Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"O-carboxyanhydrides"”.
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Development of Controlled Ring-Opening Polymerization of O-Carboxyanhydrides
… of ring-opening polymerization (ROP) of O-carboxyanhydrides (OCAs) to synthesize functionalized, degradable polyesters. Biodegradable polyesters are promising alternatives to conventional petroleum-based non-degradable polyolefins and they are widely used in everyday applications ranging …
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Synthesis of Functionalized Sustainable Polyesters via Controlled Ring-opening Polymerization of O-carboxyanhydrides
… functionalized poly(α-hydroxy acids) from O-carboxyanhydrides have been hampered by scalability problems arising from the need for an external energy source such as light or electricity. Herein, an operationally simple, scalable method for synthesizing stereoregular, high-molecular-weight …
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Fighting cancer with nanomedicine−drug-polyester nanoconjugates for targeted cancer therapy
… NC system based on poly(lactic acid) and poly(O-carboxyanhydrides) (OCA) that allows for the quantitative loading and controlled release of a variety of anticancer drugs. The developed NC system could be easily modified with parmidronate, one of bisphosphonates commonly used as the treatment for …
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Poly(α-hydroxyalkanoic acid): Polymerization methodology, materials, and applications
… acids) from α-hydroxy acid O-carboxyanhydrides (OCA) monomers. Bon careful screening of ligand and initiator, (BDI)Zn-1 ((BDI-IE)Zn(OCH(CH3)COOCH3), (BDI-IE) = 2-((2,6-diethylphenyl)amino)-4-((2,6-diisopropylphenyl)imino)-2-pentene)) were developed for the controlled ROP of …
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Development of polymeric drug delivery vehicles for targeted cancer therapy
The aim of my Ph. D. thesis is to generalize a method for targeted anti-cancer drug delivery. Hydrophilic polymer-drug conjugates involve complicated synthesis; drug-encapsulated polymeric nanoparticles limit the loading capability of payloads. This thesis introduces the concept of nanoconjugates …