Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Nutlin-3a"”.
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Preclinical Pharmacology of the MDM2 Antagonist Nutlin-3a
<p>Nutlin-3a is an MDM2-p53 interaction antagonist that is under investigation in preclinical models for a variety of pediatric malignancies, including neuroblastoma, retinoblastoma, leukemia, and rhabdomyosarcoma. In the current research, we conducted preclinical pharmacology studies of nutlin-3a …
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Delineating mechanisms which underlie differential cell fates induced by p53 activation and HDAC inhibition in colorectal cancer
… combined treatment with the MDM2 inhibitor, Nutlin-3A, and the Class I specific HDACi, Entinostat, when compared to Nutlin-3A treatment alone. Indeed, the addition of Entinostat was instead found to decrease the expression of p53 induced anti-apoptotic proteins which most notably included the …
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Translational control mechanisms in the p53 response network
… profiling in MCF7 cells upon Doxorubicin and Nutlin-3a treatments. Among translated genes, we detected the presence of translationally enhanced mRNAs with a virtually absent transcriptional modulation; those genes were enriched for apoptotic functions, suggesting that the apoptotic phenotype …
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p53 Functional Interactions: the Study of a New Crosstalk with Estradiol Pathway in Transcriptional Responses to Chemotherapeutics
… to 5-fuorouracil (another genotoxic drug) and nutlin-3a (a non-genotoxic p53-specific activator), the combined response identified genes that were consistently regulated, although with different kinetics (e.g. INPP5D, CDH26, KRT15), while others (e.g. TLR5, SOX9) were treatment selective. …
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Investigating the Regulation and Function of the NR4A Nuclear Receptors in Cancer
… expression downstream of p53 activation by Nutlin-3a was associated with decreased endogenous NR4A2. Additionally, overexpression of NR4A2 was capable of suppressing the activation of p53 target genes, and was also able to attenuate the sensitivity of cells to the anti-proliferative effect …
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Targeting The Mdm2-P53 Axis For The Treatment of Dedifferentiated Liposarcoma
… to those of the older generation MDM2 inhibitors Nutlin-3a and MI-219. Most importantly, these cell based experiments were replicated <em>in vivo</em> where oral administration of SAR405838 resulted in potent anti-DDLPS effects in a dose-dependent manner (50-200 mg/kg).</p> <p>Finally, to …
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HDAC inhibition results in suppression of FOXM1 and genes associated with poor prognosis prostate cancer through p53 dependent and independent mechanisms
… of both the p53 activating MDM2 inhibitor, Nutlin-3A and radiotherapy, resulting in a synergistic induction of cell death dependent on WT p53. Further exploration into the mechanism of cell death demonstrated induction of pro-apoptotic BIM and PUMA alongside repression of anti-apoptotic …