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Showing 1 to 2 of 2 for “"OCTN2"”.
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IN SILICO CHARACTERIZATION OF THE RECOGNITION MECHANISM OF RIBOFLAVIN TRANSPORTERS RFVT1, RFVT2, AND RFVT3, AND ORGANIC CATION TRANSPORTERS OCTN1 AND OCTN2
Questa tesi esplora le caratteristiche strutturali e funzionali dei trasportatori della famiglia SLC (solute carrier), identificati come promettenti bersagli per scopi farmacologici. Questi trasportatori transmembrana sono elementi fondamentali per l'omeostasi cellulare, e alterazioni nella loro …
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Studies of the expression and characterization of various transport systems at RBE4 cells, an in vitro model of the blood-brain barrier
… and the organic cation/carnitine transporter OCTN2, was shown at the RBE4 cells. Uptake studies with radiolabeled 5-HT exhibited a saturable, sodium dependent transport at RBE4 cells with a Kt value of about 0.40 µM and a Vmax of about 52 fmol/mg/min. L-carnitine and TEA (tetraethylammonium) …