Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"OCULAR DRUG DELIVERY"”.
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Dendrimer Based Nanotherapeutics For Ocular Drug Delivery
… nanocarriers that are being investigated for ocular drug and gene delivery. Their favorable properties such as small size, multivalency and water solubility can provide significant opportunities for many biologically unstable drugs and allows potentially favorable ocular biodistribution. This …
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Cell penetrating peptide for ocular drug delivery
… cascade in various in vitro and in vivo ocular models. Gap19 is an intracellularly acting connexin mimetic peptide, said to be Cx43 HC specific without effecting cell-to-cell communication. Gap19, however, has low cell permeability. To improve cell uptake, Gap19 was fused with the cell …
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Towards an improved ocular drug delivery system
… which will improve the efficiency of ocular drug delivery systems. Initially, it was necessary to review the information available on the nature of the tear fluid and its relationship with the eye. An extensive survey of the relevant literature was made. There is a common belief in the …
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Conducting Polymer Implant for On-demand Ocular Drug Delivery
… for implantation to provide stimuli-responsive ocular drug delivery. Methods: PEDOT films (non-porous and porous) were fabricated via vapour phase polymerisation (VPP) and characterised for their surface morphology, electrochemical behaviour and biocompatibility. Dexamethasone phosphate (dexP) …
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Formulation, Scaled & Controlled Engineering of Fibrous Dosage Technologies for Ocular Drug Delivery
… barriers which significantly hinder efficient ocular drug delivery. The use of conventional formulations e.g. eyedrops, although widely used, are limited in their retention time and poor bioavailability with less than 5% of the administered dose reaching intraocular tissues. As a result, …
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Topical Clear Aqueous Nanomicellar Formulations For Anterior And Posterior Ocular Drug Delivery
… of this study was to develop a clear, aqueous drug loaded nanomicellar formulation (NMF) for the back-of-the-eye delivery. Hydrophobic drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone, rapamycin were entrapped in the core of polymeric micelles and solubilized. Polymeric …
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Long Term Ocular Drug Delivery with Novel Pentablock Copolymers; Part I: Composite Nanoformulation of Macromolecules For Back of the Eye Diseases, Part II: Dexamethasone Nanoparticle to Develop an In Vitro Model for Glaucoma
… have been successfully synthesized for long term delivery in the treatment of posterior segment ocular diseases. PB copolymers are comprised of FDA approved biodegradable polymer such as polyethylene glycol (PEG), polycaprolactone (PCL), polylactic acid (PLA) and polyglycolic acid (PGA). PB …
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Design and Development of Solid Lipid Nanoparticles for Ocular Delivery of Acyclovir
Background and aim: Ocular infections caused by Herpes keratitis remain the leading cause of infectious blindness in the developed world and there is a need for the development of a novel drug delivery system to improve treatment options. The complex structure of the eye poses several challenges …
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Current Strategies and New Avenues in the Management of Non-Infectious Ocular Inflammation
Non-infectious ocular inflammation is one of the major cause of blindness worldwide and often heralds the onset of systemic autoimmune pathologies. They are thought to progress through certain sequential phases and many factors such as microbiome disturbances and infections increase the general …
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Advanced Engineering of Contact Lens Coatings using Electrohydrodynamic Atomization
While the eye presents numerous opportunities for drug delivery (DD); there are many challenges met by conventional methods. Despite the exponential growth in research to overcome these downfalls and achieve sustained and controlled DD, the anatomical characteristics of the eye still pose …
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Biopharmaceutic and Pharmacokinetic Evaluation of Hesperidin and Hesperetin for Ocular Delivery
… characteristics of hesperidin and hesperetin for ocular delivery, especially with respect to the distribution of these compounds to the posterior segment of the eye. Hesperidin and hesperetin were found to be water insoluble compounds. Although they demonstrated good permeability across the ocular …
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Therapeutic contact lenses for extended drug delivery
There is significant interest in hydrogel-based drug-eluting contact lenses as platforms for topical ocular drug delivery. These devices have shown to provide an increased residence time of drugs at the surface of the eye, leading to enhanced bioavailability (~ 50%) when compared to eye drops …
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Novel drug interaction for improving intracellular accumulation and efficacy of chemotherapeutics in retinoblastoma and mitochondrial localization of transporters in corneal epithelial cells
… due to major interaction with multidrug resistant (MDR) efflux proteins (MDR1 and MRP2) over-expressed on retinoblastoma tumor. Ocular cells have shown good tolerability against antimicrobial moxifloxacin (fourth generation fluoroquinolone) at higher dose level. As majority of …
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SELECTION OF TARGETING MOIETIES DRIVING NANOPARTICLE PENETRATION THROUGH SQUAMOUS PLURISTRATIFIED EPITHELIA
Drug delivery through stratified squamous epithelia is crucial for treating various local and systemic conditions. Nevertheless, the administration through these kinds of epithelia, like the skin, the esophageal membrane, and the corneal membrane, poses significant challenges due to their complex …
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Geothermal Resource Assessment of Mississippi
Geothermal energy is exploited through the process of using hot water or steam extracted from reservoirs of geothermal heat in Earth's crust which is derived from the upward convection and conduction of heat from Earth’s mantle and core. This energy can be harnessed to power geothermal heat pumps, …
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Ocular Iontophoresis of Nanocarriers for Sustained Drug Delivery to the Eye
… as a viable modality to deliver therapeutic drugs for the treatment of eye diseases. Although several studies have been conducted to examine the utility of iontophoresis for both charged and neutral molecules, the understanding of the mechanisms controlling the iontophoretic delivery of …
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Sviluppo di nanomedicine per la somministrazione oculare di farmaci
La prevalenza delle malattie neurodegenerative oculari è in aumento nella popolazione anziana ma anche tra i giovani. Questi disturbi causano la compromissione e la riduzione della vista e, nei casi più gravi, portano alla cecità irreversibile. L'eziologia non è del tutto chiara, i meccanismi …