Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"OAS1"”.
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The Evolution of the Viral RNA Sensor OAS1 in Old World Monkeys and Cetartiodactyls
… thesis includes a population level analysis of OAS1 diversity within macaque and baboon species followed by a broader survey of the gene in nineteen Old World monkeys. My research found that at the species level, macaques exhibit extremely high diversity with intriguing similarities to that …
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The Role of Interferon Stimlated Genes in Resistance and Immunity to Hepatitis C Virus Infection
… variant of the oligoadenylate synthetase 1 (OAS1) gene in resistance to HCV infection, an integrated approach of epidemiology, molecular genetics, and functional biology was used. Genetic and epidemiologic analyses identified a single-base mutation in OAS1 that associates with HCV resistance …
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Prenylation in cell-intrinsic innate immunity to positive-strand RNA viruses
… protein (ZAP) and oligoadenylate synthetase 1 (OAS1). The long isoform of ZAP, ZAP-L, is prenylated and targeted to endosomes and lysosomes. This localization is critical for its antiviral activity against alphaviruses, which use those compartments for RNA replication. The cytosolic short …
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Cancer Cell Antiviral Signaling Amplifies Transcription Output Through Chromatin Alterations To Drive Therapy Resistance
… (PRR), 2’-5’-oligoadenylate synthetase 1 (OAS1). OAS1 amplifies the IFN-I pathway in cancer cells, which increases multiple immune inhibitory genes. Accordingly, abrogating IFN-I signaling in cancer cells restores IFN signaling in immune populations and broadly improves immune function. …
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Genetic Variations in Interferon-Induced Genes and HCV Recurrence after Liver Transplantation
Hepatitis C Virus (HCV) infection represents a worldwide pandemic and is currently the leading cause of cirrhosis and liver transplantation. After transplantation recurrence is almost universal with 96% of patients testing positive for viral RNA and exhibiting histological evidence of infection …