during the year (2015–2016) the JPSA was released. Analyses revealed that students in OHC had higher short-term absentee rates, suspension and expulsion rates, special education placement, and rates of school transfers …
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Clinical and Molecular Characterization of Auditory Neuropathy
… response (ABR) is absent and outer hair cells (OHC) function normally, which indicates that the lesion lies in the inner hair cells (IHC), their afferent nerve’s synapse or the auditory nerve. While the presence of non-syndromic recessive multiplex families is relatively rare, it suggests that a …
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A feedback analysis of outer hair cell dynamics
Outer hair cells (OHCs) generate active forces in the mammalian cochlea. Acting as cochlear amplifiers, OHCs can counteract viscous drag, generating high gain at characteristic frequencies and allowing for the sharp frequency selectivity and sensitivity observed in mammals. Excitatory displacement …
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Production of Protein Concentrates from Brewer's Spent Grain via Wet Fractionation and Enzymatic Purification
… the solubility, foaming capacity, WHC, and OHC of the BSG protein. Potential applications for the DPC include low moisture applications such as protein bars or granola. The DPCs could also have potential use in meat alternatives due to the high WHC and OHC and the need for varying protein …
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Elektronen-Spin-Resonanz-Datierung von Quarz : Grundlagen, Systematik und Anwendungen unter Einbeziehung der Thermolumineszenz
… und schwache oder nicht-existente E1'- und OHC-Signale werden als möglicher Nachweis einer vollständigen Nullstellung diskutiert.
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Measuring material properties of tectorial membranes from normal and genetically modified mice
… and plays a key role in driving outer hair cell (OHC) bundle deflection. At the same time, the TM bulk modulus is dominated by the presence of fixed charge and may play a key role in coupling energy from outer to inner hair cells.
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The outer spiral network and its innervation by the olivocochlear system
Outer hair cells (OHCs) are key elements of the mammalian hearing system, which amplify sound-evoked signals transmitted into the inner ear. OHCs are innervated by peripheral projections of olivocochlear (OC) and type-II spiral ganglion neurons. Type-II neurons innervate up to 100 OHCs, but their …
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