Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"OATP1B3"”.
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Identification of OATP1B3 as a potential therapeutic target in Recessive Dystrophic Epidermolysis Bullosa Associated Squamous Cell Carcinoma
… SLCO1B3 encodes the organic anion transporter OATP1B3, which is normally exclusively expressed on the basolateral membrane of hepatocytes. qRT-PCR revealed the mRNA expression level of SLCO1B3 is reduced in RDEB SCC keratinocyte cultures when COL7A1, the causal gene mutated in RDEB, is …
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Age-Associated Expression Patterns of OATP 1B1 and OATP 1B3 and Their Effect on the Disposition of Fexofenadine
… of the drug removal organs. OATP1B1 and OATP1B3 are transporters on the sinusoidal membrane of the liver which work in concert with the drug metabolizing enzymes as part of the drug removal process. It is known that the development of each drug metabolizing enzyme follows a unique pattern …
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Flaxseed Lignan Metabolites Modulate Hepatocellular Cholesterol Trafficking In HepaRG
… in HEK293 cells overexpressing human OATP1B1 & OATP1B3 transporters. Under high intracellular sterol conditions, both ENL and ENL-Gluc reduced the uptake of fluorescent cholesterol into HepaRG cells. In comparison to vehicle control (1% DMSO), treatment with 20 µM ENL and 20 µM ENL-Gluc reduced …
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Clinical Pharmacology of MS-275, A Histone Deacetylase Inhibitor
… organic anion transporting proteins, OATP1B1 and OATP1B3, nor a substrate for gastrointestinal efflux transporters ABCB1 (P-gp) or ABCG2. No significant correlation was found between CL/F and demographic, body measures and other clinical covariates, and inter-patient variability in CL/F remained …