Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Nutrient Transporters"”.
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Expression of Digestive Enzymes and Nutrient Transporters in the Intestine of Eimeria-challenged Chickens
… changes in expression of digestive enzymes and nutrient transporters in the intestine. The objective of this thesis was to examine the expression of digestive enzymes: APN and SI, peptide and amino acid transporters: Pept1, ASCT1, bo,+AT/rBAT, B0AT, CAT1/2, EAAT3, LAT1 and y+LAT1/2, sugar …
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Gene Expression of Nutrient Transporters and Digestive Enzymes in the Yolk Sac Membrane and Small Intestine of the Developing Embryonic Chick
Chick embryos derive nutrients from the yolk during incubation and transition to intestinal absorption posthatch. Nutrient uptake is mediated by digestive enzymes and membrane bound transporter proteins. The objective of this study was to determine expression profiles of nutrient transporters and …
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Temporal and Tissue Specific Changes in Expression of Nutrient Transporters and Host Defense Peptides in Young Broilers during Salmonella and Campylobacter infections
… to evaluate the influence on mRNA abundance of nutrient transporters and host defense peptides (HDPs) during a Salmonella or a Campylobacter challenge in young commercial broilers. Comparisons were made between non-challenged and challenged (106, 107, or 108 colony forming units of Salmonella or …
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Short-Chain Fatty Acids and Functional Adaptations in the Neonatal Intestine
… jejunum), but not ileum. Transport of certain nutrients (glucose and arginine) was enhanced in the colon by SCFA and Bu. Whenever effects were observed with the SCFA group, similar effects were also observed with Bu group(s), indicating that Bu is the main SCFA responsible for these changes. …
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Nutrient Transporter targeted Delivery of HIV Protease Inhibitors
… novel Saq vitamin prodrugs targeting influx nutrient transporters and circumvent the P-gp mediated efflux as well as CYP3A4 mediated metabolism thus improving the absorption and bioavailability of Saq. First, two vitamin transport systems including sodium-dependent multivitamin transporter …
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Placental (Mal)Adaptation in Maternal Obesity: Immune-Mediated Regulation of Placental Nutrient Partitioning and Fetal Growth
… obesity, and inflammation may disrupt placental nutrient partitioning potentially leading to fetal growth restriction. To address this, both murine and in vitro models were employed. Mice were fed a high-fat high-sugar (HFHS) diet 9-weeks prior to and throughout pregnancy to create a diet-induced …
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Developmental Gene Expression in the Small Intestine of Chickens from Lines Divergently Selected for High or Low Juvenile Body Weight
Nutrient transporters in the small intestine are responsible for dietary nutrient assimilation and therefore the expression of these transporters can influence the overall nutrient status as well as the growth and development of the animal. This thesis examined correlated responses to selection in …
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Small Intestinal Transporters in Two Species of Galliformes: Male and Female Turkey (Meleagris gallopavo) and Chicken (Gallus gallus)
… was expressed greater in males. Basolateral transporters were expressed more during early development; while there was more expression of brush border transporters EAAT3, GLUT5 and SGLT1 later in development. In chickens, there are alternatively spliced exons of the PepT2 gene that encode …
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The exo-proteomic framework for nitrogen acquisition from proteinaceous organic matter in the model marine heterotroph Ruegeria pomeroyi DSS-3
… encode a wide variety of hydrolytic enzymes and nutrient transporters, which provide them with the ability to sustain nutrient stresses and inhabit protein-rich niche habitats such as sinking or suspended particles. Despite their important contribution to the oceanic nitrogen cycle, and marine …
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Insights into the regulation of mTOR signaling and the consequences of pharmacological inhibition
… signals initiate a cascade of events that send nutrient transporters to the membrane, suppress apoptosis, boost protein synthesis, and adjust metabolic processes to fuel the cell's energy demands. Increases in cell growth are often coordinated with cell division, though the two programs can be …
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Cellular Events During Coccidial Infection in Chickens
… changes in expression of digestive enzymes and nutrient transporters in the intestine. This can also lead to diminished intracellular pools of nutrients and inhibit pathogen replication. In this dissertation, further analysis of cellular events was performed. Expression of host defense peptides …
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Metabolically rewiring pancreatic stromal cells in pancreatic cancer
… which distorts tumour vasculature. This limits nutrient, oxygen and chemotherapy perfusion into pancreatic tumours and promotes oxidative stress. The craftsmen of fibrosis are cancer-associated pancreatic stellate cells (CA-PSCs) who drive disease progression, chemoresistance and metastasis. To …
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EVASION OF EFFLUX AND ENHANCING BIOAVAILABILITY OF AMPRENAVIR BY PRODRUG DERIVATIZATION
… Amprenavir (APV) by prodrug strategies targeting nutrient transporters to bypass P-glycoprotein (P-gp) mediated efflux. APV has low bioavailability and negligible brain absorption which is attributed by low aqueous solubility, efflux mediated by multidrug resistance proteins, extensive metabolism …
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Ocular pharmacokinetics and efficacy of various amino acid and dipeptide prodrugs of ganciclovir
… and diester prodrugs were designed to target the nutrient transporters peptide transporter (hPEPT1) and sodium dependent neutral and cationic transporter (B [super 0,+]), respectively. The overall objectives of this study are to evaluate cytotoxicity and uptake of prodrugs in rabbit corneal …
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Short-Chain Fatty Acids and Glucagon -Like Peptide-2 Enhance Intestinal Development and Adaptation
… transport and the protein expression of nutrient transporters. The provision of GLP-2 and supplementation of TPN with butyrate, which augments endogenous levels of GLP-2, may benefit patients with intestinal dysfunctions by maximizing their intestinal absorptive capacity, thereby enabling …
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Effects of Incubation Temperature and Transportation Stress on Yolk Utilization, Small Intestine Development, and Post-Hatch Performance of High-Yield Broiler Chicks
… temperature (IT) on post-hatch relative nutrient transporter gene expression, integrity of the intestinal epithelium, organ development, and performance in Ross 308 broiler chickens. Nine hundred fertile eggs were incubated at different egg-shell temperatures during development. Body …
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Functional Genomic Examinations Of Interactions Between Common Members Of The Human Gut Microbiota
… polysaccharide degradation genes and upregulates nutrient transporters, likely allowing it to access sugars released by <italic>B. thetaiotaomicron's</italic> glycoside hydrolases. These models of the human gut microbiota illustrate niche specialization and functional redundancy within the …
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Distribution and Relative Abundance of Nutrient Transporter mRNA in the Gastrointestinal Tract of Black Bears
… of the physiological processes associated with nutrient assimilation by black bears. Distribution and relative abundance of mRNA of a peptide transporter (PepT1), a glucose transporter (SGLT1), two AA transporters (NBAT, bo,+AT), and a digestive enzyme, aminopeptidase N (APN), in the intestinal …
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Glucose-6-Phosphatase in Metabolic Disease and Cancer
… by germline mutations in metabolic enzymes and nutrient transporters, provide an opportunity to observe how discrete metabolic defects cause human disease. Glycogen Storage Disease Type 1a (GSD1a), or von Gierke's disease, is an autosomal recessive IEM caused by defects in Glucose-6-Phosphatase, …
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The role of the Igf2/H19 locus in regulating murine placental endocrine capacity
The placenta is responsible for materno-fetal nutrient transfer and produces an abundance of hormones and signalling factors that adapt maternal metabolism to support fetal growth. In mice, these functions are performed in two distinct placental regions, the transport labyrinth zone (Lz) and the …
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