Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"OATP1B1"”.
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Structural and functional investigation of the organic anion transporting polypeptide 1B1 (OATP1B1)
Membrane transport proteins are the gatekeepers of the cell membrane, transporting compounds in and out of the cell. The organic anion transporting polypeptides (OATPs) are a family of transport proteins expressed in a variety of tissues, including absorptive I excretory cells of the liver and …
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Age-Associated Expression Patterns of OATP 1B1 and OATP 1B3 and Their Effect on the Disposition of Fexofenadine
… the biomembranes of the drug removal organs. OATP1B1 and OATP1B3 are transporters on the sinusoidal membrane of the liver which work in concert with the drug metabolizing enzymes as part of the drug removal process. It is known that the development of each drug metabolizing enzyme follows a …
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Flaxseed Lignan Metabolites Modulate Hepatocellular Cholesterol Trafficking In HepaRG
… examined in HEK293 cells overexpressing human OATP1B1 & OATP1B3 transporters. Under high intracellular sterol conditions, both ENL and ENL-Gluc reduced the uptake of fluorescent cholesterol into HepaRG cells. In comparison to vehicle control (1% DMSO), treatment with 20 µM ENL and 20 µM …
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Clinical Pharmacology of MS-275, A Histone Deacetylase Inhibitor
… organic anion transporting proteins, OATP1B1 and OATP1B3, nor a substrate for gastrointestinal efflux transporters ABCB1 (P-gp) or ABCG2. No significant correlation was found between CL/F and demographic, body measures and other clinical covariates, and inter-patient variability in …
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The pharmacologenetics of lopinavir in a cohort of black African HIV/AIDS patients
… and CYP3A5; the hepatic uptake transporter, OATP1B1; and the efflux transporter, MRP2. Variation in the genes encoding these proteins may influence their functioning and hence LPV disposition. The aim of the study was to identify significant single nucleotide polymorphisms (SNPs) in each …
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The significance of OATP and CYP450 in statin-flavonoid interactions
… A were identified to be inhibitors of CYP3A4 and OATP1B1 which are pathways important to statin uptake and metabolism. Additionally, there are implications for these flavonoids to have pharmacodynamic interactions with statins through the cholesterol synthesis pathway. The risk for statin-induced …