Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"OBHS"”.
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Development of Novel anti-estrogens for endocrine resistant Breast Cancer
… acid phenyl ester, termed OBHS, which reduces gene activation through ligand-induced shifts in helices 8 and 11, thereby indirectly modulating helix 12 of ER (hence, indirect antagonists). This new class of ligands with a bicyclic hydrophobic core retains strong …
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I. Estrogen receptor-mediated inhibition of inflammatory signaling: Implications for treatment of breast cancer II. Small molecule coactivator-binding inhibitors
… anti-inflammatory activity of a lead compound, OBHS, is described. A crystal structure of OBHS bound to the estrogen receptor provided the basis for structural and functional analogs of OBHS. These compounds exhibited weaker binding to the estrogen receptor than OBHS; however some displayed …
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The Relationship Between Professional Learning Communities and Instructional Practices
… and focus on PLCs, Ocean Breeze High School's (OBHS) academic achievement proficiency grew from 48.6% to 87.5% within a three-year period. Based on this phenomenal progress, this case study investigated the relationship between PLC characteristics and instructional practices at this school. The …