Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"O6-methylguanine-DNA methyltransferase (MGMT)"”.
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THE ROLE OF ACTIVE AND ACTIVE-SITE ALKYLATED HUMAN O6-METHYLGUANINE-DNA METHYTRANSFERASE (MGMT AND R-MGMT) IN DNA REPAIR AND BIOMONITORING
… antibodies raised against recombinant human MGMT were characterized and used to study the role of active and active-site alkylated human O6-methylguanine-DNA methyltransferase (MGMT and R-MGMT) in DNA repair and biomonitoring. The human DNA repair enzyme O6-methylguanine-DNA methyltransferase …
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Development of imidazotetrazines for the treatment of glioblastoma & as synthetic precursors to diazo species
… adjuvant temozolomide (TMZ), a small molecule DNA alkylating agent. The antitumor effect of TMZ is ultimately mediated through methylation of the O6-position of guanine and subsequent mismatch repair (MMR)-dependent cell death. Although TMZ was first synthesized in 1984 and has been FDA …
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Characterising Heterogeneity of Glioblastoma using Multi-parametric Magnetic Resonance Imaging
… than structural images for predicting O6-methylguanine-DNA methyltransferase (MGMT) methylation status. For predicting 12-month PFS, the model of radiomic features and clinical factors outperformed the model of MGMT methylation and clinical factors (P = 0.010). In summary, pre-operative …
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Metabolism of lomustine in dogs and comparative cytotoxicity of lomustine and its major metabolites and O6-methylguanine-DNA methyltransferase expression in canine cells
… and its metabolites form similar levels of the DNA adducts N7 hydroxyethylguanine and O6 hydroxyethyldeoxyguanosine. These adducts may be used as molecular dosimeters of therapeutic response thus correlating to the similar cytotoxicity of these compounds. In terms of carbamylation, lomustine …