Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Nutrient deprivation"”.
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NOVEL MECHANISMS FOR PROTEIN SYNTHESIS REGULATION DURING STRESS
… to overcome the environmental stresses, such as nutrient deprivation and disease. Although many animal and human studies have reported changes in protein synthesis rates under various conditions, little is known about the mechanism that regulate protein synthesis in different tissues and during …
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Polyploidy in Saccharomyces cerevisiae leads to the loss of cell cycle control in stationary phase
… rapidly lose viability under conditions of nutrient deprivation. In contrast to isogenic haploids that remain viable for weeks and even months, tetraploid yeast are completely inviable after approximately 10-15 days in synthetic media. Analysis of the growth patterns of haploid and …
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Regulation of Protein Degradation In The Heart By Amp-Activated Protein Kinase
… is AMP-activated protein kinase (AMPK). During nutrient deprivation, AMPK is activated and intracellular proteolysis is enhanced through the ubiquitin proteasome system (UPS). Whether AMPK plays a role in protein degradation through the UPS in the heart is not known. Here I present data in …
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Regulation of Protein Degradation In The Heart By Amp-Activated Protein Kinase
… is AMP-activated protein kinase (AMPK). During nutrient deprivation, AMPK is activated and intracellular proteolysis is enhanced through the ubiquitin proteasome system (UPS). Whether AMPK plays a role in protein degradation through the UPS in the heart is not known. Here I present data in …
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Nutrient Sensing in Immune Function: A Systems Biology Approach
Nutrient deprivation through caloric restriction or time-controlled fasting has a profound impact on reducing risk factors and symptoms of inflammatory disease. Studies have highlighted the immune-modulatory and anti-inflammatory effects of nutrient deprivation, suggesting a critical role for …
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Investigating the Role of PARylation in Regulating Skeletal Muscle Mass and Function in Healthy Mature Mice
… in response to physiological stressors (i.e., nutrient deprivation, oxidative stress, DNA strand breaks). Poly-ADP-ribosylation (PARylation) is primarily mediated by the family of poly(ADP-ribose) polymerases (PARPs) and enzymatically degraded (dePARylation) by hydrolases such as …
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Mechanobiology of the nucleus pulposus: The effect of hydrostatic pressure and glucose deprivation on nucleus pulposus cell sub‐populations
… to be initiated by mechanical stress and/or nutrient deprivation. This study aimed to investigate the phenotypic and functional differences between NC and MNP cells in response to a range of hydrostatic pressures and glucose concentrations. In this study a novel isolation method was developed …
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Modeling The Unfolded Protein Response And Its Connection To Cellular Stress
… (UPR). Cellular stresses range from hypoxia, nutrient deprivation to external stimulus such as heat or radiation. It is vital to understand the complexities involved in this system, to predict the role of UPR in cancer, diabetes and other diseases associated with misfolded proteins. In the …
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Using Deep Learning to Extract Multicellular Aggregation Features of Myxococcus xanthus
… aggregation and fruiting body formation under nutrient deprivation, offers a powerful model for studying these dynamics. This thesis addresses both methodological and analytical challenges in studying M. xanthus development. To overcome the limitations of traditional imaging (e.g., difficulty …
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Comprehensive metabolite analysis in Chlamydomonas reinhardtii : method development and application to the study of environmental and genetic perturbations
… in their concentration during adaptation to nutrient deprivation. Metabolite profiling allowed characterization of both specific and general responses to nutrient deprivation at the metabolite level. Modulation of the substrates for N-assimilation and the oxidative pentose phosphate pathway …
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Mathematical modeling of molecular mechanisms governing cell cycle progression in Caulobacter crescentus and differentiation of immune system progenitor cells
… G1-S transition. Furthermore, we incorporate a nutrient signaling model into the cell cycle model to investigate how Caulobacter responds to nutrient deprivation. We find that regulation of DivK phosphorylation is an essential component of the nutrient signaling pathway and demonstrate how …
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Microfluidic perfusion culture for controlling the stem cell microenvironment
… that proliferation is achieved while avoiding nutrient deprivation and high shear stress regimes, we developed novel logarithmic flow-rate devices for characterizing mESC behavior across a wide range of flow rates simultaneously. We observed both flow-rate and location-dependent proliferation …
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Mitochondrial Structure-Function in health and disease
… respiration after peroxide and hypoxia nutrient deprivation injuries. Using two parallel electron microscopy paradigms, we show elamipretide and RYKF treatment led to maintenance of mitochondrial ultrastructure and notably, improved cristae interconnectedness. Finally, we utilized a …
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Phenothiazines Induce Abortive Autophagy Leading to Cancer Cell Death
… maintain homeostasis and provides energy during nutrient deprivation and environmental stresses for the survival of cells by delivering cytoplasmic contents to the lysosomes for recycling and energy generation. Dysregulation of this process has been linked to human diseases including immune …
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LINKING HISTONE LACTYLATION TO THE EPIGENETIC REPROGRAMMING OF CD4+ T REGULATORY LYMPHOCYTES IN THE TUMOR ECOSYSTEM
… (TME), which is characterized by nutrient- deprivation, hypoxic conditions and accumulation of lactic acid. Here we describe our findings on epigenetic and metabolic reprogramming of TI-Treg, mediated by lactic acid which fuels their suppressive function. Using integrated …
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Differential membrane-type matrix metalloproteinase expression in phenotypically defined breast cancer cell lines: Comparison of MT-MMP expression in environmentally-challenged 2D monolayer cultures and 3D multicellular tumour spheroids
… conditions, including hypoxia and nutrient deprivation (serum-free induced autophagy) were measured in MCF-7 monolayer cultures and MCTS models using immunofluorescence (IF), immunohistochemistry (IHC) and western blot (WB). MT1-MMP expression was rapidly and irreversibly …
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Pathways of intracellular protein degradation in cultured muscle cells
… increased activity of the lysosomes. Nutritional deprivation did not increase the rate of degradation of short-lived proteins. The results were clarified by the parallel use of the well-characterized LDL degradation system in this cell type, known to occur almost exclusively via lysosomes. This …
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The dynamic interplay between DNA damage and metabolism : the metabolic fate and transport of DNA lesions and novel DNA damage derived from intermediary metabolism
… fungi under changing conditions of environmental nutrients. The goal of this project was to characterize DNA adducts caused by glyoxylate in the mycobacterium M. smegmatis, with the studies motivated by the higher-than-expected mutation rate of mycobacteria during dormancy induced by nutrient …
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Interactions of insect herbivory and multiple abiotic stress agents on two wetland tree species in southeast Louisiana swamps
… incorporating these environmental stressors and nutrient enhancements under simulated diversion conditions. It was ascertained from three field sites of varying tree density/health in Lake Maurepas swamps that nutrient augmentation (similar to N and P loading rates expected from 8000cfs …
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The Contextual Roles of Isocitrate Dehydrogenase-1 and Isocitrate Dehydrogenase-2 in Electron Transport Chain Complex III Deficiency
… did not suppress cell growth or survival under nutrient-replete conditions. However, we identified differential effects on reductive metabolism and on cell survival under nutrient deprivation. Specifically, we find that IDH1 is primarily responsible for reductive glutamine metabolism in these …
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