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Showing 1 to 1 of 1 for “"OGDH complex"”.
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The role of ABHD11 in the regulation of the hypoxia inducible transcription factors
… metabolism is the 2-oxoglutarate dehydrogenase complex (OGDHc) – a rate limiting step for conversion of 2-OG to succinyl-CoA within the TCA cycle. Genetic disruption of the OGDHc leads to HIF stabilisation through the accumulation of 2-OG and formation of L-2-hydroxyglutarate, an inhibitor of …