Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"OGDH"”.
-
Studies on lipoic acid metabolism
… (PDH) and oxoglutarate dehydrogenase (OGDH) is essential for their activation and thus for respiratory growth in the bacterium Escherichia coli and the yeast Saccharomyces cerevisiae. A third lipoic acid-dependent enzyme system, the glycine cleavage system (GCV), is required for …
-
Studies of Lipoic Acid Metabolism in Escherichia Coli
… using octanoylated forms of the PDH and 2-OGDH as substrates revealed that the inactive octanoylated dehydrogenases were converted to their active forms upon restoration of LipA function. These data demonstrate an unprecedented synthetic pathway whereby a covalently bound enzyme cofactor is …
-
Decoding Lysine-11 Signals in Ubiquitination
The diverse outcomes of ubiquitination primarily relate to the flexibility of ubiquitin in forming homo- or heterotypic chains on each of its seven lysine residues which in turn stimulate distinct downstream signaling pathways. These ubiquitin signals must be selectively initiated on the substrate …
-
The role of ABHD11 in the regulation of the hypoxia inducible transcription factors
… is the 2-oxoglutarate dehydrogenase complex (OGDHc) – a rate limiting step for conversion of 2-OG to succinyl-CoA within the TCA cycle. Genetic disruption of the OGDHc leads to HIF stabilisation through the accumulation of 2-OG and formation of L-2-hydroxyglutarate, an inhibitor of PHDs. …