Global ETD Search
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Showing 1 to 13 of 13 for “"OC43"”.
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Animal models for investigating coronavirus heterotypic immunity
Endemic coronaviruses (CoVs) such as OC43 circulate seasonally and, while usually mild, represent the 6th leading cause of viral pneumonia. Additionally, multiple zoonotic spillovers of CoVs have occurred in the last 25 years to cause severe pneumonia, most recently the coronavirus disease 2019 …
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BETACORONAVIRUSES OPTIMIZE REPLICATION BY BALANCING ANTAGONISM OF INNATE IMMUNE RESPONSES AND ER STRESS RESPONSES
… disease outcomes in infected humans: HCoV-OC43, a common cold virus; MERS-CoV, which caused an epidemic of severe pneumonia in the Arabian Peninsula with a 36% case fatality rate; and SARS-CoV-2, the causative agent of the COVID-19 pandemic, which induces disease ranging from asymptomatic …
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Receptor Binding Domains and Coronavirus Adaptation and Evolution
… cold causing coronaviruses: HCoV-229E and HCoV-OC43. Specifically, the X-ray crystal structures of the following were determined: i) the receptor binding domain (RBD) of the S-protein of HCoV-229E in complex with human aminopeptidase N (hAPN) and ii) the carbohydrate binding domain (CBD) of the …
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Dissecting the Novel Roles of TRIM56 in Antiviral Innate Immunity
… (DENV2), and human coronavirus virus (HCoV)-OC43. Moreover, I demonstrate that TRIM56’s anti-flavivirus effects required both the E3 ligase activity that lies in the N-terminal RING domain and the integrity of its C-terminal portion, while the restriction of HCoV-OC43 relied upon the TRIM56 …
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The burden of human coronavirus infection in children hospitalized with severe lower respiratory tract infection in Cape Town, South Africa (2012-2013)
… and burden of human coronaviruses - NL63, HKU1, OC43 and 229E in South Africa, their role in the aetiology of childhood pneumonia needs to be described. Methods: We used data collected between September 2012 – September 2013 from children aged < 13 years with lower respiratory illness at Red …
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Human coronavirus NL63 envelope protein-protein interactions: role in pathogenesis
… four other HCoVs—HCoV-229E, HCoV-NL63, HCoV-OC43, and HCoV-HKU1—are associated with milder, more frequent, and seasonal respiratory tract infections. Of the four canonical coronavirus structural proteins, the envelope (E) protein remains the least well-characterised, despite its critical …
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Antibody production with synthetic peptides against human Coronavirus-NL63 ORF3 protein
… to note that CoV‐NL63, CoV‐229E, CoVHKU1 and CoV‐OC43 infect polarized epithelial cells, and the entry and release of these viruses are related to apical cells in addition to respiratory signs, there are two non-respiratory symptoms including gastroenteritis and Kawasaki disease, both of which are …
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Broad-spectrum antivirals against coronavirus using natural products and drug repurposing strategies
… phytochemicals exhibited activity against OC43 and HCoV-229E, with select compounds demonstrating low cytotoxicity and promising antiviral profiles. Chapter five shifts to host-targeting strategies through the repurposing of PROTACs (Proteolysis-Targeting Chimeras). Originally developed for …
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Multifunctional Coronavirus Papain-Like Proteases as Targets for Antiviral Therapeutics and Vaccines
… and deubiquitinase activity of PLP2s from HCoV-OC43, HCoV-229E, HCoV-HKU1, MHV and FIPV.</p><p>To evaluate the role of PLP during virus replication and pathogenesis I utilized two approaches and a mouse model system, mouse hepatitis virus (MHV). First, I performed deletion analysis and …
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Regulation of IRF-3-Dependent Innate Immune Signaling Pathway by the PLpro Domain of Non-Structural Protein 3 (NSP3) of Severe Acute Respiratory Syndrome (SARS) Coronavirus
… expression of the full length nsp3 of HCoV-OC43, HCoV-NL63, MERS-CoV, and SARS-CoV, respectively. Although these cell lines exhibited stable and tight control of nsp3 expression in the presence of tetracycline, I observed a variation in CoV’s nsp3 protein expression levels. However, …
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The Genetic, Molecular, And Cellular Bases Of Unidentified Primary Immunodeficiencies
… including human rhinovirus, coronaviruses (HKU1, OC43, NL63), influenza virus, and respiratory syncytial virus. The mutant protein lost the ability to bind dsRNA and failed to initiate antiviral interferon-β and pro-inflammatory NF-κB responses. Using gene knockdown and gene editing in …
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Functional Investigation of RNA Viral Helicases as Molecular Targets for the Discovery of Novel Antiviral Agents
… activity against SARS-CoV-2, MERS-CoV, hCoV-OC43, and hCoV-229E. Mode of action studiesn suggested an ATP non-competitive inhibitory mechanism, likely targeting an allosteric pocket on the RecA2 domain. A rational design targeting the ATP-binding site region of SARS-CoV-2 NSP13 identified the …
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INFECTION- AND VACCINE-INDUCED IMMUNE RESPONSES TO SARS-COV-2 AND OTHER HUMAN CORONAVIRUSES
… between the human common cold coronaviruses, OC43 and HKU1 while antibody cross-reactivity was minimal. HCW sample screening revealed universal seropositivity to human common cold coronaviruses, but low or undetectable T cell responses. Following in vitro expansion and epitope mapping …