Global ETD Search

Identification of OATP1B3 as a potential therapeutic target in Recessive Dystrophic Epidermolysis Bullosa Associated Squamous Cell Carcinoma

Cole, Clare LouiseUniversity of Dundee2011

… SLCO1B3 encodes the organic anion transporter OATP1B3, which is normally exclusively expressed on the basolateral membrane of hepatocytes. qRT-PCR revealed the mRNA expression level of SLCO1B3 is reduced in RDEB SCC keratinocyte cultures when COL7A1, the causal gene mutated in RDEB, is …

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Age-Associated Expression Patterns of OATP 1B1 and OATP 1B3 and Their Effect on the Disposition of Fexofenadine

Thomson, Margaret Mary2018

… of the drug removal organs. OATP1B1 and OATP1B3 are transporters on the sinusoidal membrane of the liver which work in concert with the drug metabolizing enzymes as part of the drug removal process. It is known that the development of each drug metabolizing enzyme follows a unique pattern …

tenn-hsc Repository record for Age-Associated Expression Patterns of OATP 1B1 and OATP 1B3 and Their Effect on the Disposition of Fexofenadine (opens in a new tab)

Flaxseed Lignan Metabolites Modulate Hepatocellular Cholesterol Trafficking In HepaRG

Hawsawi, Ahlam Ahmad 1982-University of Saskatchewan2018

… in HEK293 cells overexpressing human OATP1B1 & OATP1B3 transporters. Under high intracellular sterol conditions, both ENL and ENL-Gluc reduced the uptake of fluorescent cholesterol into HepaRG cells. In comparison to vehicle control (1% DMSO), treatment with 20 µM ENL and 20 µM ENL-Gluc reduced …

sask Repository record for Flaxseed Lignan Metabolites Modulate Hepatocellular Cholesterol Trafficking In HepaRG (opens in a new tab)

Clinical Pharmacology of MS-275, A Histone Deacetylase Inhibitor

Acharya, Milin R.2014

… organic anion transporting proteins, OATP1B1 and OATP1B3, nor a substrate for gastrointestinal efflux transporters ABCB1 (P-gp) or ABCG2. No significant correlation was found between CL/F and demographic, body measures and other clinical covariates, and inter-patient variability in CL/F remained …

vcu Repository record for Clinical Pharmacology of MS-275, A Histone Deacetylase Inhibitor (opens in a new tab)

Die Expression von SLCO1B3 in Kopf-Hals-Tumoren und dessen Einfluss auf die Chemosensibilität

Engelhardt, Heinrich Alexander MartinUniversität Ulm

ulm-diss Repository record for Die Expression von SLCO1B3 in Kopf-Hals-Tumoren und dessen Einfluss auf die Chemosensibilität (opens in a new tab)

Is the door closed? : In vitro studies on the pharmacokinetic effects of OATP1B1 gene-drug and drug-drug interactions.

Kiander, WilmaHelsingin yliopisto2023

… that ticagrelor inhibits OATP1B1, OATP2B1 and OATP1B3 with IC50 values in the low micro molar range. However, when taking into account the unbound concentration at the hepatic inlet, clinical interaction is unlikely and the primary cause was accredited to inhibition of intestinal breast cancer …

helsinki Repository record for Is the door closed? : In vitro studies on the pharmacokinetic effects of OATP1B1 gene-drug and drug-drug interactions. (opens in a new tab)